Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity. [PDF]
, 2020 The accumulation of senescent cells (SnCs) is a causal factor of various age-related diseases as well as some of the side effects of chemotherapy. Pharmacological elimination of SnCs (senolysis) has the potential to be developed into novel therapeutic ...
Budamagunta, Vivekananda +9 more
core +1 more source
Prognostic significance of p16 immunohistochemical expression in urothelial carcinoma
Surgical and Experimental Pathology, 2019 Background p16 is the protein product of most commonly involved gene in bladder carcinogenesis. Therefore, we performed an immunohistochemical study to evaluate association of p16 overexpression with prognostic parameters in bladder cancer.
Atif Ali Hashmi +5 more
doaj +1 more source
The Chandra Dust Scattering Halo of Galactic Center transient Swift J174540.7-290015 [PDF]
, 2017 We report the detection of a dust scattering halo around a recently discovered X-ray transient, Swift J174540.7-290015, which in early February of 2016 underwent one of the brightest outbursts (F_X ~ 5e-10 erg/cm^2/s) observed from a compact object in ...
Baganoff, F. +6 more
core +3 more sources
A study on the correlation between HPV DNA and IHC P16 expression in cervical lesions [PDF]
Zhongguo aizheng zazhiBackground and purpose: Human papilloma virus (HPV) infection status is crucial for diagnosing cervical precancerous lesions and classifying cervical cancer.
WANG Haochen, JIA Liqing, YANG Yu, WANG Qian, YU Chengli, TIAN Tian, BI Rui, TU Xiaoyu, BAI Qianming, ZHU Xiaoli, ZHOU Xiaoyan, REN Min
doaj +1 more source
Prognostic value of p16, p53, and pcna in sarcoma and an evaluation of immune infiltration
Journal of Orthopaedic Surgery and Research, 2022 Background p16, p53, and proliferating cell nuclear antigen (pcna) genes play significant roles in many chromatin modifications and have been found to be highly expressed in a variety of tumor tissues.
Dechao Cai +6 more
doaj +1 more source
Reconstructing seasonality through stable-isotope and trace-element analyses of the Proserpine stalagmite, Han-sur-Lesse cave, Belgium : indications for climate-driven changes during the last 400 years [PDF]
, 2020 Fast-growing speleothems allow for the reconstruction of palaeoclimate down to a seasonal scale. Additionally, annual lamination in some of these speleothems yields highly accurate age models for these palaeoclimate records, making these speleothems ...
Claeys, Philippe +8 more
core +2 more sources
p16, pRb, and p53 in Feline Oral Squamous Cell Carcinoma
Veterinary Sciences, 2016 Feline oral squamous cell carcinoma (FOSCC) is a highly aggressive head and neck cancer in cats, but the molecular pathogenesis of this cancer is still uncertain.
Wachiraphan Supsavhad +3 more
doaj +1 more source
BMC Cancer, 2018 Background Tumor suppressor gene p16 promoter hypermethylation has been widely studied in colorectal cancer (CRC), yet its clinicopathological significance remains controversial.
Xiaoxia Ye +10 more
doaj +1 more source
Significance of P16INK4A hypermethylation gene in primary head/neck and colorectal tumors: it is a specific tissue event? Results of a 3-year GOIM (Gruppo Oncologico dell'Italia Meridionale) prospective study [PDF]
, 2006 BACKGROUND: Methylation of the p16 promoter is one of the most frequent mechanisms of gene inactivation; its incidence is extremely variable according to the type of tumor involved.
Adamo, V. +23 more
core +1 more source
IKKβ specifically binds to P16 and phosphorylates Ser8 of P16 [PDF]
Biochemical and Biophysical Research Communications, 2010 In spite of its central roles in cell cycle progression, senescence, and aging, knowledge about the posttranslational regulation of P16 (also known as INK4A and MTS1) remains limited. While it has been reported that P16 could be phosphorylated at Ser7, Ser8, Ser140, and Ser152, the corresponding kinases have not been identified yet. Here we report that
Yi, Guo +3 more
openaire +2 more sources