Results 171 to 180 of about 7,087,225 (342)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Closed 𝓐-pQuasiconvexity and Variational Problems with Extended Real-Valued Integrands [PDF]

, 2017
Adam Prosinski
openalex   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

E-value: a superior alternative to P-value and its adjustments in DNA methylation studies. [PDF]

Brief Bioinform, 2023
Yang Y, Liu H, Liu Y, Zhou L, Zheng X, Yue R, Mattson DL, Kidambi S, Liang M, Liu P, Pan X.   +10 more
europepmc   +1 more source

<p>Lessons From Star Trek: Examining the Social Values Embedded in Technological Programs</p>

, 2000
John W. Hansen
openalex   +1 more source

POSITIVE SOLUTIONS FOR A <i>P</i>-LAPLACIAN TYPE SYSTEM OF IMPULSIVE FRACTIONAL BOUNDARY VALUE PROBLEM<inline-formula><tex-math id="M1">$ ^* $</tex-math></inline-formula>

, 2020
Dongping Li, Fangqi Chen, Yukun An
openalex   +1 more source

The Best Constant of $L^p$ Sobolev Inequality Including $j$-th Derivative Corresponding to Periodic and Neumann Boundary Value Problem for $(-1)^M(d/dx)^{2M}$ [PDF]

, 2014
Kohtaro Watanabe, Hiroyuki Yamagishi
openalex   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Significance of hypothesis and P value. [PDF]

J Indian Prosthodont Soc, 2023
Vaidyanathan AK.
europepmc   +1 more source