Results 251 to 260 of about 281,509 (352)

FGF7 mitigates airway inflammation and epithelial injury in cigarette smoke-induced COPD model. [PDF]

Front Immunol
Gong X, Li J, Wang H, Luo X, Hu X, Shen J, Jia W, Wan Q, Caikai S, Guo Z, Yan F, Zhang Y, Sun F, Xu S.   +13 more
europepmc   +1 more source

Osteoarthritis: An Immuno‐Inflammatory Disease‐Mechanisms of Immune Cell Dysregulation and Potential Therapeutic Strategies

Med Research, EarlyView.
This review summarizes the immuno‐inflammatory mechanisms driving the pathogenesis of osteoarthritis (OA), extending beyond the traditional view of OA as a purely degenerative disease to incorporate immune cell infiltration, inflammatory factor release, and the formation of a chronic low‐grade inflammatory microenvironment.
Qingqiang Lei, Xiaoxian Lou, Xu Su, Shubao Liu, Yanli Tong, Jie Chen, Xuerui Chen, Wenjun Mao, Hui Yu, Liangbin Lin   +9 more
wiley   +1 more source

Apoptosis as an evolutionary battleground: pathogen pressure and the shaping of programmed cell death pathways. [PDF]

Front Cell Dev Biol
Román-Carraro FC, Gutiérrez-Kobeh L.
europepmc   +1 more source

Recent Advances in Exosome‐Based Nanodelivery Systems for Traumatic Brain Injury Treatment

Med Research, EarlyView.
An overview of functional modification, therapeutic effects, molecular composition, and delivery strategies for exosomes. ABSTRACT Traumatic brain injury (TBI) is a highly heterogeneous neurological condition with extremely high rates of mortality and disability.
Jue Zhu, Weiquan Liao, Ziqi Lian, Mengdan Zhang, Chenxing Wang, Xingjia Zhu, Lin Zhang, Jian Chen, Zhichao Lu, Peipei Gong   +9 more
wiley   +1 more source

AMPK/p38 MAPK signaling selectively enhances HIF-induced VEGF-A165 expression under hypoxic and low-glucose conditions in HepG2 cells to promote endothelial cell proliferation and migration. [PDF]

BMC Cancer
Hashinokuchi H, Yamakuchi M, Higashi S, Takenouchi K, Tabaru A, Oyama Y, Fujisaki C, Tanoue K, Okawa M, Namino F, Hashiguchi T.   +10 more
europepmc   +1 more source

Organoid Coculture Models for Cancer Research and Immunotherapy

Med Research, EarlyView.
This review summarizes organoid coculture platforms, including submerged Matrigel culture, air–liquid interface, microfluidic/organoid‐on‐a‐chip, and 3D bioprinting, for reconstructing the tumor microenvironment to study tumor–stroma/immune crosstalk, evaluate immunotherapies, and enable drug screening.
Zhuo Yang, Huihui Yang, Guangxin Li, Guobang Liu, Zhulan Chen, Wenzhi Tian, Meiyang Huang, Xiaoling Liu, Yongsheng Zhao, Dong Chen   +9 more
wiley   +1 more source

Platelet Drp1 phosphorylation provides a platform for immune-based platelet function testing. [PDF]

Blood
Barrios DA, Guo S, Powers M, Koseoglu S, Zerbey S, Lu R, Cermak A, Vayne C, Khan S, Aisiku O, Urman A, Thomas J, Patell R, Zwicker JI, Flaumenhaft R.   +14 more
europepmc   +1 more source

Small‐Molecule Kinase Inhibitors Modulating Circadian Rhythms

Medicinal Research Reviews, EarlyView.
ABSTRACT The circadian clock mechanism generates 24‐h rhythms crucial for regulating various physiological processes, and its dysregulation has been implicated in numerous diseases. In cells, the circadian clock operates through a transcriptional‐translational feedback loop, where phosphorylation plays a pivotal role in maintaining accurate circadian ...
Irene Castellino, Manuela Bartolini, Rudolf Andrys, Kamil Musilek   +3 more
wiley   +1 more source

Statement of Retraction: Nesfatin-1 protects against diabetic cardiomyopathy in the streptozotocin-induced diabetic mouse model via the p38-MAPK pathway. [PDF]

Bioengineered
europepmc   +1 more source

AGTRAP mediates exosome-driven communication between cancer cells and macrophages via p38 MAPK pathway to promote hepatocellular carcinoma. [PDF]

BBA Adv
Liu S, Li Z, Liu H, Chen X, Liu Y, Tang J, Chen Y, Zeng D.   +7 more
europepmc   +1 more source