Results 21 to 30 of about 711 (114)
The Milbank Quarterly, Volume 98, Issue 2, Page 581-617, June 2020., 2020 Policy Points For complex reasons, the promise of “precision medicine” based on molecular pathways remains unrealized for many conditions. Clinical practice guidelines (theoretically, at least) can act as “trailblazers” to introduce tests and treatments that reflect precision medicine discoveries.
ALEX RUSHFORTH, TRISHA GREENHALGH
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Oxidative Medicine and Cellular Longevity, Volume 2020, Issue 1, 2020., 2020 Cytokines and growth factors are known to play an important role in the skin wound closure process; however, in knockout organisms, the levels of these molecules can undergo changes that result in the delay or acceleration of this process. Therefore, we systematically reviewed evidence from preclinical studies about the main immunoregulatory molecules ...
Bárbara Cristina Félix Nogueira +7 more
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P311 Morpho-functional myocardial alteration during trastuzumab therapy: anything beyond cardiotoxicity? [PDF]
European Heart Journal - Cardiovascular Imaging, 2020 Abstract Background Trastuzumab (TZ) has a primary role in the therapy of HER-2 positive breast cancer but has potential negative effect on left ventricular (LV) function that define cardiotoxicity (CT).
L F Cerrito +12 more
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Investigating the Role of P311 in the Hypertrophic Scar
PLoS ONE, 2010 The mechanisms of hypertrophic scar formation are not fully understood. We previously screened the differentially expressed genes of human hypertrophic scar tissue and identified P311 gene as upregulated. As the activities of P311 in human fibroblast function are unknown, we examined the distribution of it and the effects of forced expression or ...
Jianglin Tan +9 more
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Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.A benzofuran‐triketone hybrid emerged as the most promising 4‐hydroxyphenylpyruvate inhibitor, showing the highest predicted activity and strongest binding compared to the best experimental compound. Free computational tools guided candidate selection, predicted interactions with the enzyme, and confirmed stable binding.
Luiz R. Capucho +2 more
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Abstract Book for the 27th Congress of the European Hematology Association
, 2022 HemaSphere, Volume 6, Issue S3, Page 1-4130, June 2022.
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Exploration, Volume 5, Issue 6, December 2025.This study investigates the effect of protein properties on the nanomaterial‐protein interaction and elucidates the molecular mechanisms underlying the targeted inhibition of polo‐like kinase (PLK1) by black phosphorus nanomaterials (BPNMs). The specific targeting inhibition is attributed to the intrinsic properties of both the PLK1 protein and the ...
Fangfang Liu +15 more
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Caring and Working: Developing Insights Into the World of the Working Carer
Health &Social Care in the Community, Volume 2025, Issue 1, 2025.This paper reports on a study exploring the experiences of working carers in the South of England—part of a larger research project exploring carers’ needs, experiences and ideas about improving carer involvement in research. The purpose of this element of the project was to understand the experience of being in paid employment whilst providing unpaid ...
Andy Pulman +2 more
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Mathematical Problems in Engineering, Volume 2019, Issue 1, 2019., 2019 This paper studies a flexible flowshop scheduling problem with step‐deteriorating jobs and sequence‐dependent setup times (FFSP‐SDJ&SDST) where there are multiple unrelated parallel machines at each stage. The actual processing time of each job is modeled as a step function of its starting time. An integer programming model is first formulated with the
Hua Xuan +3 more
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Clinical Genetics, Volume 106, Issue 3, Page 258-266, September 2024.The objective of this study is to clarify the genetic foundation of hereditary retinal diseases in a Turkish population by gathering data from 354 probands. Using the panel‐based NGS method, 103 genes were assessed, resulting in a diagnostic success rate of 58.1%.
Busra Ozguc Caliskan +5 more
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