Results 211 to 220 of about 84,309 (251)

Toll Like Receptor 4: A Potential Link Between Obesity and Metabolic Diseases

Obesity Reviews, Volume 27, Issue 8, August 2026.
ABSTRACT Epidemiological evidence shows that obesity increases the risk of developing metabolic diseases. Nevertheless, the mechanisms behind this connection remain underappreciated. The substantial impact of these disorders on global health has led to extensive research efforts aimed at identifying the pathophysiological links between them.
Ghadeer Alhamar, Joanna Razafiarison, Fawaz Alzaid, Fahd Al‐Mulla, Rasheed Ahmad   +4 more
wiley   +1 more source

Immunomodulatory Potential of Quinoline Q3, a Selective Inhibitor of the Canonical NF‐κB Pathway in Macrophages

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
The quinolone Q3 specifically enhances the DNA binding of the p50/p50 NF‐κB dimers, while inhibiting the activity of the p65 transcriptional activator, resulting in inhibition of the NF‐κB canonical pathway in lipopolysaccharide (LPS)‐stimulated macrophages.
Konstantinos Michail, Panagiotis Ntavaroukas, Vasiliki Petriki, Evangelos Tsioupros, Stella Manta, Barry J. Campbell, Stamatia Papoutsopoulou   +6 more
wiley   +1 more source

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Role of p38 Mitogen-Activated Protein Kinase in Thrombus Formation

Journal of Receptor and Signal Transduction Research, 2004
The present study was designed to elucidate the role of p38 mitogen-activated protein kinase (p38) in thrombus formation. We used p38alpha heterozygous (p38alpha+/-) mice and used ferric chloride (FeCl3)-induced carotid artery injury as a model of thrombus formation.
Yoh Takuwa, Sadao Kimura, Yoshitoshi Kasuya   +2 more
exaly   +3 more sources

Current Insights of Inhibitors of p38 Mitogen-Activated Protein Kinase in Inflammation

Medicinal Chemistry, 2021
Background:: Inflammatory process is one of the mechanisms by which our body upholds us from pathogens such as parasites, bacteria, viruses, and other harmful microorganisms. Inflammatory stimuli activate many intracellular signaling pathways such as nuclear factor-kB (NF-kB) pathway and three mitogen-activated protein kinase (MAPK) pathways which ...
Md Azizur Rahman
exaly   +3 more sources

p38 mitogen-activated protein kinase and pain

Life Sciences, 2020
Inflammatory and neuropathic pain is initiated by tissue inflammation and nerve injury, respectively. Both are characterized by increased activity in the peripheral and central nervous system, where multiple inflammatory cytokines and other active molecules activate different signaling pathways that involve in the development and/or maintenance of pain.
Lijia, Mai, Xiao, Zhu, Fang, Huang, Hongwen, He, Wenguo, Fan   +4 more
openaire   +2 more sources

p38 Mitogen-Activated Protein Kinase Regulates Myelination

Journal of Molecular Neuroscience, 2007
The p38 mitogen-activated protein kinase family is emerging as a crucial signaling molecule for a vast number of cellular functions including cell migration, proliferation, and differentiation. The function of p38 in myelination has only been recently addressed.
Jeffery D, Haines, Gabriela, Fragoso, Shireen, Hossain, Walter E, Mushynski, Guillermina, Almazan   +4 more
openaire   +2 more sources

p38 Mitogen-Activated Protein Kinase (MAPK) in Rheumatoid Arthritis

Mini-Reviews in Medicinal Chemistry, 2006
The importance of p38 MAPK inhibitors as new drug for rheumatoid arthritis is reflected by the large number of compounds that has been developed over the last years. In this review new insights such as non-stressful activation of p38 MAPK, and the role of p38 MAPK in regulation of NF-kappaB recruitment are also discussed.
J, Westra, P C, Limburg
openaire   +2 more sources

Analyzing JNK and p38 mitogen-activated protein kinase activity

2001
Publisher Summary The JNK and p38 mitogen-activated protein (MAP) kinase groups are important for many physiological processes including cell growth, oncogenic transformation, cell differentiation, apoptosis, and the immune response. To understand the role of JNK and p38 MAP kinases in the cell, several protocols for measuring their activation state ...
Whitmarsh, A. J., Davis, R. J.
openaire   +3 more sources

Inhibitors of p38 Mitogen-Activated Protein Kinase

BioDrugs, 2003
Asthma is an inflammatory disease of the airways, which in patients with mild to moderate symptoms is adequately controlled by either beta(2)-adrenoceptor agonists or corticosteroids, or a combination of both. Despite this, there are classes of patients that fail to respond to these treatments.
Robert, Newton, Neil, Holden
openaire   +2 more sources