Results 111 to 120 of about 177,903 (366)

Innovative PDK1‐Degrading PROTACs Transform Cancer Aerobic Glycolysis and Induce Immunogenic Cell Death in Breast Cancer

Exploration, EarlyView.
In this study, A04, a compound targeting the degradation of metabolic enzyme PDK1, was developed by PROTAC technology, which significantly inhibited tumor proliferation by disrupting the Warburg effect in cancer cells. In the mouse model, A04 could prolong postoperative survival, and also remodel the immunosuppressive microenvironment, which could ...
Aohua Deng, Renming Fan, Jiakui Gou, Ruoxi Sang, Ruizhuo Lin, Ting Zhao, Junyan Zhuang, Yongrui Hai, Jialin Sun, Gaofei Wei   +9 more
wiley   +1 more source

The role of stress-activated protein kinase signaling in renal pathophysiology

Brazilian Journal of Medical and Biological Research, 2009
Two major stress-activated protein kinases are the p38 mitogen-activated protein kinase (MAPK) and the c-Jun amino terminal kinase (JNK). p38 and JNK are widely expressed in different cell types in various tissues and can be activated by a diverse range ...
F.Y. Ma, J. Liu, D.J. Nikolic-Paterson
doaj  

Thrombin Protease-activated Receptor-1 Signals through Gq- and G13-initiated MAPK Cascades Regulating c-Jun Expression to Induce Cell Transformation [PDF]

, 2003
Although the ability of G protein-coupled receptors to stimulate normal and aberrant cell growth has been intensely investigated, the precise nature of the molecular mechanisms underlying their transforming potential are still not fully understood.
Gutkind, J. Silvio, Marinissen, Maria Julia, Offermanns, Stefan, Servitja, Joan-Marc, Simon, Melvin I.   +4 more
core   +1 more source

Spatial Transcriptomic Analysis Reveals HDAC Inhibition Modulates Microglial Dynamics to Protect Against Ischemic Stroke in Mice

Glia, EarlyView.
Spatial transcriptomic analysis unravels the mechanisms by which HDACi ameliorates neuroinflammation and enhances neuroprotection by modulating the expression of microglial transcriptomes in the ischemic mouse brain. ABSTRACT Ischemic stroke significantly contributes to global morbidity and disability through a cascade of neurological responses ...
Kevin Jayaraj, Ritesh Kumar, Sukanya Shyamasundar, Thiruma V. Arumugam, Jai S. Polepalli, S. Thameem Dheen   +5 more
wiley   +1 more source

The inhibitory mechanism of crude saponin fraction from Korean Red Ginseng in collagen-induced platelet aggregation

Journal of Ginseng Research, 2015
Background: Korean Red Ginseng has been used as a traditional oriental medicine to treat illness and to promote health for several thousand years in Eastern Asia. It is widely accepted that ginseng saponins, ginsenosides, are the major active ingredients
Bo Ra Jeon, Su Jung Kim, Seung Bok Hong, Hwa-Jin Park, Jae Youl Cho, Man Hee Rhee   +5 more
doaj   +1 more source

Fatigue Resistance and Mitochondrial Adaptations to Isometric Interval Training in Dystrophin-Deficient Muscle: Role of Contractile Load. [PDF]

FASEB J
High‐load, but not low‐load, isometric interval training (IT) increased mitochondrial content and muscle fatigue resistance in mdx52 mice, a model for Duchenne muscular dystrophy. High‐load isometric IT restored citrate synthase activity, peroxisome proliferator‐activated receptor γ coactivator 1 alpha (PGC‐1α) expression, and mitochondrial complex II ...
Yamauchi N, Ashida Y, Naito A, Tokuda N, Niibori A, Motohashi N, Aoki Y, Yamada T.   +7 more
europepmc   +2 more sources

Roles of Mitogen-Activated Protein Kinases in Osteoclast Biology

International Journal of Molecular Sciences, 2018
Bone undergoes continuous remodeling, which is homeostatically regulated by concerted communication between bone-forming osteoblasts and bone-degrading osteoclasts.
Kyunghee Lee, Incheol Seo, M. Choi, Daewon Jeong   +3 more
semanticscholar   +1 more source

Effect of p38 Mitogen-Activated Protein Kinase on the Replication of Encephalomyocarditis Virus [PDF]

Journal of Virology, 2003
ABSTRACTCellular phosphorylation events during viral infection are necessary for effective viral replication. Encephalomyocarditis (EMC) virus has been used for studies on the molecular mechanisms of viral replication, but little is known about the cellular signaling pathways involved.
Angus Kim, K. Hirasawa, Hye-Seung Han, Ji-Won Yoon, Jaeseok Han, Hee-Sook Jun   +5 more
openaire   +3 more sources

A p38MAPK/MK2 signaling pathway leading to redox stress, cell death and ischemia/reperfusion injury [PDF]

, 2014
Background Many diseases and pathological conditions are characterized by transient or constitutive overproduction of reactive oxygen species (ROS).
Ashraf, Muhammad Imtiaz, Brandacher, Gerald, Dragun, Duska, Ebner, Matthias, Enthammer, Marion, Haller, Martina, Hermann, Martin, Khalid, Sana, Koziel, Katarzyna, Santer, Peter, Schwelberger, Hubert, Sickinger, Stephan, Soleiman, Afschin, Steger, Christina, Sucher, Robert, Troppmair, Jakob, Vallant, Stephanie, Wallner, Christoph   +17 more
core   +2 more sources

Activation of the p38 Mitogen-activated Protein Kinase by Type I Interferons [PDF]

Journal of Biological Chemistry, 1999
The p38 mitogen-activated protein (Map) kinase plays a critical role in the generation of signals in response to stress stimuli, but its role in interferon (IFN) signaling and its potential regulatory role in the activation of Jak-signal transducer and activator of transcription (Stat) pathway are not known.
Leonidas C. Platanias, Yazan Alsayed, Pony Arunkumar, Beata Majchrzak, Eleanor N. Fish, Peter R. Young, Joanna Woodson, Shahab Uddin, Richard Pine   +8 more
openaire   +3 more sources