Results 111 to 120 of about 183,974 (371)

Receptor for advanced glycation end products aggravates cognitive deficits in type 2 diabetes through binding of C‐terminal AAs 2‐5 to mitogen‐activated protein kinase kinase 3 (MKK3) and facilitation of MEKK3‐MKK3‐p38 module assembly [PDF]

, 2022
Xiaoyan Zhou, Changjiang Ying, Bin Hu, Yusheng Zhang, Tian Gan, Yandong Zhu, Nan Wang, An‐An Li, Yuanjian Song   +8 more
openalex   +1 more source

Roles of Mitogen-Activated Protein Kinases in Osteoclast Biology

International Journal of Molecular Sciences, 2018
Bone undergoes continuous remodeling, which is homeostatically regulated by concerted communication between bone-forming osteoblasts and bone-degrading osteoclasts.
Kyunghee Lee, Incheol Seo, M. Choi, Daewon Jeong   +3 more
semanticscholar   +1 more source

Rutaceae Zanthoxylum–Derived 7‐Demethylsuberosin Alleviates the Rheumatoid Arthritis Through Inhibiting the Maturation of Dendritic Cells via Targeting MAPK14 Functional Food‐Based 7‐Demethylsuberosin

Food Frontiers, EarlyView.
This study revealed that 7‐demethylsuberosin exhibits immunosuppressive effects both in vivo and in vitro. Furthermore, it inhibits the phosphorylation of MAPK14 by targeting it, thereby modulating dendritic cell (DC) maturation and function and reducing inflammation across various in vivo models.
Peng Han, Bo Wang, Luyang Han, Yanbo Zhu, Jiawei Dong, Yuekang Xu, Xiaoying Liu, Jinyao Li   +7 more
wiley   +1 more source

LDLs stimulate p38 MAPKs and wound healing through SR-BI independently of Ras and PI3 kinases⃞

Journal of Lipid Research, 2009
Intracellular signals elicited by LDLs are likely to play a role in the pathogenesis associated with increased LDL blood levels. We have previously determined that LDL stimulation of human skin fibroblasts, used as a model system for adventitial ...
Natasa Bulat, Gérard Waeber, Christian Widmann   +2 more
doaj   +1 more source

Physiological roles of mitogen-activated-protein-kinase-activated p38-regulated/activated protein kinase

World Journal of Biological Chemistry, 2011
Mitogen-activated protein kinases (MAPKs) are a family of proteins that constitute signaling pathways involved in processes that control gene expression, cell division, cell survival, apoptosis, metabolism, differentiation and motility. The MAPK pathways can be divided into conventional and atypical MAPK pathways. The first group converts a signal into
Sergiy, Kostenko, Gianina, Dumitriu, Kari Jenssen, Lægreid, Ugo, Moens   +3 more
openaire   +2 more sources

Neuroprotective Effects of Tetrahydrocurcumin against Glutamate-Induced Oxidative Stress in Hippocampal HT22 Cells

Molecules, 2019
In the central nervous system, glutamate is a major excitable neurotransmitter responsible for many cellular functions. However, excessive levels of glutamate induce neuronal cell death via oxidative stress during acute brain injuries as well as chronic ...
Chang-Hyun Park, Ji Hoon Song, Su-Nam Kim, Ji Hwan Lee, Hae-Jeung Lee, Ki Sung Kang, Hyung-Ho Lim   +6 more
doaj   +1 more source

The impact of fruit flavonoids on memory and cognition [PDF]

, 2010
There is intense interest in the studies related to the potential of phytochemical-rich foods to prevent age-related neurodegeneration and cognitive decline.
Bhat, Haque, Jeremy P. E. Spencer, Joseph, Joseph, Joseph, Kempermann, Kuhn, Kuriyama, Spencer, Spencer   +10 more
core   +1 more source

Selective Activation of p38 Mitogen-activated Protein (MAP) Kinase Isoforms by the MAP Kinase Kinases MKK3 and MKK6*

Journal of Biological Chemistry, 1998
The cellular response to treatment with proinflammatory cytokines or exposure to environmental stress is mediated, in part, by the p38 group of mitogen-activated protein (MAP) kinases. We report the molecular cloning of a novel isoform of p38 MAP kinase,
H. Enslen, J. Raingeaud, R. Davis
semanticscholar   +1 more source

Hyperthermia-mediated cell death via deregulation of extracellular signal-regulated kinase and c-Jun NH2-terminal kinase signaling

Frontiers in Cell Death
Hyperthermia is a promising anticancer treatment that induces heat stress, thereby stimulating various signal transduction pathways to maintain cellular homeostasis.
Atsushi Enomoto, Takemichi Fukasawa, Takemichi Fukasawa, Ayumi Yoshizaki, Ayumi Yoshizaki   +4 more
doaj   +1 more source

Differential effects of ERK and p38 signaling in BMP-2 stimulated hypertrophy of cultured chick sternal chondrocytes [PDF]

, 2005
Background During endochondral bone formation, the hypertrophy of chondrocytes is accompanied by selective expression of several genes including type X collagen and alkaline phosphatase.
Golden, E.B., Grasso-Knight, G., Leboy, P.S., Reilly, G.C.   +3 more
core   +3 more sources