Results 131 to 140 of about 25,852 (233)

Platelet P2Y12 receptor influences the vessel wall response to arterial injury and thrombosis [PDF]

, 2009
Background— Platelets are believed to play an important role in atherogenesis and the vessel response to vascular injury. The P2Y12 receptor (P2Y12) plays a central role in amplifying platelet aggregation, dense granule and α-granule secretion, P ...
Crosdale, D. J., Francis, S. E., Evans, David, Judge, H. M., Jackman, L. E., Chamberlain, J., Norman, K. E., Jetha, K., Storey, R. F.   +8 more
core  

Molecular mechanisms of agonist independent internalisation of the P2Y12 purinoreceptor [PDF]

, 2012
The management of G protein-coupled receptor trafficking is essential for the normal function of these receptors. The P2Y12 purinoceptor plays an essential role in the platelet aggregation response, and has been shown to desensitise and rapidly ...
Stanton, Ian Geoffrey
core  

High-mobility group box 1 increases platelet surface P2Y12 and platelet activation in sickle cell disease

JCI Insight
Thrombosis and inflammation are intimately linked and synergistically contribute to the pathogenesis of numerous thromboinflammatory diseases, including sickle cell disease (SCD).
Deirdre Nolfi-Donegan, Gowtham K. Annarapu, Claudette St. Croix, Michael Calderon, Cheryl A. Hillery, Sruti Shiva   +5 more
doaj   +1 more source

Peripheral Sympathetic Sprouting Drives Neuropathic Pain via Spinal Microglial P2Y12 Activation in a Rat Spinal Nerve Ligation Model. [PDF]

J Pain Res
Yu T, Huang H, Li Z, Yan H.
europepmc   +1 more source

The DRY motif at work: the P2Y12 receptor case [PDF]

Journal of Thrombosis and Haemostasis, 2014
G. Rovati, V. Capra
openaire   +2 more sources

Antithrombotic Therapy in Primary and Secondary Prevention of Coronary Artery Disease. [PDF]

J Clin Med
Di Leo G, Spagnolo M, Giacoppo D, Greco A, Capodanno D.   +4 more
europepmc   +1 more source

Is Aspirin Still Indispensable After PCI-Rethinking Dual Antiplatelet Therapy in Contemporary Practice. [PDF]

J Cardiovasc Dev Dis
Yadav K, Ahmed SES, Abdelgader M, Khalid R, Veerasamy M, Das A, Bulluck H.   +6 more
europepmc   +1 more source

Clopidogrel, an ADP-P2Y12 Receptor Antagonist, Is Associated With Lower Opioid Consumption and a Reduced Incidence of Delirium in Cancer Patients Receiving Chemotherapy: A Nationwide Retrospective Cohort Study in Japan. [PDF]

Neuropsychopharmacol Rep
Abe H, Inoue R, Kogure T, Tsuchida R, Owada H, Sudo Y, Yokoshima Y, Matsui H, Yasunaga H, Sumitani M.   +9 more
europepmc   +1 more source

Bleeding complications in patients with out-of-hospital cardiac arrest treated with cangrelor and oral P2Y12 inhibitors. [PDF]

Eur Heart J Acute Cardiovasc Care
Gelbenegger G, Lipa AJ, Jorda A, Zilberszac R, Heinz G, Staudinger T, Zauner C, Holzer M, Friedrich G, Plank F, Lang IM, Jilma B, Siller-Matula JM.   +12 more
europepmc   +1 more source

Comparison of P2Y₁₂ inhibitors vs. aspirin monotherapy following dual antiplatelet therapy in patients after percutaneous coronary intervention: a systematic review and meta-analysis. [PDF]

Arch Med Sci Atheroscler Dis
Kazmi MH, Dohadwala TK, Haleem SM, Thirupathy U, Sajnani P, Camila PCI, Ayyad M, Ch'ng BX, Arshad MM, Nasser IA, Mesmar A, Khawaja MN, Al-Zou'bi A'A, Chatha S, Tariq O, Zulfiqar E, Ahmed M, Ahmed R.   +17 more
europepmc   +1 more source