Cells exhibiting strong p16INK4a promoter activation in vivo display features of senescence [PDF]
, 2019 The activation of cellular senescence throughout the lifespan promotes tumor suppression, whereas the persistence of senescent cells contributes to aspects of aging.
Diekman, Brian O. +9 more
core +3 more sources
Target-Side Context for Discriminative Models in Statistical Machine Translation [PDF]
, 2016 Discriminative translation models utilizing source context have been shown to help statistical machine translation performance. We propose a novel extension of this work using target context information.
Bojar, Ondřej +3 more
core +2 more sources
Endocervical glandular neoplasia associated with lobular endocervical glandular hyperplasia is HPV-independent and correlates with carbonic anhydrase-IX expression: a Gynaecological Oncology Group Study. [PDF]
, 2013 BackgroundLobular endocervical glandular hyperplasia (LEGH) is a rare lesion of the uterine cervix. It has been proposed that LEGH may represent a precursor lesion to a group of mucinous adenocarcinoma with gastric phenotype (GA) that is independent of ...
Carter, R +9 more
core +1 more source
Performance of p16INK4a ELISA as a primary cervical cancer screening test among a large cohort of HIV-infected women in western Kenya: a 2-year cross-sectional study. [PDF]
, 2016 ObjectiveA biomarker with increased specificity for cervical dysplasia compared with human papillomavirus (HPV) testing would be an attractive option for cervical cancer screening among HIV-infected women in resource-limited settings. p16(INK4a) has been
Huchko, Megan J +5 more
core +1 more source
Cyclin D1 and p16 expression in recurrent nasopharyngeal carcinoma [PDF]
, 2006 Background Cyclin D1 and p16 are involved in the regulation of G1 checkpoint and may play an important role in the tumorigenesis of nasopharyngeal carcinoma (NPC).
Berry, Gerald J +3 more
core +3 more sources
Respiratory Research, 2022 Background Idiopathic pulmonary fibrosis (IPF) is associated with increased expression of cyclin-dependent kinase inhibitors such as p16 and p21, and subsequent induction of cell cycle arrest, cellular senescence, and pro-fibrotic gene expression.
Jonathan Keow +5 more
doaj +1 more source
Axonal growth arrests after an increased accumulation of Schwann cells expressing senescence markers and stromal cells in acellular nerve allografts [PDF]
, 2016 Acellular nerve allografts (ANAs) and other nerve constructs do not reliably facilitate axonal regeneration across long defects (>3 cm). Causes for this deficiency are poorly understood.
Ee, Xueping +11 more
core +2 more sources
BMC Cancer, 2021 Background Lower prevalence HPV infection has been previously reported in Thai population when compared with Western countries. p16 expression indicates HPV-associated oropharyngeal squamous cell carcinoma (OPSCC), but not non-OPSCC.
Lalida Arsa +9 more
doaj +1 more source
p16 Stimulates CDC42-dependent migration of hepatocellular carcinoma cells. [PDF]
PLoS ONE, 2013 Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths worldwide. Tumor dissemination to the extra-hepatic region of the portal vein, lymph nodes, lungs or bones contributes to the high mortality seen in HCC; yet, the molecular ...
Ya-Wen Chen +6 more
doaj +1 more source
Chimeras of p14ARF and p16: functional hybrids with the ability to arrest growth. [PDF]
PLoS ONE, 2014 The INK4A locus codes for two independent tumor suppressors, p14ARF and p16/CDKN2A, and is frequently mutated in many cancers. Here we report a novel deletion/substitution from CC to T in the shared exon 2 of p14ARF/p16 in a melanoma cell line.
Richard T Williams +6 more
doaj +1 more source