Results 71 to 80 of about 204,366 (349)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Expression of P2 nucleotide receptors varies with age and sex in murine brain microglia

Journal of Neuroinflammation, 2009
Microglia are implicated in multiple neurodegenerative disorders, many of which display sexual dimorphisms and have symptom onsets at different ages. P2 purinergic receptors are critical for regulating various microglial functions, but little is known ...
Nikodemova Maria, Crain Jessica M, Watters Jyoti J   +2 more
doaj   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

P2 receptors in atherosclerosis and postangioplasty restenosis [PDF]

Purinergic Signalling, 2006
Atherosclerosis is an immunoinflammatory process that involves complex interactions between the vessel wall and blood components and is thought to be initiated by endothelial dysfunction [1-3]. Extracellular nucleotides that are released from a variety of arterial and blood cells [4] can bind to P2 receptors and modulate proliferation and migration of ...
Seye, Cheikh I., Kong, Qiongman, Yu, Ningpu, Gonzalez, Fernando A., Erb, Laurie, Weisman, Gary A.   +5 more
openaire   +4 more sources

Neuroinflammatory responses and blood–brain barrier injury in chronic alcohol exposure: role of purinergic P2 × 7 Receptor signaling

Journal of Neuroinflammation
Alcohol consumption leads to neuroinflammation and blood‒brain barrier (BBB) damage, resulting in neurological impairment. We previously demonstrated that ethanol-induced disruption of barrier function in human brain endothelial cells was associated with
Namdev S. Togre, Naveen Mekala, Priyanka S. Bhoj, Nikhita Mogadala, Malika Winfield, Jayshil Trivedi, Deborah Grove, Sudhir Kotnala, Slava Rom, Uma Sriram, Yuri Persidsky   +10 more
doaj   +1 more source

Acute lung inflammation and ventilator-induced lung injury caused by ATP via the P2Y receptors: an experimental study

Respiratory Research, 2008
Background Extracellular adenosine 5'-triphosphate (ATP) is an endogenous signaling molecule involved in multiple biological phenomena, including inflammation. The effects of extracellular ATP in the lung have not been fully clarified.
Shime Nobuaki, Mizuta Mitsuhiko, Beppu Satoru, Ueno Hiroshi, Hashimoto Soshi, Amaya Fumimasa, Matsuyama Hiroki, Ishizaka Akitoshi, Hashimoto Satoru   +8 more
doaj   +1 more source

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

FEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc, Blaž Stres, Mirica Karlovits, Igor Karlovits, Petra Jerič, Ondrej Panák, Anja Verbič, Blaž Likozar, Uroš Novak   +8 more
wiley   +1 more source

P2 receptors in cardiovascular regulation and disease [PDF]

Purinergic Signalling, 2007
The role of ATP as an extracellular signalling molecule is now well established and evidence is accumulating that ATP and other nucleotides (ADP, UTP and UDP) play important roles in cardiovascular physiology and pathophysiology, acting via P2X (ion channel) and P2Y (G protein-coupled) receptors.
Erlinge, D, Burnstock, G
openaire   +4 more sources

Physiologic roles of P2 receptors in leukocytes

Journal of Leukocyte Biology, 2022
AbstractSince their discovery in the 1970s, purinergic receptors have been shown to play key roles in a wide variety of biologic systems and cell types. In the immune system, purinergic receptors participate in innate immunity and in the modulation of the adaptive immune response. In particular, P2 receptors, which respond to extracellular nucleotides,
Alberto, Anael Viana Pinto, Ferreira, Natiele Carla da Silva, Bonavita, André Gustavo Calvano, Nihei, Oscar Kenji, de Farias, Fernando Pires, Bisaggio, Rodrigo da Cunha, de Albuquerque, Cristóvão, Savino, Wilson, Coutinho‐Silva, Robson, Persechini, Pedro Muanis, Alves, Luiz Anastacio   +10 more
openaire   +2 more sources

Role of P2 X7 receptor during focused ultrasound induced blood brain barrier modulation

Scientific Reports
Although low-intensity focused ultrasound (LiFUS) with microbubbles is used to temporally open the blood-brain barrier (BBB), the underlying mechanism is not fully understood.
Junwon Park, Young Cheol Na, Jihyeon Lee, Younghee Seo, Hojin Kim, Sangheon Han, Byeong-Wook Song, Won Seok Chang   +7 more
doaj   +1 more source