Results 251 to 260 of about 56,235 (293)

P2 receptors and neuronal injury

Pflügers Archiv - European Journal of Physiology, 2006
Extracellular adenosine 5'-triphosphate (ATP) was proposed to be an activity-dependent signaling molecule that regulates glia-glia and glia-neuron communications. ATP is a neurotransmitter of its own right and, in addition, a cotransmitter of other classical transmitters such as glutamate or GABA.
Peter Illes, Heike Franke, Ute Krügel
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The platelet P2 receptors in inflammation

Hämostaseologie, 2015
SummaryIn addition to their well characterized and established role in haemostasis and thrombosis, platelets contribute to the pathogenesis of inflammation. Adenine nucleotides are signalling molecules that regulate the function of virtually every cell in the body, by interacting with P2 receptors.
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Purinergic (P2) Receptors in the Kidney

2003
Publisher Summary This chapter focuses on renal P2 receptors and their relationship to the renal effects of adenosine triphosphate (ATP). It also focuses on the nonvascular P2 receptors of renal epithelia. The effects of adenosine on renal function, the distribution of its P1 (A 1–3 subtypes) receptors in kidney tissue, and the potential of this ...
Leipziger, J., Bailey, M.A., Unwin, R.J.
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Extracellular ATP, P2 receptors, and inflammation

Drug Development Research, 2003
AbstractOver the past few years, P2 receptors have emerged as new potential players in the early phases of inflammation in their function of chemotactic receptors, triggers of proinflammatory cytokine release, and cytotoxic molecules. However, more recent data suggest that the role of P2 receptors in immunity is much more widespread and touches the ...
DI VIRGILIO, Francesco, FERRARI, Davide, IDZKO M., PANTHER E., NORGAUER J., LA SALA A., GIROLOMONI G.   +6 more
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P2-Pyrimidinergic Receptors and Their Ligands

Current Pharmaceutical Design, 2002
Pyrimidine nucleotides, including UTP, UDP and UDP-glucose, are important signaling molecules which activate G protein-coupled membrane receptors of the P2Y family. Four distinct pyrimidine nucleotide-sensitive P2Y receptor subtypes have been cloned, P2Y(2), P2Y(4), P2Y(6) and P2Y(14).
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P2 receptors in the murine gastrointestinal tract

Neuropharmacology, 2002
The actions of adenosine, adenosine 5'-triphosphate (ATP), 2-methylthio adenosine diphosphate ADP (2-MeSADP), 2-methylthio ATP (2-MeSATP), alpha,beta-methylene ATP (alpha,beta-meATP) and uridine triphosphate (UTP) on isolated segments of mouse stomach (fundus), duodenum, ileum and colon were investigated. The localization of P2Y(1), P2Y(2), P2Y(4), P2X(
GIARONI, CRISTINA, KNIGHT G. E., RUAN H. Z., GLASS R., BARDINI M., LECCHINI, SERGIO, FRIGO, GIANMARIO, BURNSTOCK G.   +7 more
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Adventures in the pharmacological analysis of P2 receptors

Journal of the Autonomic Nervous System, 2000
The pharmacological classification of P2 receptors owes its origin to the pioneering efforts of Geoff Burnstock and those who followed him, research that was conducted primarily in physiological experimental systems. Over recent years, the techniques of molecular biology have been increasingly applied in the study of P2 receptors while, at the same ...
Fagura, M.S., Jarvis, Gavin, Dougall, I.G., Leff, P.   +3 more
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Agonists and antagonists for P2 receptors.

Novartis Foundation symposium, 2006
Recent work has identified nucleotide agonists selective for P2Y1, P2Y2 and P2Y6 receptors and nucleotide antagonists selective for P2Y1, P2Y12 and P2X1 receptors. Selective non-nucleotide antagonists have been reported for P2Y1, P2Y2, P2Y6, P2Y12, P2Y13, P2X(2/3)/P2X3 and P2X7 receptors.
Pedro Besada, Bhalchandra V. Joshi, Liaman K. Mamedova, Stefano Costanzi, Andrei A. Ivanov, Hyojin Ko, Dae Hong Shin, Kenneth A. Jacobson   +7 more
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The P2 Nucleotide Receptors

1998
Part I. Historical Perspectives of P2 Nucleotide Receptors. History of Extracellular Nucleotides and Their Receptors, G. Burnstock. Part II. Pharmacological and Molecular Characterization of P2 Nucleotide Receptors. P2x Receptors: Cloned and Expressed, R. J. Evans, A. Surprenant, and R. A. North.
Gary A. Weisman, John T. Turner, Jeffrey S. Fedan   +2 more
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P2 nucleotide receptors in osteoclasts

Drug Development Research, 2001
AbstractOsteoclasts are large, multinucleated cells responsible for the resorption of bone and other mineralized tissues. Whereas low concentrations of extracellular ATP stimulate osteoclast formation and resorptive activity, high concentrations inhibit osteoclast formation.
Lin N. Naemsch, Xiaobing Du, Stephen M. Sims, S. Jeffrey Dixon   +3 more
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