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Characterization of the Focal Adhesion Kinase/p130Cas pathway in Ocular Cell Adhesions [PDF]
イモト, ヨシコ, 井本, 昌子
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p130Cas: a versatile scaffold in signaling networks [PDF]
Trends in Cell Biology, 2006 The Cas family of multiadaptor and scaffold molecules has an essential role in intracellular signaling events. Although these proteins do not have enzymatic or transcriptional activity, they spatially and temporally control signaling events through their ability to undergo changes in phosphorylation and to associate with effectors proteins in ...
DEFILIPPI, Paola +2 more
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The interaction of CFLAR with p130Cas promotes cell migration
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2023CASP8 and FADD Like Apoptosis Regulator (CFLAR) is a key anti-apoptotic regulator for resistance to apoptosis mediated by Fas and TRAIL. In addition to its anti-apoptotic function, CFLAR is also an important mediator of tumor growth. High level of CFLAR expression correlates with a more aggressive tumor.
Hao, Li +4 more
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p130Cas-dependent actin remodelling regulates myogenic differentiation
Biochemical Journal, 2012Actin dynamics are implicated in various cellular processes, not only through the regulation of cytoskeletal organization, but also via the control of gene expression. In the present study we show that the Src family kinase substrate p130Cas (Cas is Crk-associated substrate) influences actin remodelling and concomitant muscle-specific gene expression ...
Kawauchi, K. +7 more
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Changes of podocyte p130Cas in diabetic conditions
Journal of Nephrology, 2013Proteinuria results from increased glomerular permeability and is associated with retraction and effacement of the highly specialized interdigitating podocyte foot processes. In podocytes (glomerular epithelial cells [GECs]), p130Cas localizes diffusely to the cytoplasm and connects focal adhesion proteins and kinases to the glomerular basement ...
Tae-Sun, Ha +3 more
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The unique function of p130Cas in regulating the bone metabolism
Pharmacology & Therapeutics, 2022p130 Crk-associated substrate (Cas) functions as an adapter protein and plays important roles in certain cell functions, such as cell proliferation, spreading, migration, and invasion. Furthermore, it has recently been reported to have a new function as a mechanosensor.
Eijiro, Jimi +2 more
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Organization of functional domains in the docking protein p130Cas
Biochemical and Biophysical Research Communications, 2004The docking protein p130Cas becomes phosphorylated upon cell adhesion to extracellular matrix proteins, and is thought to play an essential role in cell transformation. Cas transmits signals through interactions with the Src-homology 3 (SH3) and Src-homology 2 domains of FAK or v-Crk signaling molecules, or with 14-3-3 protein, as well as phosphatases ...
Fariborz, Nasertorabi +6 more
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p130Cas: A key signalling node in health and disease
Cellular Signalling, 2013p130Cas/breast cancer anti-oestrogen resistance 1 (BCAR1) is a member of the Cas (Crk-associated substrate) family of adaptor proteins, which have emerged as key signalling nodes capable of interactions with multiple proteins, with important regulatory roles in normal and pathological cell function.
Angela, Barrett +4 more
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Phosphorylation-dependent cleavage of p130cas in apoptotic rat-1 cells
Biochemical and Biophysical Research Communications, 2003We previously demonstrated caspase-mediated cleavage of p130cas during apoptosis and identified two caspase-3 cleavage sites [1]. In this study, we investigated the phosphorylation-dependent cleavage of p130cas in apoptotic Rat-1 fibroblast cells.
Do, Hoon Kim +4 more
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