Crystal Structure of p38 Mitogen-activated Protein Kinase [PDF]
Journal of Biological Chemistry, 1996 p38 mitogen-activated protein kinase is activated by environmental stress and cytokines and plays a role in transcriptional regulation and inflammatory responses. The crystal structure of the apo, unphosphorylated form of p38 kinase has been solved at 2.3 A resolution. The fold and topology of p38 is similar to ERK2 (Zhang, F., Strand, A., Robbins, D.,
Matthew J. Fitzgibbon +7 more
openaire +3 more sources
Functions of p38 MAP Kinases in the Central Nervous System
Frontiers in Molecular Neuroscience, 2020 Mitogen-activated protein (MAP) kinases are a central component in signaling networks in a multitude of mammalian cell types. This review covers recent advances on specific functions of p38 MAP kinases in cells of the central nervous system.
Prita R. Asih +5 more
doaj +1 more source
Time courses of changes in phospho- and total- MAP kinases in the cochlea after intense noise exposure. [PDF]
PLoS ONE, 2013 Mitogen-activated protein kinases (MAP kinases) are intracellular signaling kinases activated by phosphorylation in response to a variety of extracellular stimuli.
Yukihide Maeda +4 more
doaj +1 more source
p38 mitogen-activated protein kinases: their role in carcinogenesis [PDF]
Revista de Oncología, 2003 [EN]: The members of the p38 subfamily of Mitogen-Activated Protein Kinases (MAPKs) are a versatile group of proteins, that function as signal transducers involved in key cellular functions. Initially, p38 MAPKs were associated with inflammatory and cellular stress responses and, as such, p38 has been an important target for anti-inflammatory therapies.
Sanz-Moreno, Victoria, Crespo, Piero
openaire +3 more sources
Co-regulation of the transcription controlling ATF2 phosphoswitch by JNK and p38
Nature Communications, 2020 The ATF2 transcription factor is phosphorylated by different mitogen-activated protein (MAP) kinases. Here, the authors show that the functionally distinct MAP kinases JNK and p38 control ATF2 through different binding sites and differential ...
Klára Kirsch +13 more
doaj +1 more source
Leishmania donovani promastigotes evade the activation of mitogen-activated protein kinases p38, c-Jun N-terminal kinase, and extracellular signal-regulated kinase-1/2 during infection of naive macrophages [PDF]
European Journal of Immunology, 2000 Charles Privé, Albert Descoteaux
openalex +2 more sources
DUSP1 is a novel target for enhancing pancreatic cancer cell sensitivity to gemcitabine. [PDF]
PLoS ONE, 2014 Pancreatic ductal adenocarcinoma (PDAC) is a deadly cancer with a poor prognosis that is characterized by excessive mitogenic pathway activation and marked chemoresistance to a broad spectrum of chemotherapeutic drugs.
Fang Liu +3 more
doaj +1 more source
Stress Relief Techniques: p38 MAPK Determines the Balance of Cell Cycle and Apoptosis Pathways
Biomolecules, 2021 Protein signaling networks are formed from diverse and inter-connected cell signaling pathways converging into webs of function and regulation. These signaling pathways both receive and conduct molecular messages, often by a series of post-translation ...
Robert H. Whitaker, Jeanette Gowen Cook
doaj +1 more source
Hepatology, EarlyView., 2022 Physiological activation of myeloid p38 controls macrophage IL‐12 production and crosstalk to the liver by modulating hepatic FGF21, and subsequently, brown adipose tissue thermogenesis during obesity Abstract Obesity features excessive fat accumulation in several body tissues and induces a state of chronic low‐grade inflammation that contributes to ...
María Crespo +14 more
wiley +1 more source
Role of p38 mitogen‐activated protein kinase in cardiac remodelling [PDF]
British Journal of Pharmacology, 2007 Background and purpose:Mitogen‐activated protein kinases (MAPK) are centrally involved in several mechanisms important for heart failure such as apoptosis, activation of inflammatory responses and cell proliferation. We therefore evaluated the effect of the selective p38 MAPK inhibitor SB 239063 on progression of left ventricular remodelling after ...
Kai Hu +8 more
openaire +3 more sources