Results 21 to 30 of about 75,888 (256)

p16, pRb, and p53 in Feline Oral Squamous Cell Carcinoma

Veterinary Sciences, 2016
Feline oral squamous cell carcinoma (FOSCC) is a highly aggressive head and neck cancer in cats, but the molecular pathogenesis of this cancer is still uncertain.
Wachiraphan Supsavhad, Wessel P. Dirksen, Blake E. Hildreth, Thomas J. Rosol   +3 more
doaj   +1 more source

Digital Spatial Profiling identifies distinct patterns of immuno-oncology-related gene expression within oropharyngeal tumours in relation to HPV and p16 status

Frontiers in Oncology
BackgroundThe incidence of oropharyngeal cancer (OPC) is increasing, due mainly to a rise in Human Papilloma Virus (HPV)-mediated disease. HPV-mediated OPC has significantly better prognosis compared with HPV-negative OPC, stimulating interest in ...
Jill M. Brooks, Yuanning Zheng, Kelly Hunter, Benjamin E. Willcox, Janet Dunn, Paul Nankivell, Olivier Gevaert, Hisham Mehanna, Hisham Mehanna   +8 more
doaj   +1 more source

Prognostic value of p16, p53, and pcna in sarcoma and an evaluation of immune infiltration

Journal of Orthopaedic Surgery and Research, 2022
Background p16, p53, and proliferating cell nuclear antigen (pcna) genes play significant roles in many chromatin modifications and have been found to be highly expressed in a variety of tumor tissues.
Dechao Cai, Xiao Ma, Huihui Guo, Haotian Zhang, Ashuai Bian, Haoran Yu, Wendan Cheng   +6 more
doaj   +1 more source

Clinical characteristics and treatment outcome in p16 negative anal cancer

Acta Oncologica
Background: Anal squamous cell carcinoma (ASCC) is linked to human papillomavirus infection with p16 being positive in about 85% of cases. Overall survival (OS) of ASCC is 60%–80%. Prognosis in p16 negative (p16-) ASCC is worse with an OS of 30%–60%.
Catherine Burgos, Calin Radu, Sofia Heyman, Nina Cavalli-Björkman, Peter Nygren   +4 more
doaj   +1 more source

The hypermethylation of p16 gene exon 1 and exon 2: potential biomarkers for colorectal cancer and are associated with cancer pathological staging

BMC Cancer, 2018
Background Tumor suppressor gene p16 promoter hypermethylation has been widely studied in colorectal cancer (CRC), yet its clinicopathological significance remains controversial.
Xiaoxia Ye, Mingming Mo, Simin Xu, Qingjin Yang, Minhua Wu, Junjie Zhang, Bin Chen, Jian Li, Yu Zhong, Qionglin Huang, Chun Cai   +10 more
doaj   +1 more source

Coordinated transcription of ANRIL and P16 genes is silenced by P16 DNA methylation [PDF]

Chinese Journal of Cancer Research, 2018
To investigate the relationship between the transcription of ANRIL, P15, P14 and P16 at the same locus and the regulation mechanism of ANRIL.Publicly available database of Cancer Cell Line Encyclopedia (CCLE) was used in bioinformatic analyses. Methylation of CpG islands was detected by denaturing high performance liquid chromatography (DHPLC).
Ying, Gan, Wanru, Ma, Xiuhong, Wang, Juanli, Qiao, Baozhen, Zhang, Chenghua, Cui, Zhaojun, Liu, Dajun, Deng   +7 more
openaire   +2 more sources

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Correlation of p16 Hypermethylation with p16 Protein Loss in Sporadic Gastric Carcinomas [PDF]

Laboratory Investigation, 2000
Hypermethylation of p16 has been detected frequently in a variety of cancer cells and is known to repress the level of p16 transcription. In human gastric carcinoma (GC) cells, p16 protein loss has often been detected, but genetic alterations of p16 are infrequent.
Y H, Shim, G H, Kang, J Y, Ro
openaire   +2 more sources

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Simultaneous Analysis of the p16 Gene and Protein in Canine Lymphoma Cells and Their Correlation with pRb Phosphorylation

Veterinary Sciences, 2022
Cyclin-dependent kinase inhibitor p16 (CDKN2A) primarily functions as a negative regulator of the retinoblastoma protein (pRb) pathway to prevent pRb phosphorylation, thus playing a critical role in cell cycle arrest.
Leni Maylina, Satoshi Kambayashi, Kenji Baba, Masaru Okuda   +3 more
doaj   +1 more source