Results 11 to 20 of about 89,060 (300)
p16(INK4a) translation suppressed by miR-24. [PDF]
PLoS ONE, 2008 Expression of the tumor suppressor p16(INK4a) increases during aging and replicative senescence.Here, we report that the microRNA miR-24 suppresses p16 expression in human diploid fibroblasts and cervical carcinoma cells.
Ashish Lal +13 more
doaj +2 more sources
Hypermethylation of the p16 Gene and Lack of p16 Expression in Hepatoblastoma [PDF]
Modern Pathology, 2003 Hepatoblastoma is the most frequent pediatric liver tumor that develops mostly in young children. Abnormal regulation of cell cycle regulatory genes including p16 has been described, displaying no p16 mRNA and p16 protein in hepatoblastomas. The inactivation of p16, leading to the disruption of cell cycle control is involved in many types of human ...
Ja-June Jang, Eunsil Yu, Kim Jung Sun
exaly +3 more sources
Clinical characteristics and treatment outcome in p16 negative anal cancer
Acta OncologicaBackground: Anal squamous cell carcinoma (ASCC) is linked to human papillomavirus infection with p16 being positive in about 85% of cases. Overall survival (OS) of ASCC is 60%–80%. Prognosis in p16 negative (p16-) ASCC is worse with an OS of 30%–60%.
Catherine Burgos +4 more
doaj +2 more sources
p16(INK4A) expression in invasive laryngeal cancer
Papillomavirus Research, 2016 We examined p16 expression in tumors from a population-based sample of laryngeal cancer cases diagnosed in the U.S. Samples had been previously genotyped for HPV DNA.Overall, p16 expression was observed in laryngeal tissue from 8 of 101 (7.9%) cases. p16
Brenda Y. Hernandez +12 more
doaj +2 more sources
Journal of Clinical Pathology, 2018 Thep16gene belongs toINK4family of genes and is made up of four members: p16INK4A, p15INK4B, p18INK4Cand p19INK4D, all of which share biological properties, namely, inhibition of cell growth and tumour suppression. Afterp53,p16is the second most common tumour suppressor gene. It has been regarded as the familial melanoma gene.
Stefano Serra, Runjan Chetty
openaire +2 more sources
Treatment failure patterns are similar between p16− and p16+ oropharyngeal squamous cell carcinomas
Laryngoscope Investigative Otolaryngology, 2022 Background The incidence of p16+ oropharyngeal squamous cell carcinoma (OPSCC) has been increasing. The notion that p16+ OPSCC has a propensity for atypical and disseminating metastasis has gained traction.
Chelsea S. Hamill +13 more
doaj +1 more source
Scientific Reports, 2021 The eighth edition of the TNM classifies oropharyngeal squamous cell carcinomas (OSCCs) depending on p16 status. Some imaging features are reportedly associated more frequently with p16-positive (P16+) OSCC than p16-negative (p16−) OSCC.
Jean-Michel Trinh +3 more
doaj +1 more source
Scientific Reports, 2021 p16 inhibits cyclin-dependent kinases and regulates senescence-mediated arrest as well as p21. Nuclear p16 promotes G1 cell cycle arrest and cellular senescence.
Sayo Ueda +8 more
doaj +1 more source
Role of p16 Immunohistochemistry in Cervical Intraepithelial Neoplasia [PDF]
Journal of Clinical and Diagnostic Research, 2020 Introduction: p16 or p16/INK4a is a Cyclin Dependant Kinase Inhibitor 2 (CDKN2) and is upregulated in HPV-related lesions. Therefore, p16 can be considered an indirect marker for altered HR-HPV and growth cycle transformation.
NICHOLAS JOSEPH DCUNHA +2 more
doaj +1 more source
Clinical impact of p16 positivity in nasopharyngeal carcinoma
Laryngoscope Investigative Otolaryngology, 2022 Purpose The clinical characteristics and prognosis of HPV‐related nasopharyngeal cancer (NPC) remain controversial. The relationship between p16 status and outcome was retrospectively investigated in the NPC patients.
Yuri Shimizu +17 more
doaj +1 more source