Results 91 to 100 of about 39,255 (248)
Atp4- Activates P2x Receptors [PDF]
Biophysical Journal, 2011 P2X receptors are non-selective cation channels that are involved in many important physiological processes, including neurotransmission and inflammation. Extracellular ATP released from synaptic vesicles or damaged tissues has been demonstrated to be the ligand for activating P2X receptors.
Shai D. Silberberg +2 more
openaire +2 more sources
Antidepressants inhibit P2X4 receptor function: a possible involvement in neuropathic pain relief
Molecular Pain, 2009 Background Neuropathic pain is characterized by pain hypersensitivity to innocuous stimuli (tactile allodynia) that is nearly always resistant to known treatments such as non-steroidal anti-inflammatory drugs or even opioids.
Tozaki-Saitoh Hidetoshi +5 more
doaj +1 more source
Dual functions of SNAP25 in mouse taste buds
The Journal of Physiology, EarlyView.Abstract figure legend Conditional knockout of Snap25 in taste cells leads to a marked reduction in the number of sour‐responsive Type III cells in both fungiform and circumvallete papillae of mice. In behavioral assays, Snap25/Trpv1 double knockout mice display increased licking to sour tastants, suggesting impaired aversive responses.
Kengo Horie +6 more
wiley +1 more source
Decoherence Effects in Reactive Scattering
, 2005 Decoherence effects on quantum and classical dynamics in reactive scattering are examined using a Caldeira-Leggett type model. Through a study of dynamics of the collinear H+H2 reaction and the transmission over simple one-dimensional barrier potentials,
Heekyung Han +4 more
core +1 more source
Comparative analysis of P2X1, P2X2, P2X3, and P2X4 receptor subunits in rat nodose ganglion neurons.
PLoS ONE, 2014 Nodose ganglion (NG) neurons are visceral primary sensory neurons. The transmission and regulation of visceral sensation is mediated mainly by the P2X purinoceptor (P2X receptor).
Lizhao Wang +4 more
doaj +1 more source
British Journal of Pharmacology, Volume 182, Issue 17, Page 4058-4079, September 2025.Abstract Background and Purpose Morphine is among the most powerful analgesic, but its long‐term use can cause tolerance. Synaptic ATP supply is critical for maintaining synaptic transmission. Microtubule‐based mitochondrial transport ensures synaptic energy supply.
Zheng Li +9 more
wiley +1 more source
Journal of Neuroinflammation, 2012 Background The cerebral microvascular occlusion elicits microvascular injury which mimics the different degrees of stroke severity observed in patients, but the mechanisms underlying these embolic injuries are far from understood.
Lu Ying-mei +8 more
doaj +1 more source
Pharmacology Research &Perspectives, Volume 13, Issue 4, August 2025.NLRP3 Inflammasome activation drives inflammatory responses through the production and activation of pro‐inflammatory cytokines. Repurposing sulphonylureas and their derivatives to target NLRP3 may act as adjunct therapeutics for autoimmune conditions. ABSTRACT A rapid and cost‐effective arm of the drug discovery and development process is finding new ...
Jasen Elford +4 more
wiley +1 more source
Acta Ophthalmologica, Volume 103, Issue 5, Page 586-608, August 2025.Abstract Purpose To provide an overview of artificial tears marketed in the following Nordic countries: Denmark, Finland, Norway, Iceland and Sweden. Furthermore, this review aimed to highlight the different preservatives and other constituents found in artificial tears in the Nordic market, focussing on adverse effects.
K. N. Mikha +9 more
wiley +1 more source
Opioid receptors in cardiovascular function
British Journal of Pharmacology, Volume 182, Issue 16, Page 3710-3725, August 2025.Opioid receptors are G protein‐coupled receptors expressed by various cells in the heart, including myocytes and nerve fibres, and play a crucial role in modulating cardiac function. These receptors influence neural transmission, heart rate and myocyte contractility, offering cardioprotection.
Venkatesh Katari +4 more
wiley +1 more source