Results 11 to 20 of about 4,400,135 (194)

p38 Mitogen-Activated Protein Kinases on the Body Surface – A Function for p38δ [PDF]

Journal of Investigative Dermatology, 2003
The p38 family of mitogen-activated protein kinases includes p38 alpha (SAPK2a, CSBP), p38 beta (SAPK2b), p38 delta (SAPK4), and p38 gamma (SAPK3/ERK6). p38 alpha and p38 beta are widely expressed p38 isoforms that are involved in regulation of cell proliferation, differentiation, development, and response to stress.
Eckert, Richard L., Efimova, Tatiana, Balasubramanian, Sivaprakasam, Crish, James F., Bone, Frederic, Dashti, Shervin   +5 more
openaire   +3 more sources

Targeting of p38 Mitogen-Activated Protein Kinases to MEF2 Transcription Factors [PDF]

Molecular and Cellular Biology, 1999
Mitogen-activated protein (MAP) kinase-mediated signalling to the nucleus is an important event in the conversion of extracellular signals into a cellular response. However, the existence of multiple MAP kinases which phosphorylate similar phosphoacceptor motifs poses a problem in maintaining substrate specificity and hence the correct biological ...
Yang S-H, Galanis A, Sharrocks AD
core   +6 more sources

Activation of the cellular mitogen-activated protein kinase pathways ERK, P38 and JNK during Toxoplasma gondii invasion

Parasite, 2003
Host cell invasion is essential for the pathogenicity of the obligate intracellular protozoan parasite Toxoplasma gondii. In the present study, we evaluated the ability of T.
Valère A., Garnotel R., Villena I., Guenounou M., Pinon J.M., Aubert D.   +5 more
doaj   +2 more sources

P38 mitogen-activated protein kinase and Parkinson’s disease [PDF]

Translational Neuroscience, 2018
AbstractParkinson’s disease, the second major neurodegenerative disease, has created a great impact on the elder people. Although the mechanisms underlying Parkinson’s disease are not fully understood, considerable evidence suggests that neuro-inflammation, oxidative stress, mitochondrial dysfunction, cell proliferation, differentiation and apoptosis ...
He Jianying, Zhong Wenwen, Zhang Ming, Zhang Rongping, Hu Weiyan   +4 more
openaire   +3 more sources

Stimulation of "stress-regulated" mitogen-activated protein kinases (stress-activated protein kinases/c-Jun N-terminal kinases and p38-mitogen-activated protein kinases) in perfused rat hearts by oxidative and other stresses.

, 1998
"Stress-regulated" mitogen-activated protein kinases (SR-MAPKs) comprise the stress-activated protein kinases (SAPKs)/c-Jun N-terminal kinases (JNKs) and the p38-MAPKs. In the perfused heart, ischemia/reperfusion activates SR-MAPKs. Although the agent(s)
Clerk, Angela, Sugden, P H, Michael, A, Fuller, S J   +3 more
core   +7 more sources

Phosphorylation of NFATc4 by p38 Mitogen-Activated Protein Kinases [PDF]

Molecular and Cellular Biology, 2002
Nuclear factor of activated T cells (NFAT) is implicated in multiple biological processes, including cytokine gene expression, cardiac hypertrophy, and adipocyte differentiation. A conserved NFAT homology domain is identified in all NFAT members.
Teddy T C, Yang, Qiufang, Xiong, Hervé, Enslen, Roger J, Davis, Chi-Wing, Chow   +4 more
openaire   +2 more sources

Crystal Structure of p38 Mitogen-activated Protein Kinase [PDF]

Journal of Biological Chemistry, 1996
p38 mitogen-activated protein kinase is activated by environmental stress and cytokines and plays a role in transcriptional regulation and inflammatory responses. The crystal structure of the apo, unphosphorylated form of p38 kinase has been solved at 2.3 A resolution. The fold and topology of p38 is similar to ERK2 (Zhang, F., Strand, A., Robbins, D.,
K P, Wilson, M J, Fitzgibbon, P R, Caron, J P, Griffith, W, Chen, P G, McCaffrey, S P, Chambers, M S, Su   +7 more
openaire   +2 more sources

Role of p38 mitogen-activated protein kinase isoforms in murine skin inflammation induced by 12-O-tetradecanoylphorbol 13-acetate [PDF]

, 2011
p38 mitogen-activated protein kinase plays a pivotal role in skin inflammation. The purpose of this study was to investigate the role of the various p38 isoforms. p38 beta/delta-knockout-C57BL/6 mice were generated, studied in a 12-O-tetradecanoylphorbol
Iversen, Lars, A Funding, JS Arthur, Johansen, Claus, Kragballe, Knud, BM Bibby, Lilleholt, Louise Langer, Funding, Anne, L Iversen, Bibby, Bo Martin, K Kragballe, C Johansen, Arthur, J. Simon C.; id_orcid, LL Lilleholt   +13 more
core   +1 more source

An overview of mammalian p38 mitogen-activated protein kinases, central regulators of cell stress and receptor signaling [PDF]

, 2020
The p38 family is a highly evolutionarily conserved group of mitogen-activated protein kinases (MAPKs) that is involved in and helps co-ordinate cellular responses to nearly all stressful stimuli.
Han, J, Wu, J, Silke, J
core   +1 more source

C-Jun N-terminal kinases/c-Jun and p38 pathways cooperate in ceramide-induced neuronal apoptosis [PDF]

, 2003
Understanding the regulation of the apoptotic program in neurons by intracellular pathways is currently a subject of great interest. Recent results suggest that c-Jun N-terminal kinases (JNK), mitogen-activated protein kinases and the transcription ...
Brugg, B., Caboche, J., Willaime-Morawek, S., Brami-Cherrier, K., Mariani, J.   +4 more
core   +1 more source