Results 231 to 240 of about 177,903 (366)

Differential effect of lead and cadmium on mitochondrial function and NLRP3 inflammasome activation in human trophoblast

The Journal of Physiology, EarlyView.
Abstract figure legend The human placenta not only detects the presence of Pb and Cd but also carries hypoxia and inflammatory risks, which are associated with pregnancy complications. To understand the impact of these factors on the placental trophoblast, we evaluated the effect of Pb and Cd on mitochondrial function and the NLRP3 inflammasome in ...
Yifeng Dai, Xijin Xu, Xia Huo, Joost H. N. Schuitemaker, Marijke M. Faas   +4 more
wiley   +1 more source

Expression of human collagenase‐3 (MMP‐13) by fetal skin fibroblasts is induced by transforming growth factor‐β via p38 mitogen‐activated protein kinase [PDF]

, 2000
Laura Ravanti, Mervi Toriseva, Risto Penttinen, Timothy M. Crombleholme, Marco Foschi, Jiahuai Han, Veli‐Matti Kähäri   +6 more
openalex   +1 more source

Human γδ T Cell Function Is Impaired Upon Mevalonate Pathway Inhibition

Immunology, Volume 175, Issue 3, Page 300-322, July 2025.
Mevalonate pathway is important for the effector function of gammadelta T cells. Inhibition of the pathway in vivo and in vitro impairs cytokine and cytotoxic molecule production by mainly affecting protein prenylation and disturbing intracellular signalling in Vdelta2 T cells. Created with Biorender.
Tsz Kin Suen, Burcu Al, Thomas Ulas, Nico Reusch, Harsh Bahrar, Siroon Bekkering, Jaydeep Bhat, Dieter Kabelitz, Joachim L. Schultze, Frank L. van de Veerdonk, Jeanine Roeters van Lennep, Niels P. Riksen, Leo A. B. Joosten, Mihai G. Netea, Katarzyna Placek   +14 more
wiley   +1 more source

Induction of cyclooxygenase‐2 expression in human myometrial smooth muscle cells by interleukin‐1β: involvement of p38 mitogen‐activated protein kinase

, 1999
Simon Bartlett, Robert Sawdy, Giovanni E. Mann   +2 more
openalex   +2 more sources

Role of p38 Mitogen-Activated Protein Kinase in Neointimal Hyperplasia After Vascular Injury [PDF]

, 2000
Naohiro Ohashi, Akira Matsumori, Yutaka Furukawa, Koh Ono, Masaharu Okada, Atsushi Iwasaki, Tadashi Miyamoto, Atsushi Nakano, Shigetake Sasayama   +8 more
openalex   +1 more source

Melatonin: A Potential Therapy for Osteoporosis With Insights Into Molecular Mechanisms

Journal of Pineal Research, Volume 77, Issue 4, July 2025.
ABSTRACT Melatonin is a versatile neurohormone with diverse molecular functions, including sleep regulation, inflammation reduction, antioxidant activity, immune modulation, and anticancer properties. In bone metabolism, it promotes osteoblast formation, inhibits osteoclast activity, and synchronizes skeletal tissue rhythms to support bone health.
Ko‐Hsiu Lu, Yi‐Hsien Hsieh, Renn‐Chia Lin, Meng‐Ying Tsai, Shun‐Fa Yang   +4 more
wiley   +1 more source

p38 Mitogen-activated Protein Kinase Negatively Regulates the Induction of Phase II Drug-metabolizing Enzymes That Detoxify Carcinogens [PDF]

, 2000
Rong Yu, Sandhya Mandlekar, Lei Wei, William E. Fahl, Tse‐Hua Tan, Angela Kong   +5 more
openalex   +1 more source

The Rac1/p38 Mitogen-activated Protein Kinase Pathway Is Required for Interferon α-dependent Transcriptional Activation but Not Serine Phosphorylation of Stat Proteins [PDF]

, 2000
Shahab Uddin, Fatima Lekmine, Niti Sharma, Beata Majchrzak, Ingrid A. Mayer, Peter R. Young, Gary Bokoch, Eleanor N. Fish, Leonidas C. Platanias   +8 more
openalex   +1 more source

Nuclear Translocation of S100A9 Triggers Senescence of Human Amnion Fibroblasts by De‐Repressing LINE1 Via Heterochromatin Erosion at Parturition

Advanced Science, Volume 12, Issue 21, June 5, 2025.
This study shows that the classical secretory protein S100 calcium‐binding protein A9 (S100A9) can translocate to the nucleus upon de‐phosphorylation at Thr 113 in human amnion fibroblasts at parturition, where S100A9 induces heterochromatin erosion through segregation of the heterochromatin maintenance protein, resulting inLong Interspersed Nuclear ...
Fan Zhang, Meng‐Die Li, Fan Pan, Wen‐Jia Lei, Yang Xi, Li‐Jun Ling, Leslie Myatt, Kang Sun, Wang‐Sheng Wang   +8 more
wiley   +1 more source

A Proteomics Profiling Reveals the Neuroprotective Effects of Melatonin on Exogenous β‐amyloid‐42 Induced Mitochondrial Impairment, Intracellular β‐amyloid Accumulation and Tau Hyperphosphorylation in Human SH‐SY5Y Cells

Cell Biology International, Volume 49, Issue 6, Page 659-673, June 2025.
ABSTRACT Alzheimer's disease (AD) is prevalent in the elderly population and characterized by the intracellular accumulation of neurofibrillary tangles (NFTs), composed of tau proteins, and extracellular deposition of beta‐amyloid protein (Aβ). The present study aimed to investigate the neuroprotective effects of melatonin on Aβ42‐induced AD‐like ...
Jiraporn Panmanee, Matthew Phanchana, Phorutai Pearngam, Nopphon Petchyam, Kornkanok Promthep, Ponlawit Wisomka, Suchanoot Kutpruek, Supitcha Pannengpetch, Tanya Prasertporn, Sujira Mukda, Piyarat Govitrapong, Chutikorn Nopparat   +11 more
wiley   +1 more source