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Renin inhibitors containing new P1-P1' dipeptide mimetics with heterocycles in P1'

Journal of Medicinal Chemistry, 1992
A series of renin inhibitors containing new P1-P1' dipeptide mimetics are presented. The P1-P1' mimetics were obtained from (4S,5S)-3-(tert-butoxycarbonyl)-4-(cyclohexylmethyl)-5-[(omega- mesyloxy)alkyl]-2,2-dimethyloxazolidines 5b, 9, and 11b by nucleophilic substitution of the mesylate groups with the sodium salts of mercapto- and hydroxyheterocycles.
P, Raddatz   +5 more
openaire   +2 more sources

Synthesis of P1 ban protein in minicells infected by P1 mutants

Molecular and General Genetics MGG, 1980
Phage P1 encodes a dnaB analog (ban) protein. Synthesis of ban protein has been studied in minicells infected by P1 mutants and has been identified as a polypeptide of 56,000 molecular weight by immunoprecipitation using antibody directed against E. coli dnaB protein.
J N, Reeve, E, Lanka, H, Schuster
openaire   +2 more sources

One-pot carbanionic synthesis of P1,P2-diglycosyl, P1,P1,P2-triglycosyl, and P1,P1,P2,P2-tetraribosyl methylenediphosphonates.

The Journal of organic chemistry, 2007
Novel lithiated carbanions derived from ethyl glycosyl- and diglycosyl methylphosphonates were used in a direct and convenient synthesis of P1,P2-diglycosyl, P1,P1,P2-triglycosyl, and P1,P1,P2,P2-tetraribosyl methylenediphosphonates involving a one-pot methylidenediphosphonylation of sugars.
Claude, Grison   +3 more
openaire   +1 more source

Good reduction of certain covers P1 → P1

Israel Journal of Mathematics, 2001
We investigate the existence of distinct polynomialsF, G having roots of prescribed multiplicities and deg(F −G) as small as predicted by Mason’sabc theorem. The case of characteristic zero has been treated completely in a previous paper, but those methods do not apply in positive characteristic.
openaire   +1 more source

The simplest minimal free resolutions in P1×P1

2021
We study the minimal bigraded free resolution of an ideal with three generators of the same bidegree, contained in the bihomogeneous maximal ideal 〈s, t〉∩〈u, v〉 of the bigraded ring K[s,t;u,v]. Our analysis involves tools from algebraic geometry (Segre-Veronese varieties), classical commutative algebra (Buchsbaum-Eisenbud criteria for exactness ...
Botbol, Nicolas Santiago   +2 more
openaire   +1 more source

The explanation of the ?P1? in an electrocochleogram

Archives of Oto-Rhino-Laryngology, 1978
Repeatedly a solitary positive P1 peak was recorded from the auditory nerve in animal experiments during hypoxy. An explanation is given for this p1 peak, which is also found with people having pathological electrocochleograms. This P1 is formed in the auditory nerve by an approaching wave, a positive shift of polarity as introduction to the negatively
openaire   +2 more sources

Propositional Algebra P1

2015
In this semi-expository paper we investigate the propositional algebra P1, some properties and its relationship with Curry algebra P1. We show as in the classical case that both structures are equivalent in the sense of Bourbaki. Some results on the extension to the propositional algebras Pn (1 ≤ n ≤ ω) are also made.
Jair Minoro Abe   +3 more
openaire   +1 more source

Design of Renin Inhibitors Containing Conformationally Restricted Mimetics of the P1-P1′ and P1 through P2′ Sites

1991
The clinical efficacy of converting enzyme inhibitors1 for reducing blood pressure in a large percentage of hypertensive patients has aroused considerable interest in developing agents that interrupt the renin-angiotensin system at other points, for example by blockade of the angiotensin II receptor2 or by inhibition of the aspartic proteinase, renin ...
Peter D. Williams   +18 more
openaire   +2 more sources

P1

Journal of Nutrition Education and Behavior, 2007
Candece D. Goshorn   +3 more
  +4 more sources

P1

Surgery for Obesity and Related Diseases, 2006
Katherine L. Applegate   +2 more
openaire   +2 more sources

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