Results 81 to 90 of about 89,570 (263)

Purinergic Signalling in Inflammatory Renal Disease

Frontiers in Physiology, 2013
Extracellular purines have a role in renal physiology and adaption to inflammation. However, inflammatory renal disease may be mediated by extracellular purines, resulting in renal injury.
Nishkantha eArulkumaran, Nishkantha eArulkumaran, Clare eTurner, Marije eSixma, Mervyn eSinger, Robert John Unwin, Frederick WK Tam   +6 more
doaj   +1 more source

Resensitization of TRPV1 channels after the P2 receptor activation in sensory neurons of spinal ganglia in rats. [PDF]

Front Cell Neurosci, 2023
Petrushenko OA, Stratiievska AO, Petrushenko MO, Lukyanetz EA.   +3 more
europepmc   +1 more source

P2 receptor web: Complexity and fine-tuning

Pharmacology & Therapeutics, 2006
The present review offers a new perspective on a family of receptors, termed P2 receptors, specific for nucleoside tri- and diphosphates of purines/pyrimidines. We emphasize here that while decoding the inputs of various related extracellular ligands, P2 receptors are a clear example of increasing biological complexity.
Volonté, Cinzia, Amadio, Susanna, D'Ambrosi, Nadia, Colpi, Monica, Burnstock, Geoffrey   +4 more
openaire   +4 more sources

A 3D Human Bone and Bone Marrow‐on‐a‐Chip Model for In Vitro Bone Remodeling and Immune Cell Maintenance

Advanced Science, EarlyView.
This study presents a human Bone (and Bone Marrow)‐on‐a‐Chip model based on native human bone scaffolds and autologous cells. Dynamic perfusion and sequential cell seeding replicate the physiological bone remodeling process in vitro, enabling the long‐term culture of functional, mature bone marrow immune subpopulations.
Nina Stelzer, Melanie‐Jasmin Ort, Kristian Händler, Emely Bortel, Ioanna Maria Dimitriou, Martin Textor, Georg N. Duda, Janosch Schoon, Uwe Marx, Uwe Kornak, Annika Winter, Bernhard Hesse, Stefanie Donner, Sebastian Hardt, Oliver Klein, Simon Reinke, Malte Spielmann, Sven Geißler   +17 more
wiley   +1 more source

How Prof. Burnstock's enthusiasm supported P2 receptor research in Germany. [PDF]

Purinergic Signal, 2021
Hausmann R, Franke H, Schmalzing G.
europepmc   +1 more source

An On‐Demand Neuromorphic Vision System Enabled by a Multi‐Paradigm Neuromorphic Device and Hierarchical Reconfigurability Designed from Device to System Level

Advanced Science, EarlyView.
An on‐demand ultra‐reconfigurable intelligent vision system with hierarchical reconfigurability from device to system levels is demonstrated. Through co‐design of a multi‐paradigm device, reconfigurable circuits, and adaptive system architecture/algorithms, the system enables seamless switching among spiking, non‐spiking, neuromorphic imaging (NI), and
Biyi Jiang, Jiayi Xu, Liang Ran, Xinhe Feng, Khalil Harrabi, Yida Li, Longyang Lin, Feichi Zhou   +7 more
wiley   +1 more source

Design and immunogenicity of a recombinant Saccharomyces boulardii secreting the P2-VP8 subunit rotavirus vaccine

Scientific Reports
Rotavirus is the leading cause of infectious diarrhea in children, and vaccination has significantly reduced the mortality rate. However, the current vaccines have not shown optimal effectiveness in developing countries.
Ibrahim Farhani, Ahad Yamchi, Hadi Razavi Nikoo, Fatemeh T. Shamsabadi, Shahriyar Abdoli, R. Holland Cheng, Majid Shahbazi   +6 more
doaj   +1 more source

That was then, this is now: the development of our knowledge and understanding of P2 receptor subtypes. [PDF]

Purinergic Signal, 2021
Kennedy C.
europepmc   +1 more source

The P2 Receptors and Congenital Platelet Function Defects [PDF]

Seminars in Thrombosis and Hemostasis, 2005
Platelets possess three P2 receptors: two (P2Y (1) and P2Y (12)) are receptors for adenosine diphosphate (ADP), and one (P2X1) is a receptor for adenosine triphosphate (ATP). The P2Y (1) receptor, which is coupled to Gq and phospholipase C-beta, is responsible for mobilization of ionized calcium from internal stores and mediates the ADP-induced ...
openaire   +4 more sources

Radiotherapy Enhances the Oncolytic Efficacy of the Novel Oncolytic Herpesvirus VG161 and Amplifies Its Antitumor Immunity in Breast Cancer

Advanced Science, EarlyView.
RT promotes VG161 replication in BC and its immunostimulatory transgenes expression, which is mediated by the upregulation of GADD34 and HVEM caused by RT. The combination therapy with VG161 and RT increases the abundances of tumor‐infiltrating lymphocytes and elicits potent systemic antitumor immunity, thereby effectively inhibiting local tumors and ...
Lijuan Lyu, Ming Yi, Ji Chen, Zeda Zhao, Ruocen Liao, Yingnan Wang, Shengtao Hu, Jun Ding, Ronghua Zhao, William Jia, Yinan Shen, Yongchang Wei, Kongming Wu, Zhijun Dai   +13 more
wiley   +1 more source