Results 101 to 110 of about 92,291 (308)

Resensitization of TRPV1 channels after the P2 receptor activation in sensory neurons of spinal ganglia in rats. [PDF]

Front Cell Neurosci, 2023
Petrushenko OA, Stratiievska AO, Petrushenko MO, Lukyanetz EA.   +3 more
europepmc   +1 more source

Purinergic receptor expression in neuronal, bladder smooth muscle and urothelial cells: characterization and inhibition by low molecular weight antagonists

, 2009
P2 purinoceptors comprise ionotropic (P2X) and metabotropic (P2Y) receptor families, responsive to nucleotide ligands and diversely distributed on virtually every mammalian cell. Most cells and tissues co-express multiple subtypes of purinoceptor; thus,
Gever, J.L.
core  

Anti-platelet therapy: ADP receptor antagonists.

, 2011
The P2Y(12) receptor on platelets with which ADP interacts has an important role in promoting platelet function and thereby platelet involvement in both haemostasis and thrombosis.
Heptinstall, S, Wijeyeratne, YD, Stan Heptinstall, Yanushi Dullewe Wijeyeratne   +3 more
core   +1 more source

Purinergic mechanosensory transduction and visceral pain [PDF]

, 2009
In this review, evidence is presented to support the hypothesis that mechanosensory transduction occurs in tubes and sacs and can initiate visceral pain.
Geoffrey Burnstock, Burnstock, G, Burnstock Geoffrey   +2 more
core   +1 more source

An On‐Demand Neuromorphic Vision System Enabled by a Multi‐Paradigm Neuromorphic Device and Hierarchical Reconfigurability Designed from Device to System Level

Advanced Science, EarlyView.
An on‐demand ultra‐reconfigurable intelligent vision system with hierarchical reconfigurability from device to system levels is demonstrated. Through co‐design of a multi‐paradigm device, reconfigurable circuits, and adaptive system architecture/algorithms, the system enables seamless switching among spiking, non‐spiking, neuromorphic imaging (NI), and
Biyi Jiang, Jiayi Xu, Liang Ran, Xinhe Feng, Khalil Harrabi, Yida Li, Longyang Lin, Feichi Zhou   +7 more
wiley   +1 more source

Purinergic Signalling in Inflammatory Renal Disease

Frontiers in Physiology, 2013
Extracellular purines have a role in renal physiology and adaption to inflammation. However, inflammatory renal disease may be mediated by extracellular purines, resulting in renal injury.
Nishkantha eArulkumaran, Nishkantha eArulkumaran, Clare eTurner, Marije eSixma, Mervyn eSinger, Robert John Unwin, Frederick WK Tam   +6 more
doaj   +1 more source

How Prof. Burnstock's enthusiasm supported P2 receptor research in Germany. [PDF]

Purinergic Signal, 2021
Hausmann R, Franke H, Schmalzing G.
europepmc   +1 more source

Rucaparib may act at multiple P2 receptor subtypes.

, 2015
Panels A and B; blockade of specific P2 receptor subtypes P2X4, P2X7 and P2Y1 in tail artery (A) and aorta (B) models failed to categorically identify the receptor subtype at which rucaparib elicits its dilatory effect.
Tracy Robson (282407), Hiu-Fung Yuen (276126), Declan O’Rourke (692863), Martin G. O’Rourke (692861), Cian M. McCrudden (276127), Chris Hagan (692868), Joe M. O’Sullivan (275899), David G. Hirst (282406), Huw D. Thomas (114714), Nicola J. Curtin (351064), Kim E. Cherry (692862), Patrick Keane (692866), Chris Shaw (285026), Kaye J. Williams (692869), Muhammad Babur (692864), Brian A. Telfer (692865), Thiagarajan Nambirajan (692867)   +16 more
core   +1 more source

Liquid Metal Nanotransformers for Drug‐Resistant Pan‐Cancer Therapy in Patient‐Derived Organoids

Advanced Science, EarlyView.
Pan‐cancer therapies are severely limited in drug‐resistance patients due to genetic mutations and other factors, resulting in poor therapeutic outcomes and constrained clinical benefit. Liquid metal nanotransformers, a new class of shape‐transformable nanomaterials capable of dramatic morphological changes, offer a promising physical strategy to ...
Xiaojie Yuan, Xuelin Wang, Zhongyao Chen, Shuo Wang, Weining Gao, Ziyi Chen, Runyang Li, Cheng Hao, Lei Zhang, Qiongqiong Zhang, Ke Zhang, Mei Yu, Qian Liu, Jingxuan Wang, Huiping Li, Simpkins Fiona, Jing Liu, Qiang Liu, Peng Liu, Yawei Hu   +19 more
wiley   +1 more source

Design and immunogenicity of a recombinant Saccharomyces boulardii secreting the P2-VP8 subunit rotavirus vaccine

Scientific Reports
Rotavirus is the leading cause of infectious diarrhea in children, and vaccination has significantly reduced the mortality rate. However, the current vaccines have not shown optimal effectiveness in developing countries.
Ibrahim Farhani, Ahad Yamchi, Hadi Razavi Nikoo, Fatemeh T. Shamsabadi, Shahriyar Abdoli, R. Holland Cheng, Majid Shahbazi   +6 more
doaj   +1 more source