Results 271 to 280 of about 205,636 (290)
MiR-27a-3p Enhances Endometrial Cancer Growth and EMT by Targeting LIFR and Activating the p38/MAPK Pathways. [PDF]
Iran J BiotechnolHu Q, Chen X.
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Protective effects of Shenkang injection against diabetic kidney disease via p38 MAPK/NFκB/MCP-1/CCR2 pathway inhibition. [PDF]
Front Endocrinol (Lausanne)Zhou X +5 more
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p38 MAPK regulates COPII recruitment
Biochemical and Biophysical Research Communications, 2007Here, we investigate regulation of coat protein complex II (COPII) recruitment onto ER export sites in permeabilized cells. In cytosols from nocodazole treated HeLa cells we find COPII loading is inhibited. The stress kinase p38 MAPK is activated in these cytosols and COPII loading can be rescued by depletion of p38 MAPK alpha or by the p38 MAPK ...
Wang, Lijun, Lucocq, John M.
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Pyridazine based inhibitors of p38 MAPK
Bioorganic & Medicinal Chemistry Letters, 2002Trisubstituted pyridazines were synthesized and evaluated as in vitro inhibitors of p38MAPK. The most active isomers were those possessing an aryl group alpha and a heteroaryl group beta relative to the nitrogen atom in the 2-position of the central pyridazine.
Charles J, McIntyre +7 more
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2007
There are four members of the mammalian p38 mitogen-activated protein kinases (MAPKs) family (p38α, p38β, p38γ and p38δ) which are about 60% identical in their amino acid sequence but differ in their expression patterns, substrate specificities, and sensitivities to chemical inhibitors such as SB203580.
Francisco Iñesta-Vaquera +3 more
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There are four members of the mammalian p38 mitogen-activated protein kinases (MAPKs) family (p38α, p38β, p38γ and p38δ) which are about 60% identical in their amino acid sequence but differ in their expression patterns, substrate specificities, and sensitivities to chemical inhibitors such as SB203580.
Francisco Iñesta-Vaquera +3 more
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Impact of curcumin on p38 MAPK: therapeutic implications
Inflammopharmacology, 2023Curcumin (diferuloylmethane) is a herbal remedy which possesses numerous biological attributes including anti-inflammatory, anti-oxidant and anti-cancer properties. Curcumin has been shown to impact a number of signaling pathways including nuclear factor kappa B (NF-KB), reactive oxygen species (ROS), Wingless/Integrated (Wnt), Janus kinase-signal ...
Hedieh Sadat Shamsnia +9 more
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p38 MAPK signalling cascades in inflammatory disease
Molecular Medicine Today, 1999Inflammatory mediators released during acute and chronic diseases activate multiple intracellular signalling cascades including the mitogen-activated protein kinase (MAPK) signal transduction pathway, which plays a significant role in the recruitment of leukocytes to sites of inflammation.
E, Herlaar, Z, Brown
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Mechanisms and functions of p38 MAPK signalling
Biochemical Journal, 2010The p38 MAPK (mitogen-activated protein kinase) signalling pathway allows cells to interpret a wide range of external signals and respond appropriately by generating a plethora of different biological effects. The diversity and specificity in cellular outcomes is achieved with an apparently simple linear architecture of the pathway, consisting of a ...
Cuadrado, Ana, Nebreda, Angel R.
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p38 MAPK Signaling in Oral-related Diseases
Journal of Dental Research, 2007Multiple dental diseases are characterized by chronic inflammation, due to the production of cytokines, chemokines, and prostanoids by immune and non-immune cells. Membrane-bound receptors provide a link between the extracellular environment and the initiation of intracellular signaling events that activate common signaling components, including p38 ...
C S, Patil, K L, Kirkwood
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