Results 41 to 50 of about 44,677 (241)

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

Deregulation of HDAC1 by p25/Cdk5 in Neurotoxicity [PDF]

Neuron, 2008
Aberrant cell-cycle activity and DNA damage are emerging as important pathological components in various neurodegenerative conditions. However, their underlying mechanisms are poorly understood. Here, we show that deregulation of histone deacetylase 1 (HDAC1) activity by p25/Cdk5 induces aberrant cell-cycle activity and double-strand DNA breaks leading
Kim, Dohoon, Frank, Christopher L., Dobbin, Matthew M., Tsunemoto, Rachel K., Tu, Weihong, Peng, Peter L., Guan, Ji-Song, Lee, Byung-Hoon, Moy, Lily Y., Giusti, Paola, Broodie, Nisha, Mazitschek, Ralph, Delalle, Ivanna, Haggarty, Stephen J., Neve, Rachael L., Lu, YouMing, Tsai, Li-Huei   +16 more
openaire   +3 more sources

Ultrasonic‐Assisted Photocatalytic Conversion of Air to Nitric Acid Under Ambient Conditions

Advanced Science, EarlyView.
Ultrasound‐assisted photocatalytic air oxidation to nitrate enhances soil nitrogen fertilizer dynamics, thereby enabling improved energy conversion efficiency and sustainable agriculture. ABSTRACT The production of nitric acid (HNO3) holds significant importance in the chemical industry, and achieving direct air‐to‐HNO3 conversion with high efficiency ...
Shiming Chen, Hanlan Hong, Yunchuan Tu, Chao Zhen, Rui Zheng, Yuxi Yao, Junxiong Chen, Tianlin Wang, Xiumei Zhan, Fanhe Kong, Huazhe Yang, Gang Liu   +11 more
wiley   +1 more source

Generation of the Cdk5 activator p25 is a memory mechanism that is affected in early Alzheimer’s disease

Frontiers in Molecular Neuroscience, 2014
About 15 years ago it was proposed that generation of the truncated protein p25 contributes to toxicity in Alzheimer's disease (AD). p25 is a calcium-dependent degradation product of p35, the principal activator of cyclin-dependent kinase 5 (Cdk5).
Karl Peter eGiese
doaj   +1 more source

Impact of support characteristics and preparation method on photocatalytic activity of TiO2/ZSM-5/silica gel composite photocatalyst [PDF]

Royal Society Open Science, 2018
Titanium dioxide (Degussa P25) was supported onto two different aluminosilicate zeolites (ZSM-5) and anchored on three silica gels using two separate preparation methods to study the effect of the catalyst components and the preparation method on the ...
Emad K. Radwan, Cooper H. Langford, Gopal Achari   +2 more
doaj   +1 more source

Gamma Radiation Synthesis of Ag/P25 Nanocomposites for Efficient Photocatalytic Degradation of Organic Contaminant

Nanomaterials, 2023
Titanium dioxide (TiO2) has garnered significant attention among various photocatalysts, whereas its photocatalytic activity is limited by its wide bandgap and inefficient charge separation, making the exploration of new strategies to improve its ...
Zihua Zeng, Shuangxiao Li, Xueyan Que, Jing Peng, Jiuqiang Li, Maolin Zhai   +5 more
doaj   +1 more source

Compensatory Interplay Between Clarin‐1 and Clarin‐2 Deafness‐Associated Proteins Governs Phenotypic Variability in Hearing

Advanced Science, EarlyView.
Functional compensation between clarin‐1 and clarin‐2 in cochlear hair cells. Hearing loss associated with CLRN1 mutations shows striking phenotypic variability; however, the underlying mechanisms remain poorly understood. This study reveals that clarin‐1 and clarin‐2 function cooperatively in cochlear hair cells to sustain mechanoelectrical ...
Maureen Wentling, Aïda Yakhlef Sanchez, Nicolas Thelen, Müge Senarisoy, Maria Hogg, Steven Condamine, Andrea Lelli, Emilia Wysocka, Pranav Patni, Sandrine Vitry, Kerem Yasin Yildizhan, Sébastien Le Gal, Sylvie Nouaille, Michael R. Bowl, Marc Thiry, Didier Dulon, Sedigheh Delmaghani, Aziz El‐Amraoui   +17 more
wiley   +1 more source

Computational Simulations Identified Two Candidate Inhibitors of Cdk5/p25 to Abrogate Tau-associated Neurological Disorders

Computational and Structural Biotechnology Journal, 2019
Deregulation of Cdk5 is a hallmark in neurodegenerative diseases and its complex with p25 forms Cdk5/p25, thereby causes severe neuropathological insults.
Amir Zeb, Minky Son, Sanghwa Yoon, Ju Hyun Kim, Seok Ju Park, Keun Woo Lee   +5 more
doaj   +1 more source

Enhancement of photocatalytic activity by Z-scheme heterojunction of CaTiO3 nanocuboids and P25

Energy Reports, 2023
Photocatalysis is an interesting approach to convert solar energy into chemical energy. To achieve efficient energy conversion, a mixed photocatalyst of CaTiO3 nanocuboids and commercial anatase TiO2 nanoparticles P25 were used.
Genki Saijo, Dang Trang Nguyen, Kozo Taguchi   +2 more
doaj   +1 more source

Food inflation pass‐through from agricultural imports in a small open economy

American Journal of Agricultural Economics, EarlyView.
Abstract This paper develops a new framework for quantifying cost pass‐through in a small open economy by estimating firm‐level markup responses to agricultural import price shocks. We show theoretically that markup adjustments depend on firms' reliance on imported inputs and demand curvature, generating heterogeneous inflationary effects across firm ...
Minseong Kang, Seungki Lee
wiley   +1 more source