Results 261 to 270 of about 100,277 (305)

Liver Fibrosis: Molecular Pathogenesis and Therapeutic Interventions

MedComm, Volume 7, Issue 5, May 2026.
We systematically summarized the etiologies, diagnostic approaches, and pathogenic mechanisms of liver fibrosis. Also, the therapeutic interventions for liver fibrosis were systematically classified into two main categories: etiological treatment and mechanism‐based antifibrotic therapies.
Jiaorong Qu, Wenqing Qin, Minghang Dong, Zhi Ma, Si Li, Runping Liu, Ranyun Chen, Changmeng Li, Xiaojiaoyang Li   +8 more
wiley   +1 more source

Albiflorin Relieves Intervertebral Disc Degeneration Through Inhibiting Nucleus Pulposus Cell via the p38 MAPK/NF-κB Pathway. [PDF]

Immun Inflamm Dis
Yang K, Cheng Y, Yang D.
europepmc   +1 more source

Intratumoral Microorganisms in Tumors: Current Understanding and Emerging Therapeutic Strategies

MedComm, Volume 7, Issue 5, May 2026.
Tumors are no longer viewed as sterile but dynamic ecosystems harboring low‐biomass intratumoral microbiota. These microbes, derived from gut, oral cavity, or circulation, shape tumorigenesis and therapy response via core mechanisms: immunomodulation (regulating T cells, macrophages), metabolic reprogramming (SCFAs, indoles, bile acids), chronic ...
Haoling Zhang, Zengkan Du, Ping Lu, Aimin Jiang, Yadong Guo, Yawei Liu, Zhijing Song, Bing Dai, Wangzheqi Zhang   +8 more
wiley   +1 more source

Dexamethasone regulates gene expression in chondrocytes through MKP-1 and downregulates cholesterol hydroxylases CH25H and CYP7B1. [PDF]

Inflamm Res
Lehtola T, Pemmari A, Nummenmaa E, Valjus I, Hämäläinen M, Moilanen T, Vuolteenaho K, Moilanen E.   +7 more
europepmc   +1 more source

MAP3K1: A Multifunctional Kinase at the Crossroads of Cancer Progression and Tumor Suppression. [PDF]

Cells
Umeta LT, Natarajan A.
europepmc   +1 more source

<i>Cornus controversa</i> Leaf and Stem Extract Attenuates LPS-Induced Inflammatory Responses in RAW 264.7 Macrophages via NF-κB/MAPK Inhibition and AMPK Activation. [PDF]

J Microbiol Biotechnol
Choi SY, Shin MS, Son HJ, Kim SB, Song P, Lee KM.   +5 more
europepmc   +1 more source

Fractalkine (Chemokine CX3CL1) Signaling During Placentation and Placental Function. [PDF]

Int J Mol Sci
Szukiewicz D.
europepmc   +1 more source

Multifaceted Anticancer Activity of Flavanone/Chromanone Intermediates for Five-Membered Heterocyclic Derivatives: Targeting Oxidative Stress, Apoptosis, and MAPK Signaling in Colorectal Cancer. [PDF]

Molecules
Hikisz P, Adamus-Grabicka AA, Budzisz E.
europepmc   +1 more source

Lipopolysaccharide induces HIF-1α accumulation via MAPK p38-mediated mRNA stabilization and dexamethasone-sensitive protein stabilization. [PDF]

J Biol Chem
Lockwood C, Daley KK, O'Neil JD, Heighes KJ, Clayton SA, Clark AR.   +5 more
europepmc   +1 more source