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P2X receptors in peripheral neurons

Progress in Neurobiology, 2001
P2X receptors are a family of ligand-gated ion channels, activated by extracellular ATP. The seven subunits cloned (P2X1-7) can assemble to form homomeric and heteromeric receptors. Peripheral neurons of neural crest origin (e.g. those in dorsal root, trigeminal, sympathetic and enteric ganglia) and placodal origin (e.g.
Geoffrey Burnstock   +2 more
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Molecular Physiology of P2X Receptors

Physiological Reviews, 2002
P2X receptors are membrane ion channels that open in response to the binding of extracellular ATP. Seven genes in vertebrates encode P2X receptor subunits, which are 40–50% identical in amino acid sequence. Each subunit has two transmembrane domains, separated by an extracellular domain (∼280 amino acids). Channels form as multimers of several subunits.
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New insights on P2X purinoceptors

Naunyn-Schmiedeberg's Archives of Pharmacology, 1995
Significant advances in understanding of P2X purinoceptor pharmacology have been made in the last few years. The limitations of nucleotide agonists as drug tools have now been amply demonstrated. Fortunately, inhibitors of the degrading ecto-ATPase enzymes are becoming available and it has become apparent that the complete removal of all divalent ...
Annmarie Surprenant   +6 more
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P2X Receptors in Epithelia

2015
P2X receptors are ubiquitously expressed in all epithelial tissues, but their functional roles are less well studied. Here we review the current state of knowledge by focusing on functional effects of P2X receptor in secretory and in absorptive tissues. In glandular tissue like the parotid gland, basolateral P2X receptors stimulate ion secretion via an
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P2X Receptors and Pain

2013
P2X receptors are ATP-gated channels and form the third major family of ligand-gated channels. Unlike other neurotransmitter-gated channels, P2X receptors have a widespread distribution outside the brain and are involved in many physiological functions. A main function associated to P2X receptors is chronic pain.
Lauriane Ulmann   +3 more
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P2X Receptor Activation

2017
Extracellular ATP-gated P2X receptors are trimeric non-selective cation channels important for many physiological events including immune response and neural transmission. These receptors belong to a unique class of ligand-gated ion channels composed of only six transmembrane helices and a relatively small extracellular domain that harbors three ATP ...
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P2X purinoceptors and sensory transmission

Pflügers Archiv - European Journal of Physiology, 2006
The involvement of P2X purinoreceptors (P2X receptors) in somatosensory transmission is herein reviewed with a focus on those receptors that are expressed on sensory neurons to elucidate their roles in the initiation of sensory excitation from primary afferent neurons, in modulating synaptic transmission at the first sensory synapses formed between ...
Jianguo G. Gu, Terumasa Nakatsuka
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Purine Ionotropic (P2X) Receptors

Current Pharmaceutical Design, 2007
Purinergic signaling is involved in the proper functioning of virtually all organs of the body. Although in some cases purines have a major influence on physiological functions (e.g. thrombocyte aggregation), more often they are just background modulators contributing to fine tuning of biological events.
Peter Illes   +2 more
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P2X receptors and synaptic plasticity

Neuroscience, 2009
Adenosine triphosphate (ATP) is released in many synapses in the CNS either together with other neurotransmitters, such as glutamate and GABA, or on its own. Postsynaptic action of ATP is mediated through metabotropic P2Y and ionotropic P2X receptors abundantly expressed in neural cells.
Ulyana Lalo   +4 more
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P2X receptors in the gut [PDF]

open access: possibleWiley Interdisciplinary Reviews: Membrane Transport and Signaling, 2011
AbstractPurinergic transmission, which uses ATP and its derivatives as extracellular signaling molecules, is widely distributed throughout all tissues and systems, including the gastrointestinal system. Ionotropic P2X purinoceptors have been identified in various parts of the enteric nervous system, including myenteric, submucosal motor, sensory, and ...
openaire   +1 more source

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