Results 21 to 30 of about 57,894 (257)
Mediators of Inflammation, 2014 Inflammation is a natural host defensive process that is largely regulated by macrophages during the innate immune response. Mitogen-activated protein kinases (MAPKs) are proline-directed serine and threonine protein kinases that regulate many ...
Yanyan Yang +7 more
doaj +1 more source
Journal of Ginseng Research, 2019 Background: Thromboxane A2 (TXA2) induces platelet aggregation and promotes thrombus formation. Although ginsenoside Ro (G-Ro) from Panax ginseng is known to exhibit a Ca2+-antagonistic antiplatelet effect, whether it inhibits Ca2+-dependent cytosolic ...
Jung-Hae Shin +3 more
doaj +1 more source
p38 Mitogen-Activated Protein Kinases on the Body Surface – A Function for p38δ [PDF]
Journal of Investigative Dermatology, 2003 The p38 family of mitogen-activated protein kinases includes p38 alpha (SAPK2a, CSBP), p38 beta (SAPK2b), p38 delta (SAPK4), and p38 gamma (SAPK3/ERK6). p38 alpha and p38 beta are widely expressed p38 isoforms that are involved in regulation of cell proliferation, differentiation, development, and response to stress.
Eckert, Richard L. +5 more
openaire +2 more sources
Journal of Diabetes Investigation, 2019 Aims/Introduction To investigate the protective effect of Polygonatum sibiricum polysaccharide (PSP) on the retina in diabetic rats. Materials and Methods A total of 120 Sprague–Dawley rats were randomly divided into blank control, control model (meaning
Yi Wang +5 more
doaj +1 more source
The case for inhibiting p38 mitogen-activated protein kinase in heart failure
Frontiers in Pharmacology, 2015 This minireview discusses the evidence that the inhibition of p38 mitogen-activated protein kinases (p38 MAPKs) maybe of therapeutic value in heart failure. Most previous experimental studies, as well as past and ongoing clinical trials, have focussed on
Pelin eArabacilar, Michael eMarber
doaj +1 more source
Role of p38 Mitogen-Activated Protein Kinases in Preconditioning [PDF]
Circulation Research, 2000 Preconditioning, the phenomenon whereby brief episodes of ischemia or pharmacological agents protect the myocardium against subsequent ischemic injury, consists of an early and a late phase.1 The early phase develops immediately and disappears within 1 to 2 hours of ischemic preconditioning stimulus, whereas the late phase, also known as the “second ...
P, Ping, E, Murphy
openaire +2 more sources
Parasite, 2003 Host cell invasion is essential for the pathogenicity of the obligate intracellular protozoan parasite Toxoplasma gondii. In the present study, we evaluated the ability of T.
Valère A. +5 more
doaj +1 more source
Mitogen-activated protein kinases regulate susceptibility to ventilator-induced lung injury. [PDF]
PLoS ONE, 2008 Mechanical ventilation causes ventilator-induced lung injury in animals and humans. Mitogen-activated protein kinases have been implicated in ventilator-induced lung injury though their functional significance remains incomplete. We characterize the role
Tamás Dolinay +9 more
doaj +1 more source
Poultry Science, 2020 Defensins are antimicrobial peptides composed of 3 conserved disulfide bridges, a β-sheet, and both hydrophobic and cationic amino acids. In this study, we aimed to demonstrate the immunomodulation role of avian β-defensin 8 (AvBD8) in a chicken ...
Yeojin Hong +5 more
doaj +1 more source
Molecular Pain, 2017 Background Accumulating studies have suggested that remifentanil, the widely-used opioid analgesic in clinical anesthesia, can activate the pronociceptive systems and enhance postoperative pain.
Changxi Shi +9 more
doaj +1 more source