Results 21 to 30 of about 177,903 (366)

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source

Isoform-specific and cell/tissue-dependent effects of p38 MAPKs in regulating inflammation and inflammation-associated oncogenesis

Frontiers in Bioscience-Landmark, 2022
p38 MAPK (mitogen-activated protein kinases) family proteins (α, β, γ and δ) are key inflammatory kinases and play an important role in relaying and processing intrinsic and extrinsic signals in response to inflammation, stress, and oncogene to regulate ...
Jian-Zhong Qin, Hong Xin, Xiao-Mei Qi, Guan Chen   +3 more
doaj   +1 more source

The role of p38 MAPK and its substrates in neuronal plasticity and neurodegenerative disease [PDF]

, 2012
A significant amount of evidence suggests that the p38-mitogen-activated protein kinase (MAPK) signalling cascade plays a crucial role in synaptic plasticity and in neurodegenerative diseases.
Corrêa, Sônia A. L., Eales, Katherine L.   +1 more
core   +3 more sources

Dynamic activation and regulation of the mitogen-activated protein kinase p38 [PDF]

Proceedings of the National Academy of Sciences, 2018
Significance The physical basis for the regulation of protein MAP kinases is key to understanding their role in cellular signaling in human biology and disease. However, the biochemical events that lead to MAPK activation are not well understood.
Ganesan Senthil Kumar, Michael W. Clarkson, Micha B. A. Kunze, Daniele Granata, A. Joshua Wand, Kresten Lindorff-Larsen, Rebecca Page, Wolfgang Peti   +7 more
openaire   +4 more sources

Mitogen Activated Protein kinase signal transduction pathways in the prostate

Cell Communication and Signaling, 2004
The biochemistry of the mitogen activated protein kinases ERK, JNK, and p38 have been studied in prostate physiology in an attempt to elucidate novel mechanisms and pathways for the treatment of prostatic disease.
Koul Sweaty, Maroni Paul D, Meacham Randall B, Koul Hari K   +3 more
doaj   +1 more source

The alkaloids of Corydalis hendersonii Hemsl. contribute to the cardioprotective effect against ischemic injury in mice by attenuating cardiomyocyte apoptosis via p38 MAPK signaling pathway

Chinese Medicine, 2023
Highlights The total extract of Corydalis hendersonii Hemsl. (CH) and the rich alkaloids fraction (RAF) of CH showed significant cardioprotective effect on mice following acute myocardial infarction.
Fuxing Ge, Xiaoli Gao, Xiaochun Zhou, Junjun Li, Xiaojing Ma, Meiwen Huang, Sana Wuken, Pengfei Tu, Chao An, Xingyun Chai   +9 more
doaj   +1 more source

Regulation of the JNK pathway by TGF-beta activated kinase 1 in rheumatoid arthritis synoviocytes. [PDF]

, 2007
c-Jun N-terminal kinase (JNK) contributes to metalloproteinase (MMP) gene expression and joint destruction in inflammatory arthritis. It is phosphorylated by at least two upstream kinases, the mitogen-activated protein kinase kinases (MEK) MKK4 and MKK7,
Boyle, David L, Firestein, Gary S, Hammaker, Deepa R, Inoue, Tomoyuki   +3 more
core   +2 more sources

Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine (*)

Journal of Biological Chemistry, 1995
Protein kinases activated by dual phosphorylation on Tyr and Thr (MAP kinases) can be grouped into two major classes: ERK and JNK. The ERK group regulates multiple targets in response to growth factors via a Ras-dependent mechanism.
J. Raingeaud, Shashi Gupta, J. S. Rogers, M. Dickens, Jiahuai Han, R. Ulevitch, R. Davis   +6 more
semanticscholar   +1 more source

p38 Mitogen-Activated Protein Kinase

Journal of the American College of Cardiology, 2006
In this issue of the Journal , Bellahcene et al. ([1][1]) report that tumor necrosis factor-alpha (TNF-α)-induced depression of contractile function of the heart is mediated by a specific intracellular signaling pathway, the p38 mitogen-activated protein kinase (MAPK) pathway.
Risto Kerkelä, Thomas Force
openaire   +2 more sources

Differential effects of ERK and p38 signaling in BMP-2 stimulated hypertrophy of cultured chick sternal chondrocytes [PDF]

, 2005
Background During endochondral bone formation, the hypertrophy of chondrocytes is accompanied by selective expression of several genes including type X collagen and alkaline phosphatase.
Golden, E.B., Grasso-Knight, G., Leboy, P.S., Reilly, G.C.   +3 more
core   +3 more sources