Results 151 to 160 of about 4,400,135 (194)

Endothelin-1 Signaling Mediates Hypoxia-Induced Microglial Activation Through Reactive Oxygen Species and Mitogen-Activated Protein Kinase Pathways. [PDF]

open access: yesASN Neuro
Garcia Y   +6 more
europepmc   +1 more source

Cuproptosis in Inflammation-Related Respiratory Diseases. [PDF]

open access: yesInt J Mol Sci
Fu Q   +7 more
europepmc   +1 more source

p38 mitogen-activated protein kinase and pain

Life Sciences, 2020
Inflammatory and neuropathic pain is initiated by tissue inflammation and nerve injury, respectively. Both are characterized by increased activity in the peripheral and central nervous system, where multiple inflammatory cytokines and other active molecules activate different signaling pathways that involve in the development and/or maintenance of pain.
Lijia, Mai   +4 more
openaire   +2 more sources

p38 Mitogen-Activated Protein Kinase Regulates Myelination

Journal of Molecular Neuroscience, 2007
The p38 mitogen-activated protein kinase family is emerging as a crucial signaling molecule for a vast number of cellular functions including cell migration, proliferation, and differentiation. The function of p38 in myelination has only been recently addressed.
Jeffery D, Haines   +4 more
openaire   +2 more sources

Role of p38 Mitogen-Activated Protein Kinase in Thrombus Formation

Journal of Receptor and Signal Transduction Research, 2004
The present study was designed to elucidate the role of p38 mitogen-activated protein kinase (p38) in thrombus formation. We used p38alpha heterozygous (p38alpha+/-) mice and used ferric chloride (FeCl3)-induced carotid artery injury as a model of thrombus formation.
Yoh Takuwa   +2 more
exaly   +3 more sources

Current Insights of Inhibitors of p38 Mitogen-Activated Protein Kinase in Inflammation

Medicinal Chemistry, 2021
Background:: Inflammatory process is one of the mechanisms by which our body upholds us from pathogens such as parasites, bacteria, viruses, and other harmful microorganisms. Inflammatory stimuli activate many intracellular signaling pathways such as nuclear factor-kB (NF-kB) pathway and three mitogen-activated protein kinase (MAPK) pathways which ...
Archana, Awasthi   +2 more
openaire   +2 more sources

p38 Mitogen-Activated Protein Kinase (MAPK) in Rheumatoid Arthritis

Mini-Reviews in Medicinal Chemistry, 2006
The importance of p38 MAPK inhibitors as new drug for rheumatoid arthritis is reflected by the large number of compounds that has been developed over the last years. In this review new insights such as non-stressful activation of p38 MAPK, and the role of p38 MAPK in regulation of NF-kappaB recruitment are also discussed.
J, Westra, P C, Limburg
openaire   +2 more sources

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