Results 71 to 80 of about 19,677 (253)
The role of the purinergic P2X7 receptor in inflammation
Journal of Inflammation, 2007 The inflammatory process, orchestrated against a variety of injurious stimuli, is composed of three inter-related phases; initiation, propagation and resolution.
Rossi Adriano G +6 more
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend The capillary–mitochondria–ion channel (CMIC) axis scales structural resources to match functional workload. (Left) In settings of restricted energetic capacity (e.g. cortical neurons), sparse capillary networks and modest mitochondrial pools set a lower energetic ceiling, sufficient to support phasic, low‐workload excitability. (
L. Fernando Santana, Scott Earley
wiley +1 more source
BMC Immunology, 2008 Background We have previously reported that ATP treatment of M bovis-BCG infected human macrophages induces P2X7 receptor-dependent killing of intracellular mycobacteria.
Croudace Joanne E +5 more
doaj +1 more source
Atorvastatin Decreases HBx-Induced Phospho-Akt in Hepatocytes via P2X Receptors
Molecular Cancer Research, 2017 Hepatocellular carcinoma (HCC) is rated as the fifth most common malignancy and third in cancer-related deaths worldwide. Statins, HMG-CoA reductase inhibitors, are potent cholesterol-lowering drugs, and recent epidemiologic evidence suggests that ...
Aram Ghalali +3 more
semanticscholar +1 more source
Spatio‐Temporal Diversity of Calcium Activity in Microglia
Glia, Volume 74, Issue 3, March 2026.Ca2+ activity mostly occurs in microglial processes and stays localized. When it spreads, it often shows a directional bias and is constrained by branch points. Activity strongly relies on P2Y12 receptors and is shaped by neuronal activity. ABSTRACT Microglia, the brain's innate immune cells, possess complex, highly motile branched processes. These act
Hiroshi Horiuchi +3 more
wiley +1 more source
Comparative analysis of P2X1, P2X2, P2X3, and P2X4 receptor subunits in rat nodose ganglion neurons.
PLoS ONE, 2014 Nodose ganglion (NG) neurons are visceral primary sensory neurons. The transmission and regulation of visceral sensation is mediated mainly by the P2X purinoceptor (P2X receptor).
Lizhao Wang +4 more
doaj +1 more source
Insights into the channel gating of P2X receptors from structures, dynamics and small molecules
Acta Pharmacologica Sinica, 2016 P2X receptors, as ATP-gated non-selective trimeric ion channels, are permeable to Na+, K+ and Ca2+. Comparing with other ligand-gated ion channel families, P2X receptors are distinct in their unique gating properties and pathophysiological roles, and ...
Jin Wang, Ye Yu
semanticscholar +1 more source
Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.This review systematically deconstructs the pathological efferocytic—metabolic axis in tumours, framing it as a three‐stage, self‐reinforcing cycle: from metabolite‐driven macrophage recruitment, through hijacked surface recognition, to post‐phagocytic metabolic reprogramming that locks in immunosuppression.
Qianlu Yang, Jie Yan, Qianxi Yang
wiley +1 more source
Journal of Pharmacological Sciences, 2004 We reported previously that intracerebroventricular (i.c.v.) administration of P2X-receptor agonists produced antinociception and the effect was attenuated by i.c.v. pretreatment with β2-adrenergic receptor antagonists.
Masato Fukui +5 more
doaj +1 more source
Nociceptive transmission and modulation via P2X receptors in central pain syndrome
Molecular Brain, 2016 Painful sensations are some of the most frequent complaints of patients who are admitted to local medical clinics. Persistent pain varies according to its causes, often resulting from local tissue damage or inflammation.
Yung-Hui Kuan, B. Shyu
semanticscholar +1 more source