The role of p38 MAPK and its substrates in neuronal plasticity and neurodegenerative disease [PDF]
, 2012 A significant amount of evidence suggests that the p38-mitogen-activated protein kinase (MAPK) signalling cascade plays a crucial role in synaptic plasticity and in neurodegenerative diseases.
Eales, Katherine L. +1 more
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Octacalcium phosphate crystals directly stimulate expression of inducible nitric oxide synthase through p38 and JNK mitogen-activated protein kinases in articular chondrocytes [PDF]
, 2005 Basic calcium phosphate (BCP) crystals, including hydroxyapatite, octacalcium phosphate (OCP) and carbonate-apatite, have been associated with severe osteoarthritis and several degenerative arthropathies.
Uzan, Benjamin +3 more
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The role of endosomal escape and mitogen-activated protein kinases in adenoviral activation of the innate immune response. [PDF]
PLoS ONE, 2011 Adenoviral vectors (AdV) activate multiple signaling pathways associated with innate immune responses, including mitogen-activated protein kinases (MAPKs).
Jeffrey S Smith +5 more
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Role of p38 mitogen‐activated protein kinase in cardiac remodelling [PDF]
British Journal of Pharmacology, 2007 Background and purpose:Mitogen‐activated protein kinases (MAPK) are centrally involved in several mechanisms important for heart failure such as apoptosis, activation of inflammatory responses and cell proliferation. We therefore evaluated the effect of the selective p38 MAPK inhibitor SB 239063 on progression of left ventricular remodelling after ...
S, Frantz +8 more
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p38 Mitogen-Activated Protein Kinase and Hematologic Malignancies
Archives of Pathology & Laboratory Medicine, 2009 Abstract Context. —p38 mitogen-activated protein kinase (MAPK) signaling has been implicated in responses ranging from apoptosis to cell cycle, induction of expression of cytokine genes, and differentiation. This plethora of activators conveys the complexity of the p38 pathway.
Yongdong, Feng +2 more
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Modulation of autocrine TNF-α-stimulated matrix metalloproteinase 9 (MMP-9) expression by mitogenactivated protein kinases in THP-1 monocytic cells [PDF]
, 2006 Matrix metalloproteinase 9 (MMP-9) is implicated in various physiological processes by its ability to degrade the extracellular matrix (ECM) and process multiple regulatory proteins. Normally, MMP-9 expression is tightly controlled in cells. Sustained or
Helmut Kolb +9 more
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The p38/MK2 Axis in Monocytes of Fibromyalgia Syndrome Patients: An Explorative Study
Medicina, 2021 Background and Objectives: The aetiology and pathomechanism of fibromyalgia syndrome 12 (FMS) as one of chronic pain syndromes still need to be further elucidated.
Boya Nugraha +4 more
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Mediators of Inflammation, 2014 Inflammation is a natural host defensive process that is largely regulated by macrophages during the innate immune response. Mitogen-activated protein kinases (MAPKs) are proline-directed serine and threonine protein kinases that regulate many ...
Yanyan Yang +7 more
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Dynamic activation and regulation of the mitogen-activated protein kinase p38 [PDF]
Proceedings of the National Academy of Sciences, 2018 Significance The physical basis for the regulation of protein MAP kinases is key to understanding their role in cellular signaling in human biology and disease. However, the biochemical events that lead to MAPK activation are not well understood. Here, using biomolecular NMR dynamics measurements, we show that kinase activation is not
Ganesan Senthil Kumar +7 more
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The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice [PDF]
, 2010 Nearly every extracellular ligand that has been found to play a role in regulating bone biology acts, at least in part, through MAPK pathways. Nevertheless, much remains to be learned about the contribution of MAPKs to osteoblast biology in vivo. Here we
Zhai, Bo +33 more
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