Hsp90 as a master regulator in autoimmunity: from cellular stress to clinical opportunity. [PDF]
Scarneo S, Freeze R, Haystead TA.
europepmc +1 more source
Intersection of inflammation and viral replication: the central role of MAPK signaling in viral respiratory infections. [PDF]
Tripp RA, Jones LP, Martin DE.
europepmc +1 more source
Endothelin-1 Signaling Mediates Hypoxia-Induced Microglial Activation Through Reactive Oxygen Species and Mitogen-Activated Protein Kinase Pathways. [PDF]
Garcia Y +6 more
europepmc +1 more source
Cuproptosis in Inflammation-Related Respiratory Diseases. [PDF]
Fu Q +7 more
europepmc +1 more source
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p38 mitogen-activated protein kinase and pain
Life Sciences, 2020Inflammatory and neuropathic pain is initiated by tissue inflammation and nerve injury, respectively. Both are characterized by increased activity in the peripheral and central nervous system, where multiple inflammatory cytokines and other active molecules activate different signaling pathways that involve in the development and/or maintenance of pain.
Lijia, Mai +4 more
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p38 Mitogen-Activated Protein Kinase Regulates Myelination
Journal of Molecular Neuroscience, 2007The p38 mitogen-activated protein kinase family is emerging as a crucial signaling molecule for a vast number of cellular functions including cell migration, proliferation, and differentiation. The function of p38 in myelination has only been recently addressed.
Jeffery D, Haines +4 more
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Role of p38 Mitogen-Activated Protein Kinase in Thrombus Formation
Journal of Receptor and Signal Transduction Research, 2004The present study was designed to elucidate the role of p38 mitogen-activated protein kinase (p38) in thrombus formation. We used p38alpha heterozygous (p38alpha+/-) mice and used ferric chloride (FeCl3)-induced carotid artery injury as a model of thrombus formation.
Yoh Takuwa +2 more
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Current Insights of Inhibitors of p38 Mitogen-Activated Protein Kinase in Inflammation
Medicinal Chemistry, 2021Background:: Inflammatory process is one of the mechanisms by which our body upholds us from pathogens such as parasites, bacteria, viruses, and other harmful microorganisms. Inflammatory stimuli activate many intracellular signaling pathways such as nuclear factor-kB (NF-kB) pathway and three mitogen-activated protein kinase (MAPK) pathways which ...
Archana, Awasthi +2 more
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p38 Mitogen-Activated Protein Kinase (MAPK) in Rheumatoid Arthritis
Mini-Reviews in Medicinal Chemistry, 2006The importance of p38 MAPK inhibitors as new drug for rheumatoid arthritis is reflected by the large number of compounds that has been developed over the last years. In this review new insights such as non-stressful activation of p38 MAPK, and the role of p38 MAPK in regulation of NF-kappaB recruitment are also discussed.
J, Westra, P C, Limburg
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