Results 221 to 230 of about 57,894 (257)

Role of p38 Mitogen-Activated Protein Kinase in Thrombus Formation

Journal of Receptors and Signal Transduction, 2004
The present study was designed to elucidate the role of p38 mitogen-activated protein kinase (p38) in thrombus formation. We used p38alpha heterozygous (p38alpha+/-) mice and used ferric chloride (FeCl3)-induced carotid artery injury as a model of thrombus formation.
Kanako, Sakurai, Yuji, Matsuo, Tatsuhiko, Sudo, Yoh, Takuwa, Sadao, Kimura, Yoshitoshi, Kasuya   +5 more
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Current Insights of Inhibitors of p38 Mitogen-Activated Protein Kinase in Inflammation

Medicinal Chemistry, 2021
Background:: Inflammatory process is one of the mechanisms by which our body upholds us from pathogens such as parasites, bacteria, viruses, and other harmful microorganisms. Inflammatory stimuli activate many intracellular signaling pathways such as nuclear factor-kB (NF-kB) pathway and three mitogen-activated protein kinase (MAPK) pathways which ...
Archana, Awasthi, Mantripragada Bhagavan, Raju, Md Azizur, Rahman   +2 more
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p38 Mitogen-Activated Protein Kinase (MAPK) in Rheumatoid Arthritis

Mini-Reviews in Medicinal Chemistry, 2006
The importance of p38 MAPK inhibitors as new drug for rheumatoid arthritis is reflected by the large number of compounds that has been developed over the last years. In this review new insights such as non-stressful activation of p38 MAPK, and the role of p38 MAPK in regulation of NF-kappaB recruitment are also discussed.
J, Westra, P C, Limburg
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Analyzing JNK and p38 mitogen-activated protein kinase activity

2001
Publisher Summary The JNK and p38 mitogen-activated protein (MAP) kinase groups are important for many physiological processes including cell growth, oncogenic transformation, cell differentiation, apoptosis, and the immune response. To understand the role of JNK and p38 MAP kinases in the cell, several protocols for measuring their activation state ...
Whitmarsh, A. J., Davis, R. J.
openaire   +3 more sources

Inhibitors of p38 Mitogen-Activated Protein Kinase

BioDrugs, 2003
Asthma is an inflammatory disease of the airways, which in patients with mild to moderate symptoms is adequately controlled by either beta(2)-adrenoceptor agonists or corticosteroids, or a combination of both. Despite this, there are classes of patients that fail to respond to these treatments.
Robert, Newton, Neil, Holden
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Dehydroepiandrosterone negatively regulates the p38 mitogen-activated protein kinase pathway by a novel mitogen-activated protein kinase phosphatase

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 2005
Dehydroepiandrosterone-sulfate, the sulfated form of dehydroepiandrosterone, is the most abundant steroid in young adults, but gradually declines with aging. In humans, the clinical application of dehydroepiandrosterone targeting some collagen diseases, such as systemic lupus erythematosus, as an adjunctive treatment has been applied in clinical trial.
Kenji, Ashida, Kiminobu, Goto, Yue, Zhao, Taijiro, Okabe, Toshihiko, Yanase, Ryoichi, Takayanagi, Masatoshi, Nomura, Hajime, Nawata   +7 more
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p38 Mitogen-Activated Protein Kinase Pathways in Asthma and COPD

Chest, 2011
The mitogen-activated protein kinase (MAPK) family includes the p38 kinases, which consist of highly conserved proline-directed serine-threonine protein kinases that are activated in response to inflammatory signals. Of the four isoforms, p38α is the most abundant in inflammatory cells and has been the most studied through mainly the availability of ...
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Role of p38 mitogen-activated protein kinase in posttraumatic immunosuppression in mice

Journal of Trauma and Acute Care Surgery, 2012
Patients with multiple injuries surviving the initial insult are highly susceptible to secondary pneumonia, frequently progressing into sepsis and multiorgan failure. However, the underlying mechanisms of posttraumatic immunosuppression are poorly understood.
Nadine, Ding, Katja, Dahlke, Ann-Kathrin, Janze, Petra C, Mailer, Regina, Maus, Jennifer, Bohling, Tobias, Welte, Michael, Bauer, Niels C, Riedemann, Ulrich A, Maus   +9 more
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p38 Mitogen-Activated Protein Kinase Inhibitors— Mechanisms and Therapeutic Potentials

Pharmacology & Therapeutics, 1999
The pyridinylimidazole compounds, exemplified by SB 203580, originally were prepared as inflammatory cytokine synthesis inhibitors. Subsequently, the compounds were found to be selective inhibitors for p38 mitogen-activated protein kinase (MAPK), a member of the MAPK family.
J C, Lee, S, Kassis, S, Kumar, A, Badger, J L, Adams   +4 more
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Activation of p38 Mitogen-activated Protein Kinase in Rat Periapical Lesions

Journal of Endodontics, 2008
The purpose of this study was to investigate the activation of p38 mitogen-activated protein kinase (MAPK) during the development of periapical lesions in rats. Periapical lesions developed within 28 days after pulp exposure of mandibular first molars in Wistar rats.
Rui, Zhang, Li, Wang, Bin, Peng
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