Results 171 to 180 of about 58,168 (261)

2‐Hydroxyethyl Methacrylate Increases MMP‐1 and MMP‐3 Production in Human Gingival Fibroblasts

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
HEMA induces the production of MMP‐1 and MMP‐3 in human gingival fibroblasts by activating the p38 MAPK, JNK, and Akt signaling pathways. ABSTRACT 2‐Hydroxyethyl methacrylate (HEMA), a monomer commonly used in dental resin materials, has been reported to leach from polymerized resins.
Risa Okamoto, Yoshitaka Hosokawa, Ikuko Hosokawa, Ai Fukui, Natsuho Miyake, Kazumi Ozaki, Keiichi Hosaka   +6 more
wiley   +1 more source

Role of Medullary AKT and p38 MAPK in Regulating Feeding of Broiler Chicks. [PDF]

J Poult Sci
Saneyasu T, Kaihatsu M, Nagata K, Kitayama A, Sakai H, Kamisoyama H, Takegaki J, Honda K.   +7 more
europepmc   +1 more source

Icariside II in Neurological Disorders: Mechanistic Insights Into Alzheimer's Disease, Cerebral Ischemia and Parkinson's Disease

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
The graphical abstract represents the underlying neuroprotective potential of ICS II against Alzheimer's disease, Cerebral ischemia and Parkinson disease. ICS II downregulates ROS production, inflammation, mitochondrial dysfunction and apoptosis along with regulating their key signalling pathways.
Ashutosh Solanki, Khushi Sharma, Jagrati Jain, Niraj Kumar Singh, Praveen T. Krishnamurthy   +4 more
wiley   +1 more source

Forchlorfenuron Exposure Induces Hepatocyte Apoptosis via MKK3/P38/ATF2 Pathway. [PDF]

Int J Mol Sci
Zhang Y, Luo Y, Che X, Dai Z, Sun X, Sun X.   +5 more
europepmc   +1 more source

Improving Proteolysis‐Targeting Chimera Delivery by Targeting Key Biomarkers in Tumor Endocytosis Pathways

MedComm – Biomaterials and Applications, Volume 5, Issue 3, September 2026.
The image illustrates how PROTACs utilize endocytosis, mediated by cell surface proteins, to overcome bioavailability limitations and enable efficient intracellular delivery. ABSTRACT Proteolysis‐targeting chimeras (PROTACs) are promising therapeutic agents for targeted protein degradation via the ubiquitin‐proteasome system; however, their clinical ...
Huahua Chen, Jiayan Jiao, Huiling Yang, Tao He   +3 more
wiley   +1 more source

Analysis of CacyBP/SIP, ERK1/2, and p38 Expression in Low- and High-Grade Papillary Urothelial Carcinoma. [PDF]

Cancer Med
Domian N, Młynarczyk G, Kasacka I.
europepmc   +1 more source

Cyclins and Cyclin‐Dependent Kinases: Structure, Biological Functions, and Innovative Targeting Strategies in Cancer

MedComm, Volume 7, Issue 9, September 2026.
This work synthesizes recent insights into the pathological roles of cyclins and cyclin‐dependent kinases (CDKs) across human cancers, highlights state‐of‐the‐art innovative approaches (especially targeted degradation and redistribution of CDK/cyclin proteins) for cancer therapy, and outlines future directions for CDK/cyclin‐related biomedical research.
Suya Zheng, Zhipeng Shen, Yuanfang Wu, Xingze Huang, Zhongyuan Zhang, Jiangyu Liu, Qichun Wei, Wenhao Chen, Ye Chen, Liang Xu   +9 more
wiley   +1 more source

[Expression of Concern] Visfatin/PBEF/Nampt induces EMMPRIN and MMP‑9 production in macrophages via the NAMPT‑MAPK (p38, ERK1/2)‑NF‑κB signaling pathway. [PDF]

Int J Mol Med
Fan Y, Meng S, Wang Y, Cao J, Wang C.
europepmc   +1 more source

Advances in FGF/FGFR Signaling: Implications for Disease and Therapy

MedComm, Volume 7, Issue 9, September 2026.
The FGF/FGFR signaling is indispensable for the maintenance of physiological homeostasis and governs multiple biological processes, including embryonic development, bone metabolism, angiogenesis, and neurogenesis, whereas aberrant hyperactivation of this pathway drives the progression of malignancies and autoimmune disorders, including inflammatory ...
Miaoyu Song, Xi Liu, Yang Xiao, Yongsheng Li, Huakan Zhao   +4 more
wiley   +1 more source

Anti-Inflammatory Effects of Progesterone on Human Microglia via TLR4/NLRP3 Pathway Modulation: Relevance to Drug-Resistant Epilepsy. [PDF]

Pharmaceuticals (Basel)
Meanti R, Criscione ML, Sartori E, Rizzi L, Bresciani E, Mauri M, Omeljaniuk RJ, Biagini G, Torsello A.   +8 more
europepmc   +1 more source