Results 71 to 80 of about 27,075 (176)

Structural Basis for Nucleobase Activation by the Adenine DNA Glycosylase MutY

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
DNA glycosylase MutY engages its adenine nucleobase substrate in a syn orientation with a catalytic Glu. X‐ray crystal structures of MutY with Glu replaced suggest that a disengaged “on hold” state with anti nucleobase orientation may explain how MutY avoids catastrophic activity at inappropriate adenines.
L. Peyton Russelburg, Merve Demir, Karina Cedeno, Sheila S. David, Martin P. Horvath   +4 more
wiley   +1 more source

Development of PCR–RFLP assay for the discrimination of Plasmodium species and variants of P. vivax (VK210, VK247 and P. vivax-like) in Anopheles mosquitoes

Acta Tropica, 2011
The identification of Plasmodium species in Anopheles mosquitoes is an integral component of malaria control programs. We developed a new assay to identify Plasmodium falciparum, Plasmodium malariae, and Plasmodium vivax variants. Specific primers were designed to hybridize to CS gene-specific regions.
Cassiano, Gustavo Capatti, Storti-Melo, Luciane Moreno, Póvoa, Marinete Marins, Galardo, Allan Kardec Ribeiro, Rossit, Andréa Regina Baptista, Machado, Ricardo Luiz Dantas   +5 more
openaire   +2 more sources

Acquired antibody responses against Plasmodium vivax infection vary with host genotype for duffy antigen receptor for chemokines (DARC).

PLoS ONE, 2010
BackgroundPolymorphism of the Duffy Antigen Receptor for Chemokines (DARC) is associated with susceptibility to and the severity of Plasmodium vivax malaria in humans. P. vivax uses DARC to invade erythrocytes. Individuals lacking DARC are 'resistant' to
Amanda Maestre, Carlos Muskus, Victoria Duque, Olga Agudelo, Pu Liu, Akihide Takagi, Francis B Ntumngia, John H Adams, Kim Lee Sim, Stephen L Hoffman, Giampietro Corradin, Ivan D Velez, Ruobing Wang   +12 more
doaj   +1 more source

Profiling vivax malaria incidence, residual transmission, and risk factors using reactive case detection in low transmission settings of Ethiopia

Malaria Journal
Background Identification of local Plasmodium vivax transmission foci and its hidden reservoirs are crucial to eliminating residual vivax malaria transmission. This study assessed whether reactive case detection (RCD) could better identify P. vivax cases
Ashenafi Abossie, Hallelujah Getachew, Assalif Demissew, Kassahun Habtamu, Arega Tsegaye, Daibin Zhong, Xiaoming Wang, Teshome Degefa, Ming-Chieh Lee, Guofa Zhou, Christopher L. King, James W. Kazura, Delenasaw Yewhalaw, Guiyun Yan   +13 more
doaj   +1 more source

Plasmodium vivax invasion of human erythrocytes inhibited by antibodies directed against the Duffy binding protein.

PLoS Medicine, 2007
BackgroundPlasmodium vivax invasion requires interaction between the human Duffy antigen on the surface of erythrocytes and the P. vivax Duffy binding protein (PvDBP) expressed by the parasite. Given that Duffy-negative individuals are resistant and that
Brian T Grimberg, Rachanee Udomsangpetch, Jia Xainli, Amy McHenry, Tasanee Panichakul, Jetsumon Sattabongkot, Liwang Cui, Moses Bockarie, Chetan Chitnis, John Adams, Peter A Zimmerman, Christopher L King   +11 more
doaj   +1 more source

Tracing the origins of Plasmodium vivax resurgence after malaria elimination on Aneityum Island in Vanuatu

Communications Medicine
Background Five years after successful malaria elimination, Aneityum Island in Vanuatu experienced an outbreak of Plasmodium vivax of unknown origin in 2002. Epidemiological investigations revealed several potential sources of P. vivax.
Sho Sekine, Chim W. Chan, Morris Kalkoa, Sam Yamar, Harry Iata, George Taleo, Achyut KC, Wataru Kagaya, Yasutoshi Kido, Akira Kaneko   +9 more
doaj   +1 more source

Parasite biomass-related inflammation, endothelial activation, microvascular dysfunction and disease severity in vivax malaria.

PLoS Pathogens, 2015
Plasmodium vivax can cause severe malaria, however its pathogenesis is poorly understood. In contrast to P. falciparum, circulating vivax parasitemia is low, with minimal apparent sequestration in endothelium-lined microvasculature, and pathogenesis ...
Bridget E Barber, Timothy William, Matthew J Grigg, Uma Parameswaran, Kim A Piera, Ric N Price, Tsin W Yeo, Nicholas M Anstey   +7 more
doaj   +1 more source

Understanding the population genetics of Plasmodium vivax is essential for malaria control and elimination

Malaria Journal, 2012
Traditionally, infection with Plasmodium vivax was thought to be benign and self-limiting, however, recent evidence has demonstrated that infection with P. vivax can also result in severe illness and death. Research into P.
Arnott Alicia, Barry Alyssa E, Reeder John C   +2 more
doaj   +1 more source

Epidemiology of Plasmodium vivax in Duffy negatives and Duffy positives from community and health centre collections in Ethiopia

Malaria Journal
Background Malaria remains a significant cause of morbidity and mortality in Ethiopia with an estimated 3.8 million cases in 2021 and 61% of the population living in areas at risk of malaria transmission.
Lauren Bradley, Delenasaw Yewhalaw, Elizabeth Hemming-Schroeder, Brook Jeang, Ming-Chieh Lee, Endalew Zemene, Teshome Degefa, Eugenia Lo, Christopher King, James Kazura, Guiyun Yan   +10 more
doaj   +1 more source

Suppression of erythroid development in vitro by Plasmodium vivax

Malaria Journal, 2012
Background Severe anaemia due to dyserythropoiesis has been documented in patients infected with Plasmodium vivax, however the mechanism responsible for anaemia in vivax malaria is poorly understood. In order to better understand the role of P.
Panichakul Tasanee, Payuhakrit Witchuda, Panburana Panyu, Wongborisuth Chokdee, Hongeng Suradej, Udomsangpetch Rachanee   +5 more
doaj   +1 more source