Results 51 to 60 of about 68,477 (191)

Genetic and pharmacologic p32-inhibition rescue CHCHD2-linked Parkinson’s disease phenotypes in vivo and in cell models

Journal of Biomedical Science
Background Mutations in CHCHD2 have been linked to Parkinson’s disease, however, their exact pathophysiologic roles are unclear. The p32 protein has been suggested to interact with CHCHD2, however, the physiological functions of such interaction in the ...
Murni Tio, Rujing Wen, Cai Ning Choo, Jian Bin Tan, Aaron Chua, Bin Xiao, Jeyapriya Rajameenakshi Sundaram, Christine Hui Shan Chan, Eng-King Tan   +8 more
doaj   +1 more source

Adenosine A1 receptor activation mediates the developmental shift at layer 5 pyramidal cell synapses and is a determinant of mature synaptic strength [PDF]

, 2013
During the first postnatal month glutamatergic synapses between layer 5 pyramidal cells in the rodent neocortex switch from an immature state exhibiting high probability of neurotransmitter release, large unitary amplitude and synaptic depression to a ...
Dunwiddie TV, Magnus J. E. Richardson, Mark J. Wall, Michael I. Kerr   +3 more
core   +1 more source

p32: A new player in autophagy [PDF]

Molecular & Cellular Oncology, 2016
Unc-51 like kinase-1 (Ulk1) is essential for autophagy induction. We recently reported that p32/C1QBP is crucial for the induction of autophagic flux upon starvation and the clearance of damaged mitochondria through the regulation of Ulk1 stability and kinase activity.
Haifeng, Jiao, Han, You
openaire   +2 more sources

The Many Faces of Talent Management: Organizational Perspectives on Talent and Talent Management Practices in Jordan

Human Resource Development Quarterly, EarlyView.
ABSTRACT Talent management involves the systematic planning, acquisition, development, performance management, engagement, and retention of employees identified as “talent.” Little is known about the relationship between organizations' talent perspectives and talent management practices.
Amro Aljbour, Erica French, Muhammad Ali
wiley   +1 more source

Between Emancipation and Domination? A Critical Analysis of Empowerment in a Women‐Only Development Program in Costa Rica's Coffee Sector

Sustainable Development, EarlyView.
ABSTRACT Female empowerment and its use in development contexts has histories in coloniality. Gender programs typically imply an individualistic, depoliticized concept. This article examines whether such initiatives can be supportive for empowerment. We apply an embedded qualitative case study of Bean Voyage's program to support female coffee producers
Annelie M. Gütte, Maria Busse, Stefan Sieber, Michelle Bonatti   +3 more
wiley   +1 more source

Dust in Spiral Galaxies: Comparing Emission and Absorption to Constrain Small-Scale and Very Cold Structures [PDF]

, 1999
The detailed distribution of dust in the disks of spiral galaxies is important to understanding the radiative transfer within disks, and to measuring overall dust masses if significant quantities of dust are either very opaque or very cold.
Alton P. B., Block D. L., Cesarsky C., Charmandaris V., Donovan L. Domingue, Elmegreen D. M., Haas M., Hildebrand R. H., Hummel E., Kessler M. F., Klaas U., Krugel E., Lagache G., Lemke D., Lloyd B. D., Raymond E. White III, Rowan-Robinson M., Siebenmorgen R., Stuart D. Ryder, Tuffs R. J., William C. Keel, Wozniak H.   +21 more
core   +2 more sources

A reappraisal of the Middle to Later Stone Age prehistory of Morocco Réévaluer la préhistoire du Maroc, du Middle Stone Age au Later Stone Age

Journal of the Royal Anthropological Institute, EarlyView.
Over the last 25 years, perceptions of the early prehistory of Northwest Africa have undergone radical changes due to new fieldwork projects and a corresponding growth in scientific interest in the region. Much of this work has been focused in Morocco, known for its extremely rich fossil and archaeological records in caves and rock shelters.
Nick Barton, Abdeljalil Bouzouggar, Stacy Carolin, Louise Humphrey   +3 more
wiley   +1 more source

The exceptional sets of a Waring-Goldbach problem with unequal powers

Xi'an Gongcheng Daxue xuebao, 2021
The representability of positive odd number n=p1+P32+p3k(k∈N and k≥4) was studied. The circle method in additive number theory and the iterative method in the circle method were used to deal with the main arcs and the exponential sum method was used to ...
Doudou ZHU
doaj   +1 more source

Theory of muonic hydrogen - muonic deuterium isotope shift

, 2004
We calculate the corrections of orders alpha^3, alpha^4 and alpha^5 to the Lamb shift of the 1S and 2S energy levels of muonic hydrogen (mu p) and muonic deuterium (mu d).
A. Adamczak, A. C. Zemach, A. Huber, A. I. Mil’shtein, A. P. Martynenko, A. P. Martynenko, A. P. Martynenko, A. P. Martynenko, A. P. Martynenko, E. Borie, E. E. Salpeter, E. H. Wichmann, E. V. Cherednikova, G. Breit, G. G. Simon, J. Bernabeu, J. L. Friar, J. L. Friar, J. R. Sapirstein, K. Pachucki, K. Pachucki, K. Pachucki, M. I. Eides, M. M. Sternheim, M. Niering, P. J. Mohr, R. Barbieri, R. N. Faustov, R. N. Faustov, R. Pohl, S. A. Zapryagaev, S. D. Drell, T. Kinoshita, V. B. Berestetskii, V. G. Ivanov, Yu. L. Sokolov   +35 more
core   +1 more source

Integrated Clinical Trial and Molecular Profiling Reveals Immune Drivers of Chronic Hand Eczema

Allergy, EarlyView.
This study performed an unbiased molecular profiling of CHE patients across diverse etiologies to identify shared pathogenic drivers and evaluate the impact of IL‐4Rα blockade via dupilumab over 16 weeks. CHE shows a mixed immune signature involving type 1, 2, and 3 pathways with features of atopic dermatitis and psoriasis.
Perrine Gery, Rüçhan Ekren, Emilie Bérard, Aurélie Du‐Thanh, Hugo Rimet, Fatma Jendoubi, Vanina Lenief, Nadia Raison‐Peyron, Amel Bouznad, Maria P. Konstantinou, Jonathan Rioual, Lilian Basso, Juliette Mouiren, Manon Boussier, Brigitte Milpied, Cristina Bulai Livideanu, Louise Jaulent, Florence Hacard, Marine A. Lefevre, Audrey Nosbaum, Julien Seneschal, Marc Vocanson, Carle Paul, Nicolas Gaudenzio, Marie Tauber, on behalf of the French Atopic Dermatitis Network from de GREAT Research group   +25 more
wiley   +1 more source