Results 71 to 80 of about 19,370 (214)

Re-transection of P28-injured opossum spinal cord.

, 2013
In adulthood the spinal cord of one P28-injured Monodelphis was re-transected through the centre of the injury site and allowed to recover for 3 weeks before behavioural and labelling studies were performed.
Moses Zhang (385080), Natassya M. Noor (195806), Sophie C. Whish (444208), Jessie S. Truettner (195824), W. Dalton Dietrich (195828), Peter J. Crack (330683), Benjamin J. Wheaton (195816), Katarzyna M. Dziegielewska (141625), Norman R. Saunders (141628)   +8 more
core   +1 more source

Longitudinal Phenotypic Trajectories in GNAO1‐Related Disorders: Defining Disease Progression and Clinical Profiles

Annals of Neurology, Volume 100, Issue 1, Page 154-170, July 2026.
Objective Pathogenic variants in GNAO1 cause a spectrum of epilepsy, movement disorders, and developmental impairment. Clinical heterogeneity complicates prognosis and therapeutic development. We present the first longitudinal natural history study of GNAO1‐related disorders (GNAO1‐RD) to delineate phenotypic trajectories. Methods Sixty‐six individuals
Jana Domínguez‐Carral, Ana María Domínguez Cobo, Sol Balsells, Anna Aguilar‐Ros, Chu‐Ting Chang, William G. Ludlam, Kathryn Yang, Katerina Bernardi, Micaela Chinigioli, Ainara Salazar‐Villacorta, Veronica Di Pisa, Nuria Lamagrande‐Casanova, Elena González‐Alguacil, Beatriz De la Casa‐Fages, Akihisa Okumura, Josefina Rodríguez, Ayush Agarwal, Daniela Muñoz‐Chesta, Carolina Reynoso‐Osnayo, Amy Lin, Brahim Tabarki, Jobaida Parvin, Adolfo Alberto Gallo, Andreia Forno, Fabian Maass, Johnny Montiel Blanco, Salomé Nasif, Elizabeth Jennions, Jorge Luis Ramón‐Gómez, Helene Verhelst, Juan José Nieto Barceló, Dunja Čokolić Petrović, Luz Victoria García Ruiz, Christoph van Riesen, Paulo Rego Sousa, Maria del Pilar Massaro Sanchez, Husnea Ara Khan, Wejdan Hakami, Jennifer Friedman, Iván Espinoza‐Quinteros, Monica Troncoso, Divyani Garg, Micaela Pauni, Hirokazu Kurahashi, María Concepción Miranda‐Herrero, Anna Duat‐Rodriguez, Luca Soliani, Manju A. Kurian, Angeles Schteinschnaider, Siddharth Srivastava, Darius Ebrahimi‐Fakhari, Kirill A. Martemyanov, Juan Darío Ortigoza‐Escobar   +52 more
wiley   +1 more source

Expression of the Potato Leafroll Virus ORF0 Induces Viral-Disease-like Symptoms in Transgenic Potato Plants

Molecular Plant-Microbe Interactions, 1997
The role of the open reading frame 0 (ORF0) of luteoviruses in the viral infection cycle has not been resolved, although the translation product (p28) of this ORF has been suggested to play a role in host recognition.
Frank van der Wilk, Petra Houterman, Jos Molthoff, Fabienne Hans, Ben Dekker, Johannes van den Heuvel, Harm Huttinga, Rob Goldbach   +7 more
doaj   +1 more source

Early Isoflurane Exposure Is Associated With Delayed Adolescent Neurobehavioral Deficits, Accompanied by Dysregulation of FOXG1 and EB3

Developmental Neurobiology, Volume 86, Issue 3, July 2026.
ABSTRACT Early‐life exposure to general anesthetics has been linked to long‐term neurodevelopmental risks, yet the underlying mechanisms remain unclear. Using a mouse model, we show that neonatal isoflurane exposure at Postnatal Day 7 leads to age‐dependent behavioral alterations, changes in cortical neuronal abundance and layer‐specific neuronal ...
Ke Chen, Mengdi Xia, Changhong Li, Zhenhua Ren, Xiaohui Li   +4 more
wiley   +1 more source

Additional file 1 of Replication of cowpox virus in macrophages is dependent on the host range factor p28/N1R

, 2021
Additional file 1. Mapping of the p28 loci from the sequenced recombinant viruses’ genomes to the CPXV BR WT p28 sequence derived from the CPXV BR reference sequence (NC_003663 ...
Bernd Karsten Tischer (11322425), Daniel Bourquain (11322422), Livia Schrick (3990758), Klaus Osterrieder (113132), Lars Schaade (824526), Andreas Nitsche (12987)   +5 more
core   +1 more source

The Dual Roles of Regulatory B Cells in Infection, Cancer, and Immunity

MedComm, Volume 7, Issue 7, July 2026.
Regulatory B cells maintain immune homeostasis via suppressive cytokines and surface molecules like PD‐L1. While beneficially suppressing autoimmunity and promoting transplant tolerance, these identical mechanisms detrimentally attenuate antipathogen and antitumor immune responses.
Anni Feng, Qilong Li, Ning Jiang, Qijun Chen   +3 more
wiley   +1 more source

Invitro transcription analysis of E. chaffeensis genes dnaK, groE, hup, p28-Omp14 and p28-Omp19 promoters.

, 2013
In vitro transcription analysis was performed using RNAP holoenzyme containing E. chaffeensis recombinant σ32 or σ70. The promoter segments of E. chaffeensis genes dnaK, groE, hup, p28-Omp14 and p28-Omp19 cloned upstream to the G-less cassette in pMT504
Tonia Von Ohlen (488607), Roman R. Ganta (282367), Bonto Faburay (33819), Chuanmin Cheng (282362), Huitao Liu (332688)   +4 more
core   +1 more source

Autocatalytic, Brain Tumor‐Targeting Delivery of Bardoxolone Methyl Self‐Assembled Nanoparticles for Glioblastoma Treatment

Small Science
Glioblastoma multiforme (GBM) is a formidable cancer to treat due to the lack of effective drugs that can also efficiently cross the blood–brain barrier (BBB).
Zhang Ye, Wendy C. Sheu, Huan Qu, Bin Peng, Jia Liu, Li Zhang, Fanen Yuan, Yuxin Wei, Jiangbing Zhou, Qianxue Chen, Xuan Xiao, Shenqi Zhang   +11 more
doaj   +1 more source

Effect of VEGF on Inflammatory Regulation, Neural Survival, and Functional Improvement in Rats following a Complete Spinal Cord Transection

Frontiers in Cellular Neuroscience, 2017
After complete transection of the thoracic spinal segment, neonatal rats exhibit spontaneous locomotor recovery of hindlimbs, but this recovery is not found in adult rats after similar injury. The potential mechanism related to the difference in recovery
Jing Li, Jing Li, Shuangxi Chen, Zhikai Zhao, Yunhao Luo, Yuhui Hou, Heng Li, Liumin He, Libing Zhou, Wutian Wu, Wutian Wu, Wutian Wu   +11 more
doaj   +1 more source

Endothelial Netrin‐4 regulates oligodendrocyte precursor cell proliferation and differentiation via ET‐1 signaling in preterm white matter injury

Brain Pathology, Volume 36, Issue 4, July 2026.
Our findings show early increased Netrin‐4 in mice with PWMI boosts angiogenesis and OPCs proliferation. Later, high levels hinder OPCs differentiation into mature cells, impairing myelination. It may act by stimulating ET‐1 secretion. Abstract Perinatal hypoxia–ischemia is a leading cause of preterm white matter injury (PWMI), yet mechanisms ...
Fuxing Dong, Weixing Yan, Qiqi Meng, Xueli Song, Bing Cheng, Yaping Liu, Yanan Liu, Chao Ren, Ruiqin Yao   +8 more
wiley   +1 more source