Results 201 to 210 of about 58,168 (261)

IRF‐1 modulates hepatic ferroptosis and aggravates liver ischemia/reperfusion injury via DYRK1α

Animal Models and Experimental Medicine, Volume 9, Issue 8, Page 1587-1601, August 2026.
IRF‐1 modulates hepatic ferroptosis and aggravates liver ischemia/reperfusion injury via DYRK1α. Abstract Background The purpose is to define the contribution of the interferon regulatory factor‐1–dual‐specificity tyrosine phosphorylation‐regulated kinase 1α (IRF‐1–DYRK1α) axis to hepatocellular ferroptosis during liver ischemia/reperfusion injury ...
Jinping Zhang, Jinming Zhang, Siyuan Song, Mingyang Li, Liying Sun, Zhijun Zhu, Dongdong Lin   +6 more
wiley   +1 more source

Intracellular NAD⁺ Depletion Increases Prostanoid Production via p38/COX2 Signalling in FK866-Induced Senescent Human Umbilical Vein Endothelial Cells. [PDF]

J Cell Mol Med
Kitajima N, Nakajo T, Katayoshi T, Tsuji K.   +3 more
europepmc   +1 more source

Prunetin Attenuates Dexamethasone‐Induced Pancreatic β‐Cell Apoptosis: Modulation of Oxidative Stress and MAPK Signaling but Not Phosphorylated C‐Abl Levels

Cell Biochemistry and Function, Volume 44, Issue 8, August 2026.
ABSTRACT Dexamethasone has been reported to induce pancreatic β‐cell apoptosis, which may contribute to steroid‐induced diabetes following long‐term glucocorticoid therapy. Although prunetin, a natural isoflavone, has been shown to attenuate dexamethasone‐induced pancreatic β‐cell apoptosis with suppression of p53 signaling as an associated pathway ...
Thaksaon Kittipassorn, Nawarat Rattanajearakul, Petcharee Maneethorn, Namoiy Semprasert, Suwattanee Kooptiwut   +4 more
wiley   +1 more source

Endothelial dysfunction in aging associated with reduced Niban phosphorylation. [PDF]

Mol Biol Rep
Baer B, Morelli M, Brophy C, Bastarache JA, Cheung-Flynn J.   +4 more
europepmc   +1 more source

The Serotonin 2B (5‐HT2B) Receptor: A Narrative Review of Preclinical and Clinical Evidence on the Safety Considerations and Therapeutic Potential for the Treatment of Depression

Clinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 345-356, August 2026.
Major depressive disorder (MDD) and treatment‐resistant depression (TRD) remain leading causes of disability, providing the impetus for receptor‐level treatment strategies beyond monoamine reuptake. The serotonin 5‐HT2B receptor (5‐HT2BR) is uniquely positioned at the interface of central‐antidepressant mechanisms and peripheral cardiac risks.
Gia Han Le, Sabrina Wong, Danica E. Johnson, Diana K. Orsini, Yang Jing Zheng, Kayla M. Teopiz, Christine E. Dri, Joshua D. Rosenblat, Roger S. McIntyre   +8 more
wiley   +1 more source

From gatekeeper to target: MAPK cascades as control circuits at the insect-microbe interface. [PDF]

FEMS Microbiol Rev
Kang S, Bai Y, Crickmore N, Soberón M, Zhou X, Zhang Y, Bravo A, Guo Z.   +7 more
europepmc   +1 more source

Mesenchymal stem cell‐derived exosomes for cardiac repair: Challenges, standardization gaps and a realistic path to clinical translation

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
Mesenchymal stem cell‐derived exosomes (MSC‐sEVs) show preclinical promise for cardiac repair via anti‐inflammatory, anti‐apoptotic, pro‐angiogenic and anti‐fibrotic effects. However, translational hurdles remain, including non‐standardized isolation, unvalidated potency assays, incomplete GMP manufacturing, and lack of completed Phase II/III trials ...
Sakhavat Abolhasani, Yasin Ahmadi, Amin Jalizih   +2 more
wiley   +1 more source

MK2/p38/p53 Suppress Basal IL-1β and Non-Canonical NF-κB Signaling in Macrophages. [PDF]

Int J Mol Sci
Herr SM, Stalkopf D, Padaszus S, Herbst LA, Dörrie A, Niedenthal R, Ronkina N, Yakovleva T, Kotlyarov A, Gaestel M.   +9 more
europepmc   +1 more source

Advancing gambogic acid for translational oncology: Redox–proteostasis collapse, multidrug resistance reversal, nanodelivery and biomarker‐guided development

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
Gambogic acid exerts anticancer effects through reactive oxygen species‐mediated apoptosis, suppression of nuclear factor kappa B and phosphatidylinositol‐3‐kinase–protein kinase B signalling, multidrug resistance modulation and tumour microenvironment effects.
Uttam Singh Baghel, Kajal Gurow, Geetanjali Mehara, Priyanka Kriplani, Neelam M. Patel, Abhay Sharma, Deeksha Singh, Atamjit Singh, Suchi Dave, Bhawani Singh, Lashyn N. Kiyekbayeva, William N. Setzer, Javad Sharifi‐Rad, Cheryl Grace Pratiwi Rumahorbo, Daniela Calina   +14 more
wiley   +1 more source

Targeting the MAPK Pathway in Cancer. [PDF]

Int J Mol Sci
Kadasah SF.
europepmc   +1 more source