Results 261 to 270 of about 89,060 (300)

CDKN2A/p16 in ependymomas

Journal of Neuro-Oncology, 2001
Sixteen cases of ependymoma were studied for CDKN2A/p16 inactivation by immunohistochemistry using a p16 monoclonal antibody, by homozygous deletion (HD) assay and 5'CpG promoter methylation assay (methylation-specific PCR). Three out of 16 cases were p16 immuno-negative: two corresponded to grade II ependymomas and one to grade III.
S, Bortolotto, L, Chiadò-Piat, P, Cavalla, I, Bosone, A, Mauro, D, Schiffer   +5 more
openaire   +2 more sources

The effect of flavopiridol on the growth of p16+ and p16− melanoma cell lines

Melanoma Research, 2003
Flavopiridol is the first cyclin-dependent kinase inhibitor to enter clinical trials. Flavopiridol has been shown to mimic, in part, the effect of the cell cycle control gene p16, which is frequently lost or mutated in malignant melanoma, making it an ideal candidate for targeted therapy in this disease.
William A, Robinson, Troy L, Miller, Elizabeth A, Harrold, Lynne T, Bemis, Benjamin M R, Brady, R Peter, Nelson   +5 more
openaire   +2 more sources

Treatment response in the neck: p16+ versus p16− oropharyngeal cancer

Journal of Medical Imaging and Radiation Oncology, 2013
AbstractIntroductionTo compare nodal response rates following chemoradiotherapy in patients with p16+ and p16− oropharyngeal squamous cell carcinoma (OPSCC).MethodsPatients with node‐positive OPSCC treated at Peter MacCallum Cancer Centre on the published phase I–III tirapazamine trials were identified.
Daisy, Mak, Rodney J, Hicks, Danny, Rischin, Ben, Solomon, Lester, Peters, Mathias, Bressel, Richard J, Young, June, Corry   +7 more
openaire   +2 more sources

CDKN2/p16 inactivation and p16 immunohistochemistry in astrocytic gliomas.

International Journal of Oncology, 1998
CDKN2/p16 inactivation is the most frequent alteration in the molecular regulation of G1-S transition. CDKN2/p16 homozygous deletions was studied in paraffin-embedded sections of 45 astrocytic tumours by multiplex PCR. Immunohistochemistry for p16 and proliferation marker Ki-67 MIB-1 was performed in adjacent sections; their labelling index (LI) have ...
R, Piva, P, Cavalla, S, Bortolotto, S, Cordera, R, Grosso, P, Richiardi, A, Dutto, D, Schiffer   +7 more
openaire   +2 more sources

Methylation and p16: Suppressing the suppressor

Nature Medicine, 1995
Mutations in tumour suppressors often lead to tumorigenesis. But other genetic mechanisms affecting suppressor gene expression can be just as effective (pages 686–692).
Little, M, Wainwright, B
openaire   +5 more sources

P16

Surgery for Obesity and Related Diseases, 2006
Robert A. Frankel, Candyce Kaaiai, Carlos Weber   +2 more
  +4 more sources

Expression of MDM2 and p16 in angiomyolipoma

Human Pathology, 2018
Angiomyolipoma (AML) arises primarily from the kidney but may grow into the retroperitoneal space mimicking a primary retroperitoneal tumor. Fine needle aspiration (FNA) and core needle biopsy of AML, particularly the fat-predominant variant, may be difficult to distinguish from retroperitoneal well-differentiated liposarcoma (WDLS) or lipoma. Commonly
Xiaoqi, Lin, William B, Laskin, Xinyan, Lu, Yaxia, Zhang   +3 more
openaire   +2 more sources