Results 111 to 120 of about 84,309 (251)

Trpv4 Activation Aggravates Temporomandibular Joint Osteoarthritis Via P38 Mapk Pathway

International Dental Journal
Aim or purpose: This study aimed to explore the underlying mechanisms after transient receptor potential vanilloid 4 (TRPV4) activation in disc during the progress of temporomandibular joint osteoarthritis (TMJOA).
Xiaotong Yu, Fu-Jia Yang, Yan Gu, Sheng-Jie Cui   +3 more
doaj   +1 more source

Chemical Knockdown of Phosphorylated p38 Mitogen-Activated Protein Kinase (MAPK) as a Novel Approach for the Treatment of Alzheimer's Disease. [PDF]

ACS Cent Sci, 2023
Son SH, Lee NR, Gee MS, Song CW, Lee SJ, Lee SK, Lee Y, Kim HJ, Lee JK, Inn KS, Kim NJ.   +10 more
europepmc   +1 more source

CD36‐mediated lipid rewiring in the metabolic adaptation of tumour ecosystems

The FEBS Journal, EarlyView.
Nutrient deprivation drives a lipid‐centric shift in tumour metabolic symbiosis and signalling network. CD36 functions as a bidirectional bridge, transferring fatty acids from stromal donors (adipocytes, CAFs) to the ecosystem tumour‐ and microenvironment‐dependently.
Anna Sebestyén, Viktória Varga, Fatime Szalai, Risa Miyaura, Nóra Förhécz, Bálint Csikós, Rebeka Gelencsér, Zsófia Gábriel, Timea Komlódi, Katalin Dezső, Ildikó Krencz, Dorottya Moldvai   +11 more
wiley   +1 more source

[Retracted] Glycyrrhizin protects mice against renal ischemia‑reperfusion injury through inhibition of apoptosis and inflammation by downregulating p38 mitogen‑activated protein kinase signaling. [PDF]

Exp Ther Med, 2023
Ye S, Zhu Y, Ming Y, She X, Liu H, Ye Q.
europepmc   +1 more source

Protective effects of extracellular vesicle‐like nanoparticles derived from Cannabis sativa adventitious roots against UVB‐induced damage in human keratinocytes

International Journal of Cosmetic Science, EarlyView.
Cannabis sativa root‐derived extracellular vesicle‐like nanoparticles (CA‐NPs) were isolated from adventitious root cultures and subjected to physicochemical characterization. Upon UVB exposure, keratinocytes exhibited increased ROS generation, apoptosis and MAPK activation, leading to oxidative stress and skin damage.
Dong Ho Bak, Su Hyun Park, Young Bae Ryu, Cha Young Kim, Jae Cheol Jeong, Woo Sik Kim   +5 more
wiley   +1 more source

Effect of the p38 Mitogen-Activated Protein Kinase Signaling Cascade on Radiation Biodosimetry. [PDF]

Radiat Res, 2022
Broustas CG, Mukherjee S, Pannkuk EL, Laiakis EC, Fornace AJ, Amundson SA.   +5 more
europepmc   +1 more source

Malaria mosquito antimicrobial defence requires immunity and detoxification gene regulation by Lola

Insect Molecular Biology, EarlyView.
Malaria mosquito antimicrobial defence requires upregulation of lola. Attenuation of lola in the midgut of Anopheles albimanus mosquitoes inhibits the upregulation of immunity genes induced by challenge. Putative target genes of the Lola transcription factor were revealed by lola attenuation, including Cecropin‐C, Draper, PPAF2, Clip‐domain serine ...
Heidi Espadas‐Álvarez, Verónica Valverde‐Garduño   +1 more
wiley   +1 more source

Correction: Carbon monoxide inhibition of apoptosis during ischemia-reperfusion lung injury is dependent on the p38 mitogen-activated protein kinase pathway and involves caspase 3. [PDF]

J Biol Chem, 2023
Zhang X, Shan P, Otterbein LE, Alam J, Flavell RA, Davis RJ, Choi AMK, Lee PJ.   +7 more
europepmc   +1 more source

MyD88‐Family Adaptors: Compartmentalised Signalling and Non‐Immune Functions

Immunology, EarlyView.
MyD88‐family adaptors coordinate receptor‐ and compartment‐specific innate immune signalling across plasma membrane and endosomal pathways. At the plasma membrane, TIRAP/MAL supports MyD88‐dependent signalling downstream of TLR2 and TLR4, whereas endosomal TLR7, TLR8 and TLR9 recruit MyD88 directly.
Seshu Vardhan Pothabathula, Saurabh Mishra, Pugazhendhi Kannan, Annette Bellar, Amy Attaway, Nicole Welch, Srinivasan Dasarathy   +6 more
wiley   +1 more source

Mechanism of polysaccharide from Arthrospira platensis in regulating inflammatory response induced by porcine pseudorabies virus in porcine alveolar macrophages

Siliao yanjiu
This study aimed to investigate the regulatory effect and mechanism of polysaccharide component 1 from Arthrospira platensis (PAP-1) on the inflammatory response induced by porcine pseudorabies virus (PRV) in porcine alveolar macrophages cells (3D4/2 ...
YUAN Haifeng, HOU Zongyuan, WANG Yaqi, LIANG Huangming, HU Tingjun   +4 more
doaj