Results 21 to 30 of about 89,060 (300)
Effect of p16 on glucocorticoid response in a B-cell lymphoblast cell line [PDF]
Korean Journal of Pediatrics, 2010 PurposeIt has been suggested that p16 has a role in glucocorticoid (GC)-related apoptosis in leukemic cells, but the exact mechanisms have yet to be clarified.
Sun-Young Kim +3 more
doaj +1 more source
Indian Journal of Pathology and Microbiology, 2022 Context: p16 is an important tumor suppressor gene and responsible for regulating the cell cycle. Diffuse positivity with p16 in the cervix and head/neck carcinomas can be regarded as a surrogate marker of the presence of high-risk human papillomavirus ...
Elçin Süren +5 more
doaj +1 more source
IKKβ specifically binds to P16 and phosphorylates Ser8 of P16 [PDF]
Biochemical and Biophysical Research Communications, 2010 In spite of its central roles in cell cycle progression, senescence, and aging, knowledge about the posttranslational regulation of P16 (also known as INK4A and MTS1) remains limited. While it has been reported that P16 could be phosphorylated at Ser7, Ser8, Ser140, and Ser152, the corresponding kinases have not been identified yet. Here we report that
Yi, Guo +3 more
openaire +2 more sources
Prediction of progression in pTa and pT1 bladder carcinomas with p53, p16 and pRb. [PDF]
, 2004 Currently available prognostic tools appear unable to adequately predict recurrence and progression in non muscle-invasive bladder carcinomas. We aimed to assess the prognostic value of immunohistochemical evaluation of the cell cycle markers p53, p16 ...
S Jordan +11 more
core +1 more source
DNA Methylation Profiling Revealed Promoter Hypermethylation-induced Silencing of p16, DDAH2 and DUSP1 in Primary Oral Squamous Cell Carcinoma [PDF]
, 2014 Background: Hypermethylation in promoter regions of genes might lead to altered gene functions and result in malignant cellular transformation. Thus, biomarker identification for hypermethylated genes would be very useful for early diagnosis, prognosis ...
Zain, R. B. +8 more
core +1 more source
A study on the correlation between HPV DNA and IHC P16 expression in cervical lesions [PDF]
Zhongguo aizheng zazhiBackground and purpose: Human papilloma virus (HPV) infection status is crucial for diagnosing cervical precancerous lesions and classifying cervical cancer.
WANG Haochen, JIA Liqing, YANG Yu, WANG Qian, YU Chengli, TIAN Tian, BI Rui, TU Xiaoyu, BAI Qianming, ZHU Xiaoli, ZHOU Xiaoyan, REN Min
doaj +3 more sources
The Senescence Marker p16Ink4a—A Player of Liver Endothelial Cells Physiology
Biology and Life Sciences Forum, 2023 P16INK4A is a tumor suppressor and cell cycle regulator that has been linked to aging and senescence. In development, a potential role of p21 and of p19ARF has been postulated, but little is known about p16. Our previous results revealed a highly dynamic
Hasan Safwan-Zaiter +2 more
doaj +1 more source
Respiratory Research, 2022 Background Idiopathic pulmonary fibrosis (IPF) is associated with increased expression of cyclin-dependent kinase inhibitors such as p16 and p21, and subsequent induction of cell cycle arrest, cellular senescence, and pro-fibrotic gene expression.
Jonathan Keow +5 more
doaj +1 more source
BMC Cancer, 2021 Background Lower prevalence HPV infection has been previously reported in Thai population when compared with Western countries. p16 expression indicates HPV-associated oropharyngeal squamous cell carcinoma (OPSCC), but not non-OPSCC.
Lalida Arsa +9 more
doaj +1 more source