Results 191 to 200 of about 57,894 (257)

Atherosclerosis: Molecular Pathogenesis and Therapeutic Interventions

MedComm, Volume 7, Issue 7, July 2026.
Molecular factors, like transforming growth factor beta (TGF‐β), mitogen‐activated protein kinase (MAPK), phosphoinositide 3‐kinase (PI3K), or cyclin‐dependent kinases (CDKs) 5 and 9, are essential modulators of atherosclerotic lesions. The novel, promising strategies for atherosclerosis treatment include therapies based on small interfering RNA (siRNA)
Jonatan Kaszubski, Agata Wawrzyniak, Maciej Gagat, Agnieszka Żuryń   +3 more
wiley   +1 more source

Endothelial dysfunction in aging associated with reduced Niban phosphorylation. [PDF]

Mol Biol Rep
Baer B, Morelli M, Brophy C, Bastarache JA, Cheung-Flynn J.   +4 more
europepmc   +1 more source

Urologic Bacteriome: The Hero or the Villain in Prostate Cancer Onset, Progression, and Treatment?

Medicinal Research Reviews, Volume 46, Issue 4, Page 1111-1151, July 2026.
ABSTRACT Prostate cancer (PCa) is the second most frequently diagnosed cancer in men worldwide and the fifth leading cause of cancer‐related mortality, presenting urgent unmet clinical needs in diagnosis and treatment. The recognition of the microbiome as a key factor in human health has prompted numerous studies, revealing an exciting new approach to ...
Lara R. S. Fonseca, Mariana Feijó, Cátia V. Vaz, Bruno J. Pereira, Sandra Laurentino, Ana Palmeira‐de‐Oliveira, Sílvia Socorro   +6 more
wiley   +1 more source

Intracellular NAD⁺ Depletion Increases Prostanoid Production via p38/COX2 Signalling in FK866-Induced Senescent Human Umbilical Vein Endothelial Cells. [PDF]

J Cell Mol Med
Kitajima N, Nakajo T, Katayoshi T, Tsuji K.   +3 more
europepmc   +1 more source

Endoplasmic reticulum stress and the unfolded protein response in lung diseases: molecular pathways and therapeutic interventions

The Journal of Pathology, Volume 269, Issue 3, Page 268-283, July 2026.
Abstract Endoplasmic reticulum stress (ERS) occurs when the protein‐folding capacity of the endoplasmic reticulum (ER) is overwhelmed, triggering the unfolded protein response (UPR) to restore homeostasis. However, severe or persistent ERS can shift the UPR toward pro‐inflammatory, apoptotic, and fibrotic signaling, thereby exacerbating tissue injury ...
Lanlan Song, Yichen Liu, Chen Xu, Yaochen Zhang, Kaiming Xu, Dan Yao, Xiaoying Huang   +6 more
wiley   +1 more source

Saffron and <i>Calculus bovis</i> combination exerts anti-hepatic fibrotic effect in liver fibrosis rats <i>via</i> the mitogen-activated protein kinases pathway. [PDF]

World J Gastroenterol
Sun SN, Wang K, Xu Y, Ye F, Xia WN, Wang ZW, Liu F, He ZX, Chen M, Du QH.   +9 more
europepmc   +1 more source

Flavonoids in Nasal Therapeutics: Biological Activities, Delivery Challenges, and Formulation Strategies–A Systematic Review

Phytotherapy Research, Volume 40, Issue 7, Page 4676-4709, July 2026.
Overview of the therapeutic potential of flavonoids in nasal delivery systems, highlighting their benefits to the human nasal cavity, and applications in the treatment of respiratory and brain‐related diseases. ABSTRACT Flavonoids represent a significant group of secondary metabolites.
Jeniffer Viviana Ramirez Hernández, Sara Elis Bianchi, Flávia Nathiely Silveira Fachel, Elizandra Braganhol, Sheila Porto de Matos, Valquíria Linck Bassani   +5 more
wiley   +1 more source

Autophagy-Apoptosis Crosstalk in Cancer: Mechanisms, Signaling Pathways, and Therapeutic Targeting. [PDF]

Cancers (Basel)
Kakkar D, Saxena S, Dhawan U, Dosi N, Khanna C, Paul S.   +5 more
europepmc   +1 more source

Engineering Functional Graphenic Materials for Bone Repair

WIREs Nanomedicine and Nanobiotechnology, Volume 18, Issue 4, July/August 2026.
Graphene oxide (GO) and its derivatives have many favorable properties for biomedical applications. This is due to the inherent properties of GO including high surface area, functionalizability, mechanical strength, and bioresorbable nature, among other properties outlined above.
Sebastian Guajardo, Jason D. Orlando, Chenyun Deng, Anne M. Arnold, Stefanie A. Sydlik   +4 more
wiley   +1 more source

MK2/p38/p53 Suppress Basal IL-1β and Non-Canonical NF-κB Signaling in Macrophages. [PDF]

Int J Mol Sci
Herr SM, Stalkopf D, Padaszus S, Herbst LA, Dörrie A, Niedenthal R, Ronkina N, Yakovleva T, Kotlyarov A, Gaestel M.   +9 more
europepmc   +1 more source