Results 221 to 230 of about 23,411 (243)

Oral infection with P. gingivalis exacerbates autoimmune encephalomyelitis

Journal of Periodontology, 2018
AbstractBackgroundOral infection of mice with P. gingivalis induces periodontal inflammation and attachment loss. The aim of the present study was to investigate whether infection of mice with P. gingivalis, exacerbates the clinical course of experimental autoimmune encephalomyelitis (EAE)—a mouse model of multiple sclerosis (MS).MethodsInduction of ...
David, Polak, Aviv, Shmueli, Talma, Brenner, Lior, Shapira   +3 more
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Effects of Tobacco and P. gingivalis on Gingival Fibroblasts

Journal of Dental Research, 2010
Cigarette smoke condensate (CSC) is the particulate matter of cigarette smoke. Porphyromonas gingivalis ( P. gingivalis) is an opportunistic pathogen involved in periodontitis. It was hypothesized that the combination of CSC and P. gingivalis would increase the collagen-degrading ability of human gingival fibroblasts (HGFs).
W, Zhang, F, Song, L J, Windsor
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High Antibody Levels to P. gingivalis in Cardiovascular Disease

Journal of Dental Research, 2010
Recent evidence suggests that strain variation in the serum IgG response to Porphyromonas gingivalis occurs in periodontal disease and cardiovascular disease (CVD). This study aimed to test the hypothesis that different P. gingivalis strains would elicit different levels of IgG, depending on a patient’s cardiovascular (CV) and periodontal health.
Bohnstedt, S., Cullinan, M. P., Ford, P. J., Palmer, J. E., Leishman, S. J., Westerman, B., Marshall, R. I., West, M. J., Seymour, G. J.   +8 more
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Dendritic-NK Cell Interactions in P. gingivalis-specific Responses

Journal of Dental Research, 2005
Patients with localized aggressive periodontitis have type-1 cytokines in gingival crevicular fluid and high titers of IFN-γ-dependent IgG2 reactive with P. gingivalis in gingival crevicular fluid and serum. Localized aggressive periodontitis monocytes spontaneously differentiate into dendritic cells that can stimulate IFN-γ production by NK cells ...
T, Kikuchi, D L, Willis, M, Liu, D B, Purkall, S, Sukumar, S E, Barbour, H A, Schenkein, J G, Tew   +7 more
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Interferon-gamma Deficiency Attenuates Local P. gingivalis-induced Inflammation

Journal of Dental Research, 2002
Infection with the periodontal pathogen Porphyromonas gingivalis causes a strong local inflammatory reaction. Using IFNγ-deficient mice, we tested the hypothesis that the absence of IFNγ would result in a reduction of the local pro-inflammatory response to P. gingivalis.
Y, Houri-Haddad, W A, Soskolne, E, Shai, A, Palmon, L, Shapira   +4 more
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Cytokine profiles of Porphyromonas gingivalis‐reactive T lymphocyte lines and clones derived from P. gingivalis‐infected subjects

Oral Diseases, 1995
Porphyromonos gingivolis is generally recognized as a major periodontopathogen such that a study of T cell responses to this organism may help to elucidate immune regulation in periodontal disease.OBJECTIVE The aim of this study was to examine interleukin (IL)‐4, interferon (IFN)‐gamma and IL‐10 production by p‐gingivolis‐responsive T cell lines and ...
Gemmell E., Kjeldsen M., Yamazaki K., Nakajima, Aldred M.J., Seymour   +5 more
openaire   +3 more sources

IL-10 Gene Transfer Attenuates P. gingivalis-induced Inflammation

Journal of Dental Research, 2007
IL-10 is an anti-inflammatory cytokine secreted by stimulated Th2 lymphocytes that can down-regulate inflammatory responses to bacterial challenge. We hypothesized that local delivery of IL-10 using gene-transfer will down-regulate inflammatory responses. We examined the effect of IL-10 plasmid injection on the local cytokine response. Two weeks after
Y, Houri-Haddad, W A, Soskolne, A, Halabi, L, Shapira   +3 more
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P. gingivalis antigenic composition

2008
The present invention provides an antigenic composition, the composition comprising at least one recombinant protein. The recombinant protein comprises at least one epitope. The epitope is reactive with an antibody which is reactive with a polypeptide having the sequence set out in SEQ ID NO. 3 or SEQ ID NO.5.
CSL LTD, UNIV MELBOURNE
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Role of Porphyromonas gingivalis 40-kDa outer membrane protein in the aggregation of P. gingivalis vesicles and Actinomyces viscosus

Archives of Oral Biology, 1992
Porphyromonas gingivalis, an important pathogen in periodontitis, produces extracellular vesicles that aggregate with Actinomyces viscosus cells. A 40-kDa outer membrane protein (OMP)-coding gene from P. gingivalis was cloned and the protein was found to be localized in these vesicles.
K, Hiratsuka, Y, Abiko, M, Hayakawa, T, Ito, H, Sasahara, H, Takiguchi   +5 more
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Distinctive pathways characterize A. actinomycetemcomitans and P. gingivalis.

Molecular biology reports, 2016
The study aimed to compare the molecular mechanism of Porphuromonas gingivalis (P. gingivalis) and Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans). With microarray dataset (GSE9723) from Gene Expression Omnibus, differentially expressed genes (DEGs) were identified comparing normal cell samples with A.
Jing, Lv, Yi-Xin, Zhu, Ying-Qun, Liu, Xin, Xue   +3 more
openaire   +1 more source