Results 141 to 150 of about 7,087,225 (342)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

A Smoothed P-Value Test When There is a Nuisance Parameter under the Alternative

open access: yes, 2018
We present a new test when there is a nuisance parameter under the alternative hypothesis. The test exploits the p-value occupation time [PVOT], the measure of the subset of a nuisance parameter on which a p-value test rejects the null hypothesis.
Hill, Jonathan B.
core  

Posterior Predictive $p$-Values

open access: yesThe Annals of Statistics, 1994
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +3 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

The earth's rotation-dominated seismicity preceding the 2023 MW7.8 Gaziantep, Türkiye, earthquake

open access: yesGeodesy and Geodynamics
For earthquakes (M ≥ 4.0) occurring along and around the East Anatolian fault zone and the Dead Sea fault zone within ten years immediately before the MW7.8 Gaziantep earthquake, Türkiye, of February 6, 2023, we explored the correlation between ...
Yane Li, Xuezhong Chen, Lijuan Chen
doaj   +1 more source

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