Results 71 to 80 of about 39,255 (248)
British Journal of Pharmacology, EarlyView.Abstract Background and purpose Positive allosteric modulation of the P2X4 receptor is a potential route to providing cardiovascular benefit through enhancing flow‐dependent arterial vasodilation and providing cardioprotection. However, ligands that selectively enhance P2X4 activity are absent.
Jessica L. Meades +4 more
wiley +1 more source
Identification of atropine-and P2X1 receptor antagonist-reistant, neurogenic contractions of the urinary bladder [PDF]
, 2007 Acetylcholine and ATP are excitatory cotransmitters in parasympathetic nerves. We used P2X1 receptor antagonists to further characterize the purinergic component of neurotransmission in isolated detrusor muscle of guinea pig urinary bladder.
Gallagher, Gemma +3 more
core +1 more source
Advances in Applied Energy, 2023 This paper analyzes the operation of an energy hub on a community level with an integrated P2X facility and with access to energy markets. In our case, P2X allows converting power to hydrogen, heat, methane, or back to power.
Yi Wan +5 more
doaj
Journal of Neuroinflammation, 2010 Background During pathology of the nervous system, increased extracellular ATP acts both as a cytotoxic factor and pro-inflammatory mediator through P2X7 receptors. In animal models of amyotrophic lateral sclerosis (ALS), astrocytes expressing superoxide
Peluffo Hugo +4 more
doaj +1 more source
Effects of the P2RX4 antagonist BR11595 in a guinea pig model of chronic asthma
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Asthma is characterized by airway hyperresponsiveness (AHR), allergic inflammation, and airway remodelling. Although recent studies have shown that asthma pathophysiology involves P2X4 receptor activation, a potential link with chronic asthma remains to be explored.
Dan Li +13 more
wiley +1 more source
A Composite Higgs Model with Minimal Fine-Tuning I.~The Large-N and Weak-technicolor Limit [PDF]
, 2014 We suggest a criterion to minimize the amount of fine-tuning in a composite Higgs model. The paradigm of this type of model is the top-condensate model of Bardeen, Hill and Lindner (BHL).
Lane, Kenneth
core +1 more source
BMC Immunology, 2006 Background Epstein-Barr virus (EBV) infection immortalizes primary B cells in vitro and generates lymphoblastoid cell lines (LCLs), which are used for several purposes in immunological and genetic studies. Purinergic receptors, consisting of P2X and P2Y,
Kim Jun Woo +4 more
doaj +1 more source
Activation of P2X(7) receptor by ATP plays an important role in regulating inflammatory responses during acute viral infection. [PDF]
PLoS ONE, 2012 Acute viral infection causes damages to the host due to uncontrolled viral replication but even replication deficient viral vectors can induce systemic inflammatory responses.
Benjamin H Lee +5 more
doaj +1 more source
Ion permeation pathway within the internal pore of P2X receptor channels
eLife, 2023 P2X receptor channels are trimeric ATP-activated ion channels expressed in neuronal and non-neuronal cells that are attractive therapeutic targets for human disorders.
Stephanie W Tam +3 more
doaj +1 more source
, 2005 We consider the effects of a light quark mass in the soft-collinear effective theory (SCET) and we apply them to B -> X_s gamma in the endpoint region. We find that the reparameterization invariance can be extended by including the collinear quark mass ...
Chay, Junegone +2 more
core +1 more source