Results 241 to 250 of about 56,235 (293)
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Journal of the Autonomic Nervous System, 2000
Our understanding of the actions of extracellular ATP in controlling kidney function via stimulation of P2 receptors is still at an early stage. Recently, several groups, including our own, have begun to address this subject: in this brief review, we discuss some of these effects and speculate on likely function of extracellular nucleotides in the ...
Kate A Hillman +2 more
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Our understanding of the actions of extracellular ATP in controlling kidney function via stimulation of P2 receptors is still at an early stage. Recently, several groups, including our own, have begun to address this subject: in this brief review, we discuss some of these effects and speculate on likely function of extracellular nucleotides in the ...
Kate A Hillman +2 more
openaire +3 more sources
Seminars in Thrombosis and Hemostasis, 2005
The release of nucleotides in extracellular fluids can result from cell necrosis, exocytosis of secretory granules (such as platelet dense granules), or efflux through membrane channels. In addition, recent evidence suggests that vesicular trafficking is an important pathway of nucleotide release.
Boeynaems, Jean-Marie +3 more
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The release of nucleotides in extracellular fluids can result from cell necrosis, exocytosis of secretory granules (such as platelet dense granules), or efflux through membrane channels. In addition, recent evidence suggests that vesicular trafficking is an important pathway of nucleotide release.
Boeynaems, Jean-Marie +3 more
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Trends in Pharmacological Sciences, 2006
Purinergic signalling has been implicated in many biological processes, and ATP and other extracellular nucleotides might have therapeutic potential in the treatment of cancer by signalling through P2 receptors. Different P2 receptor subtypes have been identified in a variety of different cancer types, in both primary samples of human cancer tissue and
Nicholas White, Geoffrey Burnstock
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Purinergic signalling has been implicated in many biological processes, and ATP and other extracellular nucleotides might have therapeutic potential in the treatment of cancer by signalling through P2 receptors. Different P2 receptor subtypes have been identified in a variety of different cancer types, in both primary samples of human cancer tissue and
Nicholas White, Geoffrey Burnstock
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Ocular P2 receptors and glaucoma
Neuropharmacology, 2023Adenosine triphosphate (ATP), an energy source currency in cells, is released or leaked to the extracellular space under both physiological and pathological conditions. Extracellular ATP functions as an intercellular signaling molecule through activation of purinergic P2 receptors.
Youichi, Shinozaki +3 more
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Journal of the Autonomic Nervous System, 2000
Although the emphasis in ATP research has been on postjunctional receptors, there is also evidence for presynaptic receptors regulating transmitter release in the autonomic nervous system. Recent work has attempted to identify similar mechanisms in the central nervous system.
E.M. O’Kane +3 more
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Although the emphasis in ATP research has been on postjunctional receptors, there is also evidence for presynaptic receptors regulating transmitter release in the autonomic nervous system. Recent work has attempted to identify similar mechanisms in the central nervous system.
E.M. O’Kane +3 more
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P2 receptors: intracellular signaling
Pflügers Archiv - European Journal of Physiology, 2006P2 receptors for extracellular nucleotides are divided into two categories: the ion channel receptors (P2X) and the G-protein-coupled receptors (P2Y). For the P2X receptors, signal transduction appears to be relatively simple. Upon activation by extracellular ATP, a channel comprised of P2X receptor subunits opens and allows cations to move across the ...
Gary A. Weisman +3 more
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Current Topics in Medicinal Chemistry, 2004
The current status of ligand gated ion channel P2X and G protein-coupled P2Y receptor subtypes is described. This is followed by a summary of what is known of the distribution and roles of these receptor subtypes. Potential therapeutic targets of purinoceptors are considered, including those involved in cardiovascular, nervous, respiratory ...
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The current status of ligand gated ion channel P2X and G protein-coupled P2Y receptor subtypes is described. This is followed by a summary of what is known of the distribution and roles of these receptor subtypes. Potential therapeutic targets of purinoceptors are considered, including those involved in cardiovascular, nervous, respiratory ...
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Renal P2 receptors and hypertension
Acta Physiologica, 2014AbstractThe regulation of extracellular fluid volume is a key component of blood pressure homeostasis. Long‐term blood pressure is stabilized by the acute pressure natriuresis response by which changes in renal perfusion pressure evoke corresponding changes in renal sodium excretion.
R. I. Menzies, R. J. Unwin, M. A. Bailey
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2017
Adenine nucleotides (ADP and ATP) play crucial roles in the physiological process of primary hemostasis and in the development and extension of arterial thrombosis. They act on platelets through three distinct P2 receptors: the P2Y1 and P2Y12 receptors, which are G protein-coupled ADP receptors and the P2X1 receptor, a ligand-gated cation channel ...
Christian Gachet, Béatrice Hechler
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Adenine nucleotides (ADP and ATP) play crucial roles in the physiological process of primary hemostasis and in the development and extension of arterial thrombosis. They act on platelets through three distinct P2 receptors: the P2Y1 and P2Y12 receptors, which are G protein-coupled ADP receptors and the P2X1 receptor, a ligand-gated cation channel ...
Christian Gachet, Béatrice Hechler
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The P2 Receptors in Platelet Function
Seminars in Thrombosis and Hemostasis, 2005After vessel wall injury, platelets adhere to the exposed subendothelium, are activated, and release mediators such as thromboxane A (2) (TXA (2)) and nucleotides stored at very high concentration in the so-called dense granules. Among other soluble agents, released nucleotides act in a positive feedback mechanism to cause further platelet activation ...
Béatrice Hechler +2 more
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