Results 91 to 100 of about 4,528,027 (196)

Oxidative Stress-Induced Diseases via the ASK1 Signaling Pathway

International Journal of Cell Biology, 2012
Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase (MAPK) kinase kinase that activates the downstream MAPKs, c-Jun N-terminal kinase (JNK) and p38.
Mayumi Soga, Atsushi Matsuzawa, Hidenori Ichijo   +2 more
doaj   +1 more source

Inhibitors of p38 mitogen-activated protein kinase

, 2012
Asthma is an inflammatory disease of the airways, which in patients with mild to moderate symptoms is adequately controlled by either beta(2)-adrenoceptor agonists or corticosteroids, or a combination of both. Despite this, there are classes of patients that fail to respond to these treatments.
Robert Newton, Neil Holden
openaire   +1 more source

The p38 mitogen-activated protein kinase critically regulates human keratinocyte inflammasome activation

, 2018
Inflammasomes are key intracellular signaling platforms involved in innate immune responses to micro-organisms and danger signals. Extracellular signal-regulated kinase, Jun N-terminal kinase, and p38 mitogen-activated protein kinase family members are ...
Grossi, Serena, Fenini, Gabriele; https://orcid.org/, Gehrke, Samuel, Hans-Dietmar Beer, Serena Grossi, French, Lars E, Samuel Gehrke, Beer, Hans-Dietmar; https://orcid.org/, Emmanuel Contassot, Contassot, Emmanuel, Gabriele Fenini, Satoh, Takashi K, Lars E. French, Takashi K. Satoh, Satoh TK, Fenini G, Gehrke S, Beer HD, Grossi S, French LE, Contassot E   +20 more
core   +1 more source

The development of AZD7624 for prevention of exacerbations in COPD: a randomized controlled trial

International Journal of COPD, 2018
Naimish R Patel,1,2 Danen M Cunoosamy,1 Malin Fagerås,1 Ziad Taib,1 Sara Asimus,1 Tove Hegelund-Myrbäck,1 Sofia Lundin,1 Katerina Pardali,1 Nisha Kurian,1 Eva Ersdal,1 Cecilia Kristensson,1 Katarina Korsback,1 Robert Palmér,1 Mary N ...
Patel NR, Cunoosamy DM, Fagerås M, Taib Z, Asimus S, Hegelund-Myrbäck T, Lundin S, Pardali K, Kurian N, Ersdal E, Kristensson C, Korsback K, Palmér R, Brown MN, Greenaway S, Siew L, Clarke GW, Rennard SI, Make BJ, Wise RA, Jansson P   +20 more
doaj  

Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6

, 2008
The cellular response to treatment with proinflammatory cytokines or exposure to environmental stress is mediated, in part, by the p38 group of mitogen-activated protein (MAP) kinases. We report the molecular cloning of a novel isoform of p38 MAP kinase,
Davis, Roger J., Enslen, Herve, Raingeaud, Joel   +2 more
core   +1 more source

p38 Mitogen-Activated Protein Kinase Inhibition of Mesenchymal Transdifferentiated Tumor Cells in Head and Neck Squamous Cell Carcinoma. [PDF]

Biomedicines, 2023
Federspiel J, Greier MDC, Ladányi A, Dudas J.   +3 more
europepmc   +1 more source

Stimulation of glucose transport by AMP-activated protein kinase via activation of p38 mitogen-activated protein kinase

, 2001
Activation of AMP-activated protein kinase (AMPK) has been recently demonstrated to be associated with 5-aminoimidazole-4-carboxa;de ribonucleoside (AICAR)stimulated glucose transport mediated by both GLUT1 and GLUT4 transporters.
韩家淮, Han, J. H., Zhang, J. Z., Xi, X.   +3 more
core  

Post-transcriptional regulation of gene expression by mitogen-activated protein kinase p38.

, 2003
The mitogen-activated protein kinase p38 pathway was originally identified as a signalling cascade activated by pro-inflammatory stimuli and cellular stresses, and playing a critical role in the translational regulation of pro-inflammatory cytokine ...
Saklatvala, Jeremy, Andrew R. Clark, Clark, Andrew R., Jeremy Saklatvala, Jonathan L.E. Dean, Dean, Jonathan L.E.   +5 more
core   +1 more source

p38 mitogen-activated protein kinase (p38 MAPK; MAPK14) [PDF]

Science-Business eXchange, 2014
openaire   +2 more sources

Design, synthesis, and study of novel phenethyl-based antitumor phospholipids downregulating p38 mitogen-activated protein kinase. [PDF]

J Enzyme Inhib Med Chem, 2023
Hassan AHE, Oh YI, Lee CH, Kim YJ, Cho SB, Alam MM, Park SE, Chung KS, Lee KT, Lee YS.   +9 more
europepmc   +1 more source