Results 11 to 20 of about 57,894 (257)

Mitogen Activated Protein kinase signal transduction pathways in the prostate

Cell Communication and Signaling, 2004
The biochemistry of the mitogen activated protein kinases ERK, JNK, and p38 have been studied in prostate physiology in an attempt to elucidate novel mechanisms and pathways for the treatment of prostatic disease.
Koul Sweaty, Maroni Paul D, Meacham Randall B, Koul Hari K   +3 more
doaj   +1 more source

Myeloid p38 activation maintains macrophage–liver crosstalk and BAT thermogenesis through IL‐12–FGF21 axis

Hepatology, EarlyView., 2022
Physiological activation of myeloid p38 controls macrophage IL‐12 production and crosstalk to the liver by modulating hepatic FGF21, and subsequently, brown adipose tissue thermogenesis during obesity Abstract Obesity features excessive fat accumulation in several body tissues and induces a state of chronic low‐grade inflammation that contributes to ...
María Crespo, Ivana Nikolic, Alfonso Mora, Elena Rodríguez, Luis Leiva‐Vega, Aránzazu Pintor‐Chocano, Daniel Horrillo, Lourdes Hernández‐Cosido, Jorge L. Torres, Eva Novoa, Rubén Nogueiras, Gema Medina‐Gómez, Miguel Marcos, Magdalena Leiva, Guadalupe Sabio   +14 more
wiley   +1 more source

Isoform-specific and cell/tissue-dependent effects of p38 MAPKs in regulating inflammation and inflammation-associated oncogenesis

Frontiers in Bioscience-Landmark, 2022
p38 MAPK (mitogen-activated protein kinases) family proteins (α, β, γ and δ) are key inflammatory kinases and play an important role in relaying and processing intrinsic and extrinsic signals in response to inflammation, stress, and oncogene to regulate ...
Jian-Zhong Qin, Hong Xin, Xiao-Mei Qi, Guan Chen   +3 more
doaj   +1 more source

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source

The alkaloids of Corydalis hendersonii Hemsl. contribute to the cardioprotective effect against ischemic injury in mice by attenuating cardiomyocyte apoptosis via p38 MAPK signaling pathway

Chinese Medicine, 2023
Highlights The total extract of Corydalis hendersonii Hemsl. (CH) and the rich alkaloids fraction (RAF) of CH showed significant cardioprotective effect on mice following acute myocardial infarction.
Fuxing Ge, Xiaoli Gao, Xiaochun Zhou, Junjun Li, Xiaojing Ma, Meiwen Huang, Sana Wuken, Pengfei Tu, Chao An, Xingyun Chai   +9 more
doaj   +1 more source

Role of p38 mitogen‐activated protein kinase in cardiac remodelling [PDF]

British Journal of Pharmacology, 2007
Background and purpose:Mitogen‐activated protein kinases (MAPK) are centrally involved in several mechanisms important for heart failure such as apoptosis, activation of inflammatory responses and cell proliferation. We therefore evaluated the effect of the selective p38 MAPK inhibitor SB 239063 on progression of left ventricular remodelling after ...
S, Frantz, T, Behr, K, Hu, D, Fraccarollo, J, Strotmann, E, Goldberg, G, Ertl, C E, Angermann, J, Bauersachs   +8 more
openaire   +2 more sources

The role of endosomal escape and mitogen-activated protein kinases in adenoviral activation of the innate immune response. [PDF]

PLoS ONE, 2011
Adenoviral vectors (AdV) activate multiple signaling pathways associated with innate immune responses, including mitogen-activated protein kinases (MAPKs).
Jeffrey S Smith, Zhili Xu, Jie Tian, Donna J Palmer, Philip Ng, Andrew P Byrnes   +5 more
doaj   +1 more source

The p38/MK2 Axis in Monocytes of Fibromyalgia Syndrome Patients: An Explorative Study

Medicina, 2021
Background and Objectives: The aetiology and pathomechanism of fibromyalgia syndrome 12 (FMS) as one of chronic pain syndromes still need to be further elucidated.
Boya Nugraha, Renate Scheibe, Christoph Korallus, Matthias Gaestel, Christoph Gutenbrunner   +4 more
doaj   +1 more source

p38 Mitogen-Activated Protein Kinase and Hematologic Malignancies

Archives of Pathology & Laboratory Medicine, 2009
Abstract Context. —p38 mitogen-activated protein kinase (MAPK) signaling has been implicated in responses ranging from apoptosis to cell cycle, induction of expression of cytokine genes, and differentiation. This plethora of activators conveys the complexity of the p38 pathway.
Yongdong, Feng, Jianguo, Wen, Chung-Che Jeff, Chang   +2 more
openaire   +2 more sources

Dynamic activation and regulation of the mitogen-activated protein kinase p38 [PDF]

Proceedings of the National Academy of Sciences, 2018
Significance The physical basis for the regulation of protein MAP kinases is key to understanding their role in cellular signaling in human biology and disease. However, the biochemical events that lead to MAPK activation are not well understood.
Ganesan Senthil Kumar, Michael W. Clarkson, Micha B. A. Kunze, Daniele Granata, A. Joshua Wand, Kresten Lindorff-Larsen, Rebecca Page, Wolfgang Peti   +7 more
openaire   +3 more sources