Results 261 to 270 of about 229,819 (298)
A Peroxiredoxin-P38 MAPK Scaffold Increases MAPK Activity by MAP3K-Independent Mechanisms [PDF]
Molecular Cell, 2023 Peroxiredoxins (Prdxs) utilize reversibly oxidized cysteine residues to reduce peroxides and promote H2O2 signal transduction, including H2O2-induced activation of P38 MAPK.
Brian A Morgan +2 more
exaly +7 more sources
Involvement of p38 MAPK in Synaptic Function and Dysfunction [PDF]
International Journal of Molecular Sciences, 2020 Many studies have revealed a central role of p38 MAPK in neuronal plasticity and the regulation of long-term changes in synaptic efficacy, such as long-term potentiation (LTP) and long-term depression (LTD). However, p38 MAPK is classically known as a responsive element to stress stimuli, including neuroinflammation.
Ottavio Arancio +2 more
exaly +5 more sources
The Role of p38 MAPK in the Development of Diabetic Cardiomyopathy [PDF]
International Journal of Molecular Sciences, 2016 Diabetic cardiomyopathy (DCM) is a major complication of diabetes that contributes to an increase in mortality. A number of mechanisms potentially explain the development of DCM including oxidative stress, inflammation and extracellular fibrosis. Mitogen-activated protein kinase (MAPK)-mediated signaling pathways are common among these pathogenic ...
Shudong Wang
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Inactivation of p38 MAPK During Liver Regeneration [PDF]
International Journal of Biochemistry and Cell Biology, 2011 There is increasing evidence that p38 MAPK, which is classified as a stress-activated kinase, also participates in cell cycle regulation, functioning as a suppressor of cell proliferation and tumorigenesis. We conducted a study of p38 MAPK phosphorylation during liver regeneration in mice to determine whether p38 MAPK activation or inactivation may ...
Brian Hayes +2 more
exaly +3 more sources
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Mechanisms and functions of p38 MAPK signalling
Biochemical Journal, 2010The p38 MAPK (mitogen-activated protein kinase) signalling pathway allows cells to interpret a wide range of external signals and respond appropriately by generating a plethora of different biological effects. The diversity and specificity in cellular outcomes is achieved with an apparently simple linear architecture of the pathway, consisting of a ...
Cuadrado, Ana, Nebreda, Angel R.
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Roles of p38 MAPKs in invasion and metastasis
Biochemical Society Transactions, 2012Cells from primary tumours need to go through several steps to become fully metastatic. During this process, cancer cells acquire the ability to invade, migrate across the surrounding tissue, enter into the circulation and colonize distant organs. In the present paper, we review recent progress in understanding how the p38 MAPK (mitogen-activated ...
Barrantes, Ivan Del Barco +1 more
openaire +2 more sources
Pyridazine based inhibitors of p38 MAPK
Bioorganic & Medicinal Chemistry Letters, 2002Trisubstituted pyridazines were synthesized and evaluated as in vitro inhibitors of p38MAPK. The most active isomers were those possessing an aryl group alpha and a heteroaryl group beta relative to the nitrogen atom in the 2-position of the central pyridazine.
Charles J, McIntyre +7 more
openaire +2 more sources
Impact of curcumin on p38 MAPK: therapeutic implications
Inflammopharmacology, 2023Curcumin (diferuloylmethane) is a herbal remedy which possesses numerous biological attributes including anti-inflammatory, anti-oxidant and anti-cancer properties. Curcumin has been shown to impact a number of signaling pathways including nuclear factor kappa B (NF-KB), reactive oxygen species (ROS), Wingless/Integrated (Wnt), Janus kinase-signal ...
Hedieh Sadat Shamsnia +9 more
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p38 MAPK Signalling Cascades in Inflammatory Disease
Trends in Molecular Medicine, 1999Inflammatory mediators released during acute and chronic diseases activate multiple intracellular signalling cascades including the mitogen-activated protein kinase (MAPK) signal transduction pathway, which plays a significant role in the recruitment of leukocytes to sites of inflammation.
E, Herlaar, Z, Brown
exaly +3 more sources
2007
There are four members of the mammalian p38 mitogen-activated protein kinases (MAPKs) family (p38α, p38β, p38γ and p38δ) which are about 60% identical in their amino acid sequence but differ in their expression patterns, substrate specificities, and sensitivities to chemical inhibitors such as SB203580.
Francisco Iñesta-Vaquera +3 more
openaire +1 more source
There are four members of the mammalian p38 mitogen-activated protein kinases (MAPKs) family (p38α, p38β, p38γ and p38δ) which are about 60% identical in their amino acid sequence but differ in their expression patterns, substrate specificities, and sensitivities to chemical inhibitors such as SB203580.
Francisco Iñesta-Vaquera +3 more
openaire +1 more source