Results 201 to 210 of about 57,894 (257)

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, Volume 293, Issue 13, Page 3717-3757, July 2026.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

Targeting the MAPK Pathway in Cancer. [PDF]

Int J Mol Sci
Kadasah SF.
europepmc   +1 more source

Interactions between small leucine‐rich proteoglycans and proteases: implications for tissue homeostasis and pathology

The FEBS Journal, Volume 293, Issue 13, Page 3848-3864, July 2026.
Small leucine‐rich proteoglycans (SLRPs) are key modulators of extracellular matrix structure and signaling. Their proteolytic processing by MMPs (Matrix Metalloproteinases), ADAMTS (disintegrin and metalloprotease with thrombospondin motifs), and serine proteases generates bioactive fragments that regulate collagen remodeling, inflammation, and ...
Maria Konstantaraki, Lydia‐Nefeli Thrapsanioti, Aikaterini Berdiaki, Ioanna Spyridaki, Dragana Nikitovic   +4 more
wiley   +1 more source

Regulation of Cell Proliferation and Migration by Extracellular Phosphatidic Acid. [PDF]

Biomedicines
Gomez-Larrauri A, Benito-Vicente A, Uribe KB, Martin C, Gomez-Muñoz A.   +4 more
europepmc   +1 more source

circFOXP1 Promotes Pancreatic Ductal Adenocarcinoma Progression Through Regulating EREG/MAPK/ERK Axis

Journal of Cellular and Molecular Medicine, Volume 30, Issue 13, July 2026.
ABSTRACT Circular RNAs (circRNAs) are indispensable for triggering pancreatic ductal adenocarcinoma (PDAC) progression. However, the specific biological processes and mechanisms by which circRNAs influence PDAC remain largely unknown. Here, we reported that circFOXP1 is a critical promoter of PDAC progression, exhibiting marked upregulation in patient ...
Leyi Huang, Dan Su, Rihua He, Bingzheng Zhong, Qiang Wang, Fuxu Feng, Jingwen Li, Jie Cao, Quanbo Zhou, Xiaofeng Guo   +9 more
wiley   +1 more source

Immune regulation of Chidamide-induced Linc01010 accumulation in breast cancer cell death. [PDF]

World J Clin Oncol
Han H, Guo XY, Wen JX, Zhao XM, Zhou WQ.
europepmc   +1 more source

Mitogen-Activated Protein Kinases: Therapeutic Signaling Catalysts in Viral Immune Evasion. [PDF]

Pathogens
Khan MA, Khan MH, Allemailem KS.
europepmc   +1 more source

An inhibitor of GCN2 and the integrated stress response directly targets ZAK protein kinase to limit cytotoxicity. [PDF]

J Biol Chem
Misra J, Spandau DF, Vilseck JZ, Anthony TG, Staschke KA, Wek RC.   +5 more
europepmc   +1 more source

The stress-activated kinase p38 mediates non-canonical activation of Src and tyrosine phosphorylation of the adapter protein TAB1. [PDF]

J Biol Chem
Onuma I, Iwata Y, Zhou Y, Nakada M, Kondo A, Iwahara H, Natori K, Yokoyama S, Chihara K, Takeuchi K, Sada K, Ozawa T, Mizuguchi M, Yamagishi N, Kracht M, Sakurai H.   +15 more
europepmc   +1 more source

IL-6 exacerbates calcium oxalate kidney stones by promoting inflammatory responses and crystal adhesion via p38 MAPK signaling activation. [PDF]

Urolithiasis
Liang F, Guo F, Han Z, Xiang Y, Guan X, Wang X.   +5 more
europepmc   +1 more source