Results 281 to 290 of about 135,603 (303)
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Seminars in Thrombosis and Hemostasis, 2005
The release of nucleotides in extracellular fluids can result from cell necrosis, exocytosis of secretory granules (such as platelet dense granules), or efflux through membrane channels. In addition, recent evidence suggests that vesicular trafficking is an important pathway of nucleotide release.
Boeynaems, Jean-Marie +3 more
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The release of nucleotides in extracellular fluids can result from cell necrosis, exocytosis of secretory granules (such as platelet dense granules), or efflux through membrane channels. In addition, recent evidence suggests that vesicular trafficking is an important pathway of nucleotide release.
Boeynaems, Jean-Marie +3 more
openaire +2 more sources
P2 receptors and neuronal injury
Pflügers Archiv - European Journal of Physiology, 2006Extracellular adenosine 5'-triphosphate (ATP) was proposed to be an activity-dependent signaling molecule that regulates glia-glia and glia-neuron communications. ATP is a neurotransmitter of its own right and, in addition, a cotransmitter of other classical transmitters such as glutamate or GABA.
Heike, Franke +2 more
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Current Topics in Medicinal Chemistry, 2004
The current status of ligand gated ion channel P2X and G protein-coupled P2Y receptor subtypes is described. This is followed by a summary of what is known of the distribution and roles of these receptor subtypes. Potential therapeutic targets of purinoceptors are considered, including those involved in cardiovascular, nervous, respiratory ...
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The current status of ligand gated ion channel P2X and G protein-coupled P2Y receptor subtypes is described. This is followed by a summary of what is known of the distribution and roles of these receptor subtypes. Potential therapeutic targets of purinoceptors are considered, including those involved in cardiovascular, nervous, respiratory ...
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Salivary Gland P2 Nucleotide Receptors
Critical Reviews in Oral Biology & Medicine, 1999The effects of ATP on salivary glands have been recognized since 1982. Functional and pharmacological studies of the P2 nucleotide receptors that mediate the effects of ATP and other extracellular nucleotides have been supported by the cloning of receptor cDNAs, by the expression of the receptor proteins, and by the identification in salivary gland ...
J T, Turner +3 more
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Extracellular ATP, P2 receptors, and inflammation
Drug Development Research, 2003AbstractOver the past few years, P2 receptors have emerged as new potential players in the early phases of inflammation in their function of chemotactic receptors, triggers of proinflammatory cytokine release, and cytotoxic molecules. However, more recent data suggest that the role of P2 receptors in immunity is much more widespread and touches the ...
Di Virgilio F. +6 more
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2017
Adenine nucleotides (ADP and ATP) play crucial roles in the physiological process of primary hemostasis and in the development and extension of arterial thrombosis. They act on platelets through three distinct P2 receptors: the P2Y1 and P2Y12 receptors, which are G protein-coupled ADP receptors and the P2X1 receptor, a ligand-gated cation channel ...
Béatrice Hechler, Christian Gachet
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Adenine nucleotides (ADP and ATP) play crucial roles in the physiological process of primary hemostasis and in the development and extension of arterial thrombosis. They act on platelets through three distinct P2 receptors: the P2Y1 and P2Y12 receptors, which are G protein-coupled ADP receptors and the P2X1 receptor, a ligand-gated cation channel ...
Béatrice Hechler, Christian Gachet
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The Platelet P2 Receptors in Thrombosis
Seminars in Thrombosis and Hemostasis, 2005Adenosine diphosphate (ADP) and adenosine triphosphate (ATP) play a crucial role in hemostasis and thrombosis, and their receptors are potential targets for antithrombotic drugs. The ATP-gated channel P2X (1) and the two G protein-coupled P2Y (1) and P2Y (12) ADP receptors selectively contribute to platelet aggregation.
Christian, Gachet, Béatrice, Hechler
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The P2 Receptors in Platelet Function
Seminars in Thrombosis and Hemostasis, 2005After vessel wall injury, platelets adhere to the exposed subendothelium, are activated, and release mediators such as thromboxane A (2) (TXA (2)) and nucleotides stored at very high concentration in the so-called dense granules. Among other soluble agents, released nucleotides act in a positive feedback mechanism to cause further platelet activation ...
Béatrice, Hechler +2 more
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P2 nucleotide receptors in osteoclasts
Drug Development Research, 2001AbstractOsteoclasts are large, multinucleated cells responsible for the resorption of bone and other mineralized tissues. Whereas low concentrations of extracellular ATP stimulate osteoclast formation and resorptive activity, high concentrations inhibit osteoclast formation.
Lin N. Naemsch +3 more
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The platelet P2 receptors in inflammation
Hämostaseologie, 2015SummaryIn addition to their well characterized and established role in haemostasis and thrombosis, platelets contribute to the pathogenesis of inflammation. Adenine nucleotides are signalling molecules that regulate the function of virtually every cell in the body, by interacting with P2 receptors.
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