Results 221 to 230 of about 84,309 (251)

p38 Mitogen-Activated Protein Kinase Pathways in Asthma and COPD

Chest, 2011
The mitogen-activated protein kinase (MAPK) family includes the p38 kinases, which consist of highly conserved proline-directed serine-threonine protein kinases that are activated in response to inflammatory signals. Of the four isoforms, p38α is the most abundant in inflammatory cells and has been the most studied through mainly the availability of ...
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Dehydroepiandrosterone negatively regulates the p38 mitogen-activated protein kinase pathway by a novel mitogen-activated protein kinase phosphatase

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 2005
Dehydroepiandrosterone-sulfate, the sulfated form of dehydroepiandrosterone, is the most abundant steroid in young adults, but gradually declines with aging. In humans, the clinical application of dehydroepiandrosterone targeting some collagen diseases, such as systemic lupus erythematosus, as an adjunctive treatment has been applied in clinical trial.
Kenji, Ashida, Kiminobu, Goto, Yue, Zhao, Taijiro, Okabe, Toshihiko, Yanase, Ryoichi, Takayanagi, Masatoshi, Nomura, Hajime, Nawata   +7 more
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Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK, and p38 Protein Kinases

Science, 2002
Multicellular organisms have three well-characterized subfamilies of mitogen-activated protein kinases (MAPKs) that control a vast array of physiological processes. These enzymes are regulated by a characteristic phosphorelay system in which a series of three protein kinases phosphorylate and activate one another.
Gary L, Johnson, Razvan, Lapadat
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Role of p38 mitogen-activated protein kinase in posttraumatic immunosuppression in mice

Journal of Trauma and Acute Care Surgery, 2012
Patients with multiple injuries surviving the initial insult are highly susceptible to secondary pneumonia, frequently progressing into sepsis and multiorgan failure. However, the underlying mechanisms of posttraumatic immunosuppression are poorly understood.
Nadine, Ding, Katja, Dahlke, Ann-Kathrin, Janze, Petra C, Mailer, Regina, Maus, Jennifer, Bohling, Tobias, Welte, Michael, Bauer, Niels C, Riedemann, Ulrich A, Maus   +9 more
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p38 Mitogen-Activated Protein Kinase Inhibitors— Mechanisms and Therapeutic Potentials

Pharmacology & Therapeutics, 1999
The pyridinylimidazole compounds, exemplified by SB 203580, originally were prepared as inflammatory cytokine synthesis inhibitors. Subsequently, the compounds were found to be selective inhibitors for p38 mitogen-activated protein kinase (MAPK), a member of the MAPK family.
J C, Lee, S, Kassis, S, Kumar, A, Badger, J L, Adams   +4 more
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Activation of p38 Mitogen-activated Protein Kinase in Rat Periapical Lesions

Journal of Endodontics, 2008
The purpose of this study was to investigate the activation of p38 mitogen-activated protein kinase (MAPK) during the development of periapical lesions in rats. Periapical lesions developed within 28 days after pulp exposure of mandibular first molars in Wistar rats.
Rui, Zhang, Li, Wang, Bin, Peng
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Mitogen-Activated Protein Kinase p38 Pathway in Venous Ulcer Fibroblasts

Vascular and Endovascular Surgery, 2008
Objective: Venous ulcer fibroblasts (w-fb) have attenuated growth compared to normal fibroblasts (n-fb). The MAPKp38 pathway mediates stress-responses in various diseases. We hypothesize that p38 pathway is altered in w-fb. Methods: W-fb were isolated from venous ulcers and n-fb from the ipsilateral thigh.
Joseph D, Raffetto, Christopher H, Gram, Kristen C, Overman, James O, Menzoian   +3 more
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Structure-Activity Relationships of p38 Mitogen-Activated Protein Kinase Inhibitors

Mini-Reviews in Medicinal Chemistry, 2005
Rheumatoid arthritis and other chronic inflammatory diseases constitute a major therapeutic challenge, usually not sufficiently met by the classical antiinflammatory medications. Recent research efforts provided new insights into the molecular basis of these pathologies and disclosed new opportunities for developing improved drugs directed to the ...
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p38 Mitogen Activated Protein Kinase as a Therapeutic Target for Alzheimer's Disease

Journal of Molecular Neuroscience, 2002
The characteristic pathological hallmarks of Alzheimer's disease (AD) include neuritic plaques, neurofibrillary tangles, and inflammatory changes. Current therapies, such as molecules that target enhancing cholinergic activity, can improve cognitive function in the short term but, unfortunately, have no impact on progression of the disease.
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Assays for JNK and p38 Mitogen-Activated Protein Kinases

2000
T, Sudo, M, Karin
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