Results 61 to 70 of about 39,255 (248)

Activity Analysis of the P2X Receptor Antagonist PPADS against Signal Transducer and Activator of Transcription Proteins

ChemBioChem, EarlyView.
The P2X receptor antagonist PPADS possesses activity against members of the signal transducer and activator of transcription (STAT) family of transcription factors, in particular STAT4, STAT5a, and STAT5b. PPADS protects STAT4 and STAT5a/STAT5b from thermal degradation in cell lysates to a higher extent than STAT3.
Angela Berg, Martin Gräber, Thorsten Berg   +2 more
wiley   +1 more source

Strong subadditivity and the covariant holographic entanglement entropy formula

, 2012
Headrick and Takayanagi showed that the Ryu-Takayanagi holographic entanglement entropy formula generally obeys the strong subadditivity (SSA) inequality, a fundamental property of entropy.
A Allais, A Wehrl, C Holzhey, DV Fursaev, J Abajo-Arrastia, J Aparicio, J Boer de, Jianyang He, L-Y Hung, M Headrick, M Headrick, Matthew Headrick, P Calabrese, R Bousso, R Bousso, RC Myers, Robert Callan, S Ryu, S Ryu, T Albash, V Balasubramanian, V Balasubramanian, V Balasubramanian, VE Hubeny   +23 more
core   +1 more source

Familial hemiplegic migraine Ca_V2.1 channel mutation R192Q enhances ATP-gated P2X₃ receptor activity of mouse sensory ganglion neurons mediating trigeminal pain

Molecular Pain, 2010
Background The R192Q mutation of the CACNA1A gene, encoding for the α1 subunit of voltage-gated P/Q Ca2+ channels (Cav2.1), is associated with familial hemiplegic migraine-1.
Nair Asha, Simonetti Manuela, Birsa Nicol, Ferrari Michel D, van den Maagdenberg Arn MJM, Giniatullin Rashid, Nistri Andrea, Fabbretti Elsa   +7 more
doaj   +1 more source

Adrenergic Control of P2Y6 Receptor‐Dependent Phagocytosis in Rodent and Human Microglia

Glia, EarlyView.
Adrenergic signaling through ADRB2 modulates phagocytosis in microglia. Crosstalk between ADRB2 and P2Y6 receptors conserved in rodent and human microglia. ADRB2 activation inhibits both P2Y6 function and gene expression. ABSTRACT Microglia, the resident immune cells of the central nervous system (CNS), are in constant survey of their environment ...
Thomas Deluc, Ariel Ase, Marie‐France Dorion, Gilles Maussion, Yeman Tang, Rita T. M. Lo, Irina Shlaifer, Valerio E. Piscopo, Thomas M. Durcan, Stefano Stifani, Philippe Séguéla   +10 more
wiley   +1 more source

Energiezukünfte für Power-to-X-Technologien

TATuP – Zeitschrift für Technikfolgenabschätzung in Theorie und Praxis, 2019
In Power-to-X-Technologien (P2X) in Form von synthetischen Kraft- und Brennstoffen für die Energie- und Verkehrswende werden große Hoffnungen gesetzt, ob als Lösung für den Umgang mit der Volatilität der erneuerbaren Energien oder als Kraftstoffe für den
Julia Epp, Theresa Pfaff
doaj   +1 more source

Pharmacological evaluation of non‐nucleotide purine derivatives as P2X7 antagonists for the treatment of neuroinflammation in traumatic brain injury

British Journal of Pharmacology, EarlyView.
Background and purpose Traumatic brain injury (TBI) is considered to be a leading cause of mortality and disability worldwide. After TBI, innate immunity is rapidly activated in response to damage‐associated molecular patterns, such as ATP release, recognised by P2X7 receptors.
Inés Valencia, Andrea Pastor‐Martínez, Céline Decouty‐Pérez, Ana Belen Lopez‐Rodriguez, María Álvarez‐Rubal, Eva Ramos, Francesco Calzaferri, Jorge Zamorano‐Fernández, Javier Giner‐García, Alexis J. Palpán‐Flores, Víctor Rodríguez‐Domínguez, Javier Rodríguez de Cía, Borja J. Hernández‐García, Alejandro Romero, Cristóbal de los Ríos, Javier Egea   +15 more
wiley   +1 more source

P2X receptors in bone [PDF]

Wiley Interdisciplinary Reviews: Membrane Transport and Signaling, 2012
AbstractBone is a dynamic organ that from the early stages of development defines an organism's form and function and responds to the external environment, a process that continues as the organism grows and persists even once maturity is reached. The formation, growth, and integrity of bone are co‐ordinated and maintained throughout life via the finely
openaire   +2 more sources

Non-Hermitian oscillators with $T_{d}$ symmetry [PDF]

, 2014
We analyse some PT-symmetric oscillators with $T_{d}$ symmetry that depend on a potential parameter $g$. We calculate the eigenvalues and eigenfunctions for each irreducible representation and for a range of values of $g$.
Amore, Paolo, Fernández, Francisco M., Garcia, Javier   +2 more
core   +2 more sources

Evolutionary Origin of the P2X7 C-ter Region: Capture of an Ancient Ballast Domain by a P2X4-Like Gene in Ancient Jawed Vertebrates

Frontiers in Immunology, 2020
P2X purinergic receptors are extracellular ATP-gated ion channel receptors present on the cell plasma membrane. P2X receptors have been found in Metazoa, fungi, amoebas, and in plants.
Airi Rump, Olli Pekka Smolander, Sirje Rüütel Boudinot, Jean M. Kanellopoulos, Pierre Boudinot   +4 more
doaj   +1 more source

Operation of Power-to-X-Related Processes Based on Advanced Data-Driven Methods: A Comprehensive Review

Energies, 2022
This study is a systematic analysis of selected research articles about power-to-X (P2X)-related processes. The relevance of this resides in the fact that most of the world’s energy is produced using fossil fuels, which has led to a huge amount of ...
Mehar Ullah, Daniel Gutierrez-Rojas, Eero Inkeri, Tero Tynjälä, Pedro H. J. Nardelli   +4 more
doaj   +1 more source