The Senescence Marker p16Ink4a—A Player of Liver Endothelial Cells Physiology
Biology and Life Sciences Forum, 2023 P16INK4A is a tumor suppressor and cell cycle regulator that has been linked to aging and senescence. In development, a potential role of p21 and of p19ARF has been postulated, but little is known about p16. Our previous results revealed a highly dynamic
Hasan Safwan-Zaiter +2 more
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Taking stock of SLSN and LGRB host galaxy comparison using a complete sample of LGRBs [PDF]
, 2016 Long gamma-ray bursts (LGRBs) and superluminous supernovae (SLSNe) are both explosive transients with very massive progenitor stars. Clues about the nature of the progenitors can be found by investigating environments in which such transients occur ...
Hunt, L. K. +4 more
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Prognostic significance of p16 immunohistochemical expression in urothelial carcinoma
Surgical and Experimental Pathology, 2019 Background p16 is the protein product of most commonly involved gene in bladder carcinogenesis. Therefore, we performed an immunohistochemical study to evaluate association of p16 overexpression with prognostic parameters in bladder cancer.
Atif Ali Hashmi +5 more
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Warty carcinoma of uterine cervix - review of the literature and case report [PDF]
, 2020 Introduction. The Histological Classification of Epithelial Tumors of the Uterine Cervix of the World Health Organization includes inter alia warty carcinoma as a variant of squamous cell carcinoma.
Balalau, Oana Denisa +3 more
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The International Journal of Biological Markers, 2016 Background p16 has been indicated as a suitable surrogate biomarker of HPV infection. The prognosis of p16-positive oropharynx tumors (OTs) of squamous cell carcinoma (SCC) histology is better than that of p16-negative tumors.
Marco Carlo Merlano +7 more
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A study on the correlation between HPV DNA and IHC P16 expression in cervical lesions [PDF]
Zhongguo aizheng zazhiBackground and purpose: Human papilloma virus (HPV) infection status is crucial for diagnosing cervical precancerous lesions and classifying cervical cancer.
WANG Haochen, JIA Liqing, YANG Yu, WANG Qian, YU Chengli, TIAN Tian, BI Rui, TU Xiaoyu, BAI Qianming, ZHU Xiaoli, ZHOU Xiaoyan, REN Min
doaj +1 more source
Aberrant Expression of ID2 protein and its correlation with EBV-LMP1 and P16(INK4A) in Classical Hodgkin Lymphoma in China [PDF]
, 2008 Background The relationships between the expression of ID2, EBV-LMP1 and P16(INK4A) in Chinese classical Hodgkin lymphoma are unknown and need exploring.
Po Zhao, Yali Lu, Lin Liu, Mei Zhong
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p16, pRb, and p53 in Feline Oral Squamous Cell Carcinoma
Veterinary Sciences, 2016 Feline oral squamous cell carcinoma (FOSCC) is a highly aggressive head and neck cancer in cats, but the molecular pathogenesis of this cancer is still uncertain.
Wachiraphan Supsavhad +3 more
doaj +1 more source
Prognostic value of p16, p53, and pcna in sarcoma and an evaluation of immune infiltration
Journal of Orthopaedic Surgery and Research, 2022 Background p16, p53, and proliferating cell nuclear antigen (pcna) genes play significant roles in many chromatin modifications and have been found to be highly expressed in a variety of tumor tissues.
Dechao Cai +6 more
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IKKβ specifically binds to P16 and phosphorylates Ser8 of P16 [PDF]
Biochemical and Biophysical Research Communications, 2010 In spite of its central roles in cell cycle progression, senescence, and aging, knowledge about the posttranslational regulation of P16 (also known as INK4A and MTS1) remains limited. While it has been reported that P16 could be phosphorylated at Ser7, Ser8, Ser140, and Ser152, the corresponding kinases have not been identified yet. Here we report that
Yi, Guo +3 more
openaire +2 more sources