Results 181 to 190 of about 26,462 (230)

Synthesis, preclinical evaluation and pilot clinical study of a P2Y₁₂ receptor targeting radiotracer [¹⁸F]QTFT for imaging brain disorders by visualizing anti-inflammatory microglia. [PDF]

Acta Pharm Sin B
Yao B, Kong Y, Li J, Xu F, Deng Y, Chen Y, Chen Y, Chen J, Xu M, Zhu X, Chen L, Xie F, Zhang X, Wang C, Li C.   +14 more
europepmc   +1 more source

Selective Inhibition of P2Y₁ and P2Y₁₂ Receptor Signal Pathways in Platelet Aggregation in Transgenic Cell Lines and Rats by Potassium 2-(1-Hydroxypentyl)-Benzoate, Puerarin and Salvianolic Acid B. [PDF]

CNS Neurosci Ther
Li Y, Wang W, Cai J, Feng N, Xu S, Wang L, Wang X.   +6 more
europepmc   +1 more source

Ticagrelor inverse agonist activity at the P2Y₁₂ receptor is non-reversible versus its endogenous agonist adenosine 5´-diphosphate. [PDF]

Br J Pharmacol
Khalil J, Dimofte T, Roberts T, Keith M, Amaradasa K, Hindle MS, Bancroft S, Hutchinson JL, Naseem K, Johnson T, Mundell SJ.   +10 more
europepmc   +1 more source

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The Function and Regulation of Platelet P2Y12 Receptor

Cardiovascular Drugs and Therapy, 2021
In addition to the key role in hemostasis and thrombosis, platelets have also been wildly acknowledged as immune regulatory cells and involving in the pathogenesis of inflammation-related diseases. Since purine receptor P2Y12 plays a crucial role in platelet activation, P2Y12 antagonists such as clopidogrel, prasugrel, and ticagrelor have been widely ...
Xiaohua Li, Guoxing Zhang, Xia Cao
openaire   +2 more sources

Relationship between degree of P2Y12 receptor blockade and inhibition of P2Y12-mediated platelet function

Thrombosis and Haemostasis, 2010
SummaryThe thienopyridine P2Y12 receptor antagonists clopidogrel and prasugrel prevent arterial thrombosis and are routinely used following percutaneous coronary intervention. However, the optimal level of P2Y12 blockade to effectively inhibit platelet function is unknown.
Robert J Buckland, Robert F Storey
exaly   +3 more sources

Switching P2Y12 Receptor Inhibiting Therapies

Interventional Cardiology Clinics, 2017
Antiplatelet therapy with aspirin and a P2Y12 receptor inhibitor is the cornerstone of treatment of patients with atherothrombotic disease manifestations. Switching between P2Y12 inhibitors occurs commonly in clinical practice for a variety of reasons, including safety, efficacy, adherence, and economic considerations.
Fabiana, Rollini, Francesco, Franchi, Dominick J, Angiolillo   +2 more
openaire   +2 more sources

Role of P2Y12 Receptor in Thrombosis

2015
P2Y12 receptor is a 342 amino acid Gi-coupled receptor predominantly expressed on platelets. P2Y12 receptor is physiologically activated by ADP and inhibits adenyl cyclase (AC) to decrease cyclic AMP (cAMP) level, resulting in platelet aggregation. It also activates PI3 kinase (PI3K) pathway leading to fibrinogen receptor activation, and may protect ...
Yaqi, Zhang, Si, Zhang, Zhongren, Ding
openaire   +2 more sources

Progress in Platelet Blockers: The Target is the P2Y12 Receptor

Journal of Cardiothoracic and Vascular Anesthesia, 2013
The considerable progress in P2Y12-platelet blockers has important perioperative implications due to a family of novel agents beyond clopidogrel. Although prasugrel is more potent than clopidogrel due to more efficient hepatic metabolism, it is limited clinically by its irreversibility and bleeding risks.
Prakash A, Patel, Bernard, Lane, John G T, Augoustides   +2 more
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Purification and Functional Reconstitution of the Human P2Y12 Receptor

Molecular Pharmacology, 2003
The human P2Y12 receptor (P2Y12-R) is a member of the G protein coupled P2Y receptor family, which is intimately involved in platelet physiology. We describe here the purification and functional characterization of recombinant P2Y12-R after high-level expression from a baculovirus in Sf9 insect cells.
Erik T, Bodor, Gary L, Waldo, Shelley B, Hooks, James, Corbitt, Jose L, Boyer, T Kendall, Harden   +5 more
openaire   +2 more sources