Results 11 to 20 of about 75,888 (256)
IKKβ specifically binds to P16 and phosphorylates Ser8 of P16 [PDF]
Biochemical and Biophysical Research Communications, 2010 In spite of its central roles in cell cycle progression, senescence, and aging, knowledge about the posttranslational regulation of P16 (also known as INK4A and MTS1) remains limited. While it has been reported that P16 could be phosphorylated at Ser7, Ser8, Ser140, and Ser152, the corresponding kinases have not been identified yet. Here we report that
Yi, Guo +3 more
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A study on the correlation between HPV DNA and IHC P16 expression in cervical lesions [PDF]
Zhongguo aizheng zazhiBackground and purpose: Human papilloma virus (HPV) infection status is crucial for diagnosing cervical precancerous lesions and classifying cervical cancer.
WANG Haochen, JIA Liqing, YANG Yu, WANG Qian, YU Chengli, TIAN Tian, BI Rui, TU Xiaoyu, BAI Qianming, ZHU Xiaoli, ZHOU Xiaoyan, REN Min
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Respiratory Research, 2022 Background Idiopathic pulmonary fibrosis (IPF) is associated with increased expression of cyclin-dependent kinase inhibitors such as p16 and p21, and subsequent induction of cell cycle arrest, cellular senescence, and pro-fibrotic gene expression.
Jonathan Keow +5 more
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p16 Stimulates CDC42-dependent migration of hepatocellular carcinoma cells. [PDF]
PLoS ONE, 2013 Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths worldwide. Tumor dissemination to the extra-hepatic region of the portal vein, lymph nodes, lungs or bones contributes to the high mortality seen in HCC; yet, the molecular ...
Ya-Wen Chen +6 more
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Prognostic significance of p16 immunohistochemical expression in urothelial carcinoma
Surgical and Experimental Pathology, 2019 Background p16 is the protein product of most commonly involved gene in bladder carcinogenesis. Therefore, we performed an immunohistochemical study to evaluate association of p16 overexpression with prognostic parameters in bladder cancer.
Atif Ali Hashmi +5 more
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BMC Cancer, 2021 Background Lower prevalence HPV infection has been previously reported in Thai population when compared with Western countries. p16 expression indicates HPV-associated oropharyngeal squamous cell carcinoma (OPSCC), but not non-OPSCC.
Lalida Arsa +9 more
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The Senescence Marker p16Ink4a—A Player of Liver Endothelial Cells Physiology
Biology and Life Sciences Forum, 2023 P16INK4A is a tumor suppressor and cell cycle regulator that has been linked to aging and senescence. In development, a potential role of p21 and of p19ARF has been postulated, but little is known about p16. Our previous results revealed a highly dynamic
Hasan Safwan-Zaiter +2 more
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The International Journal of Biological Markers, 2016 Background p16 has been indicated as a suitable surrogate biomarker of HPV infection. The prognosis of p16-positive oropharynx tumors (OTs) of squamous cell carcinoma (SCC) histology is better than that of p16-negative tumors.
Marco Carlo Merlano +7 more
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Chimeras of p14ARF and p16: functional hybrids with the ability to arrest growth. [PDF]
PLoS ONE, 2014 The INK4A locus codes for two independent tumor suppressors, p14ARF and p16/CDKN2A, and is frequently mutated in many cancers. Here we report a novel deletion/substitution from CC to T in the shared exon 2 of p14ARF/p16 in a melanoma cell line.
Richard T Williams +6 more
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P16 methylation increases the sensitivity of cancer cells to the CDK4/6 inhibitor palbociclib.
PLoS ONE, 2019 The P16 (CDKN2Aink4a) gene is an endogenous CDK4/6 inhibitor. Palbociclib (PD0332991) is an anti-CDK4/6 chemical for cancer treatment. P16 is most frequently inactivated by copy number deletion and DNA methylation in cancers. It is well known that cancer
Paiyun Li +4 more
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