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Mitogen-Activated Protein Kinase p38 Pathway in Venous Ulcer Fibroblasts
Vascular and Endovascular Surgery, 2008Objective: Venous ulcer fibroblasts (w-fb) have attenuated growth compared to normal fibroblasts (n-fb). The MAPKp38 pathway mediates stress-responses in various diseases. We hypothesize that p38 pathway is altered in w-fb. Methods: W-fb were isolated from venous ulcers and n-fb from the ipsilateral thigh.
Joseph D, Raffetto +3 more
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Role of p38 and p44/42 mitogen‐activated protein kinases in microglia
Glia, 2002AbstractAlthough microglial cells are thought to play a beneficial role in the regeneration and plasticity of the central nervous system (CNS), recent studies have indicated that at least some molecules released by microglia may be harmful in acute brain insults and neurodegenerative diseases. Therefore, the pathways mediating the synthesis and release
Milla, Koistinaho, Jari, Koistinaho
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p38 Mitogen-activated protein kinase expression and activation in smooth muscle
American Journal of Physiology-Cell Physiology, 1998There is relatively little known about expression and activation of p38 mitogen-activated protein kinases (MAPKs) through G protein-linked, seven-transmembrane-spanning (STM) receptors in mammalian smooth muscle. To investigate the role of p38 MAPK in smooth muscle, we cloned and sequenced the p38 MAPK expressed in canine smooth muscles.
J C, Hedges +5 more
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Activation of a p38 mitogen-activated protein kinase in human neutrophils by lipopolysaccharide
The Journal of Immunology, 1996Abstract Stimulation of human neutrophils by LPS is central to the pathogenesis of sepsis and the adult respiratory distress syndrome. The intracellular signaling pathway that results in cellular responses following LPS stimulation in neutrophils is unknown.
J A, Nick +4 more
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Intrathymic signals in thymocytes are mediated by p38 mitogen-activated protein kinase
The Journal of Immunology, 1996Abstract Thymocytes develop into mature functional T cells in the inductive environment of the thymus where thymocyte-stromal cell interactions and cytokines provide survival and differentiation signals as cues for thymocyte maturation. Disruption of the thymic microenvironment results in attenuation of T cell maturation, suggesting that
J, Sen +5 more
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Structure-Activity Relationships of p38 Mitogen-Activated Protein Kinase Inhibitors
Mini-Reviews in Medicinal Chemistry, 2005Rheumatoid arthritis and other chronic inflammatory diseases constitute a major therapeutic challenge, usually not sufficiently met by the classical antiinflammatory medications. Recent research efforts provided new insights into the molecular basis of these pathologies and disclosed new opportunities for developing improved drugs directed to the ...
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Assays for JNK and p38 Mitogen-Activated Protein Kinases
2000T, Sudo, M, Karin
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