Results 111 to 120 of about 25,852 (233)

Microglia control the spread of neurotropic virus infection via P2Y12 signalling and recruit monocytes through P2Y12-independent mechanisms [PDF]

, 2018
Neurotropic herpesviruses can establish lifelong infection in humans and contribute to severe diseases including encephalitis and neurodegeneration. However, the mechanisms through which the brain's immune system recognizes and controls viral infections ...
Szabó Bálint, Baranyi Mária, Tóth Krisztina, Kovács Gábor Géza, Rózsa J. Balázs, Dénes Ádám, Webb Connor, Fekete Rebeka, Szalay Gergely, Ferenczi Szilamér, Lénárt Nikolett, Cserép Csaba, Németh Valéria, Méhes Előd, Sperlágh Beáta, Boldogkői Zsolt, Gönci Balázs, West Brian L., Orsolits Barbara, Környei Zsuzsanna, Kovács Krisztina, Kittel Ágnes, Hortobágyi Tibor, Martinecz Bernadett   +23 more
core   +1 more source

Underdiagnosed and Undertreated: Obesity and Its Cardiometabolic Burden in Swedish Clinical Practice—Insights From the AROS Database

Diabetes, Obesity and Metabolism, Volume 28, Issue 8, Page 6787-6800, August 2026.
ABSTRACT Aims To quantify real‐world diagnosis and treatment of obesity in Sweden, describe cardiometabolic comorbidity burden across obesity classes, and compare long‐term cardiovascular outcomes with the general population. Materials and Methods This population‐based cohort study used the AROS (Analysis of Real‐world data of patients with Obesity in ...
Viveca Ritsinger, Magnus Sundbom, Jonatan Dereke, Åsa Ericsson, Thomas Cars, Maria K. Svensson, Anna Norhammar   +6 more
wiley   +1 more source

Tumor‐educated platelets in cancer diagnostics and prognostics: A critical appraisal and roadmap for clinical translation

International Journal of Cancer, Volume 159, Issue 2, Page 302-319, 15 July 2026.
Abstract Tumor‐educated platelets (TEPs) are emerging as a compelling frontier in liquid biopsy, functioning as dynamic, systemic sensors that sequester and process tumor‐derived biomolecules. This interaction imprints an integrated molecular signature of malignancy—spanning the transcriptome, proteome, lipidome, and crucially, the captured genome ...
Whi‐An Kwon, Min‐Kyung Lee, Eunyong Ahn, Heeyeon Kim, Yong Sang Song, Taejin Ahn   +5 more
wiley   +1 more source

To Pretreat or Not to Pretreat (With Oral P2Y12 Antagonists)? That is the Question

Journal of the American Heart Association, 2017
The treatment of patients presenting with non‐ST‐segment elevation myocardial infarction (NSTEMI) continues to evolve. As advancing technical capabilities in the cardiac catheterization lab have expanded percutaneous revascularization options, medical treatments have also continued to progress,
Angela Lowenstern, L. Kristin Newby
openaire   +3 more sources

МЕСТО ПРАСУГРЕЛА СРЕДИ ДРУГИХ ИНГИБИТОРОВ P2Y12-РЕЦЕПТОРОВ ТРОМБОЦИТОВ [PDF]

, 2017
Platelet P2Y12-receptor inhibitors are ranked 2nd in terms of administration frequency among antiplatelet agents (after acetylsalicylic acid). Administration of such drugs is mandatory in conditions characterized by increased activation of platelets ...
Е. П. ПАНЧЕНКО, П. С. ЛАГУТА, E. P. PANCHENKO, P. S. LAGUTA   +3 more
core   +2 more sources

Temporal Trends and Short‐ and Long‐Term Mortality of People With Acute Myocardial Infarction and Rheumatoid Arthritis: A Nationwide Cohort Study

Arthritis Care &Research, Volume 78, Issue 7, Page 850-859, July 2026.
Objective We investigated whether a diagnosis of rheumatoid arthritis (RA) affects the quality of inpatient acute myocardial infarction (AMI) care and long‐term mortality post‐AMI. Methods We analyzed data from 784,091 adults, 6,047 with a diagnosis of RA, from England and Wales hospitalized with AMI between 2005 and 2019 from the Myocardial Ischaemia ...
Megan Butler, Nicholas Weight, Muhammad Rashid, Rodrigo Bagur, Purvi Parwani, Samantha Hider, Edward Roddy, Robert Butler, Mamas A. Mamas   +8 more
wiley   +1 more source

P2Y12 receptor-mediated activation of spinal microglia and p38MAPK pathway contribute to cancer-induced bone pain [PDF]

, 2017
Mingjuan Liu,1 Ming Yao,1,2 Hanqi Wang,1 Longsheng Xu,1 Ying Zheng,1 Bing Huang,1 Huadong Ni,1 Shijie Xu,1 Xuyan Zhou,1 Qingquan Lian2 1Department of Anesthesiology and Pain Medicine, The First Hospital of Jiaxing, The First Affiliated Hospital of ...
Zheng Y, Yao M, Wang HQ, Xu LS, Xu SJ, Zhou XY, Liu MJ, Lian QQ, Ni HD, Huang B   +9 more
core  

Influence of the Residual Gensini Score on Prognosis of Patients With ST‐Elevation Myocardial Infarction

Catheterization and Cardiovascular Interventions, Volume 108, Issue 1, Page 76-83, July 1, 2026.
ABSTRACT Background The residual Gensini score (rGS) was developed to quantify the severity of coronary atheroma burden after coronary revascularisation. The predictive value of the rGS for clinical outcomes in patients with ST‐segment elevation myocardial infarction (STEMI) remains unexplored.
Batric Popovic, Nassima Djaballah, Mirela Tomic, Renaud Fay, Victorine Fraichot, Florian Eggenspieler, Pierre Adrien Metzdorf, Jeanne Varlot, Edoardo Camenzind   +8 more
wiley   +1 more source

Real-time platelet P2Y12 receptor occupancy as a promising pharmacodynamics biomarker for bridging the gap between PK/PD of clopidogrel therapy

Acta Pharmaceutica Sinica B
Clopidogrel effectively inhibits platelet aggregation in response to ADP by irreversibly binding to the platelet P2Y12 receptor through its active metabolite. However, the observed discrepancies between the pharmacokinetics (PK) and pharmacodynamics (PD)
Haipeng Li, Yueming Gu, Yumeng Zhao, Aiyun Xu, Dong Sun, Jingkai Gu   +5 more
doaj   +1 more source

Antiplatelet Therapy Changes for Patients With Myocardial Infarction With Recurrent Ischemic Events: Insights Into Contemporary Practice From the TRANSLATE‐ACS (Treatment With ADP Receptor Inhibitors: Longitudinal Assessment of Treatment Patterns and Events After Acute Coronary Syndrome) Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundGuidelines recommend P2Y12 inhibitor therapy for 1 year after myocardial infarction (MI), yet little guidance is provided on antiplatelet management for patients with recurrent ischemic events during that year.
Alexander C. Fanaroff, Lisa A. Kaltenbach, Eric D. Peterson, Mohammed W. Akhter, Mark B. Effron, Timothy D. Henry, Tracy Y. Wang   +6 more
doaj   +1 more source