Results 161 to 170 of about 57,894 (257)

Expression of ERK1/2, p38, and JNK in Normal Kidney Development and CAKUT. [PDF]

Medicina (Kaunas)
Letica I, Todorović P, Bajt P, Pavlović N, Kelam N, Raguž MJ, Mikulić I, Letica L, Kostić S, Vukojević K, Racetin A.   +10 more
europepmc   +1 more source

Immunomodulatory Potential of Quinoline Q3, a Selective Inhibitor of the Canonical NF‐κB Pathway in Macrophages

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
The quinolone Q3 specifically enhances the DNA binding of the p50/p50 NF‐κB dimers, while inhibiting the activity of the p65 transcriptional activator, resulting in inhibition of the NF‐κB canonical pathway in lipopolysaccharide (LPS)‐stimulated macrophages.
Konstantinos Michail, Panagiotis Ntavaroukas, Vasiliki Petriki, Evangelos Tsioupros, Stella Manta, Barry J. Campbell, Stamatia Papoutsopoulou   +6 more
wiley   +1 more source

Cucurbitacin B Promotes Tumor Necrosis Factor Receptor 1 Ectodomain Shedding by Selectively Activating the Extracellular Signal-Regulated Kinase Signaling Pathway. [PDF]

Int J Mol Sci
Yarangsee P, Fukai I, Phol S, Kinugawa K, Kusagawa E, Miyake Y, Kataoka T.   +6 more
europepmc   +1 more source

A Bifunctional T3SS‐Effector Simultaneously Cleaves Host MAP Kinase and Inhibits PPM1A Phosphatase

Advanced Science, Volume 13, Issue 37, 3 July 2026.
Pathogenic bacteria exploit the metalloprotease effector NleD to subvert host defenses. Structural, biochemical, and infection analyses reveal a bifunctional mechanism by which NleD binds and inhibits the host phosphatase PPM1A while preserving its proteolytic activity against MAPKs.
Yaakov Socol, Lihi Gur‐Arie, Netanel Tzarum, Tamara Wellins, Naama Katsowich, Miriam Ravins, Michal Bejerano‐Sagie, Klil Cohen, Oded Livnah, Joshua N. Adkins, Ernesto Nakayasu, Alexei Savchenko, Yeu Khai Choong, Nikhil Kumar Tulsian, Saturo Machida, Sigal Ben‐Yehuda, Yael Litvak, J. Sivaraman, Ilan Rosenshine   +18 more
wiley   +1 more source

β, β-Dimethylacrylshikonin Triggers Caspase-Mediated Cell Apoptosis via Heme Oxygenase-1 Upregulation and ERK/p38 Activation in Prostate Cancer. [PDF]

J Cell Mol Med
Weng WC, Hsieh YH, Tang CH, Wang SS, Su CC, Su SC, Yang SF.   +6 more
europepmc   +1 more source

Caenorhabditis elegans and Drosophila melanogaster as Model Organisms in Biofactor Research

BioFactors, Volume 52, Issue 4, July/August 2026.
This review presents Caenorhabditis elegans and Drosophila melanogaster as powerful and ethically sound invertebrate model organisms that can be used to investigate nutritional science questions relating to biofactors. Such nutritional phenotyping studies can bridge the gap between in vitro studies and in vivo research in mammals.
Kai Lüersen, Thomas Roeder, Gerald Rimbach   +2 more
wiley   +1 more source

Modulation of the stress-activated protein kinases Hog1/p38 and a TORC1-dependent kinase by curcumin is stress granule-dependent. [PDF]

J Biol Chem
Zheng L, Cherry ZK, Soltys G, Penner M, Samuell N, Welivita D, Thomas B, Fisher JS, Wang Y.   +8 more
europepmc   +1 more source

Microenvironmental Cues That Regulate Cancer Cell Dormancy in Estrogen‐Receptor Positive and Triple‐Negative Breast Cancer Cell Lines

Cancer Medicine, Volume 15, Issue 7, July 2026.
ABSTRACT The processes regulating cellular dormancy in tumor cells remain inadequately characterized. Further, there are very few models available that can recapitulate a dormancy‐like phenotype in vitro. In this study, we investigated the role of microenvironmental cues in inducing a dormancy‐like phenotype in estrogen receptor‐positive (MCF‐7) and ...
Jinesh Maniar, Pulkit Datt, Prerana P. Dange, Vaishali Kailaje, Mithlesh Lakhera, Mansi Samarth, Tanuja Durve, Anushree Kadam, Khushboo A. Gandhi, Sudeep Gupta   +9 more
wiley   +1 more source

Role of Medullary AKT and p38 MAPK in Regulating Feeding of Broiler Chicks. [PDF]

J Poult Sci
Saneyasu T, Kaihatsu M, Nagata K, Kitayama A, Sakai H, Kamisoyama H, Takegaki J, Honda K.   +7 more
europepmc   +1 more source

Icariin Alleviates Diabetes‐Associated Cognitive Dysfunction Through Modulation of LCN2–MEK/ERK Signaling‐Associated Neuroinflammation

CNS Neuroscience &Therapeutics, Volume 32, Issue 7, July 2026.
Icariin protects against diabetes‐associated cognitive dysfunction by effectively inhibiting the LCN2–MEK/ERK axis and alleviating neuroinflammation. These findings demonstrate that targeting this signaling pathway with icariin may offer a promising strategy for treating cognitive impairment in diabetes. ABSTRACT Objective Diabetes‐associated cognitive
Xinyi Jiao, Yutong Ren, Ziman Yu, Junxiong Zhou, Danyang Wang, Bin Yan, Guoqing Tian   +6 more
wiley   +1 more source