Results 171 to 180 of about 90,894 (265)

Structure‐ and Ligand‐Based Discovery of Novel 3‐Chymotrypsin‐Like Protease Nonpeptidomimetic Hits

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
A multistep virtual screening cascade, integrating shape‐based, ensemble docking, and quantitative structure–activity relationship (QSAR) models, was employed to screen 1.5 million compounds. This funnel identified a novel 3‐chymotrypsin‐like protease (3CLpro) inhibitor, LabMol‐499, which was experimentally validated using a Förster Resonance Energy ...
Sabrina Silva‐Mendonça, Donald Seanego, Christopher Jurisch, Melina Mottin, Flávia Nader Motta, Beatriz S. A. Rodrigues, Gilberto S. M. Junior, Alexandra Maria dos Santos Carvalho, Fábio Muniz de Oliveira, Sunniva Sigurdardóttir, Per Sunnerhagen, Izabela Marques Dourado Bastos, Richard Gessner, Kelly Chibale, Carolina Horta Andrade   +14 more
wiley   +1 more source

Physicochemical Characteristics of Amphipathic Peptides and Their Cytotoxic Effects on Cancer and Normal Cell Lines. [PDF]

Int J Mol Sci
Golonka I, Greber KE, Łapińska Z, Wyrzykowski D, Żamojć K, Sikorska E, Kulbacka J, Sawicki W, Musiał W.   +8 more
europepmc   +1 more source

Proteinvermittelte Kupfer‐Redoxregulation: Rolle von Disulfidbrücken und allosterischer Modulation

Angewandte Chemie, Volume 138, Issue 15, 6 April 2026.
Copper binding triggers structural changes that expose a reactive disulphide bridge, enabling intrinsic Cu(II) reduction in folded proteins. SAXS, XAS, and QM/MM simulations reveal how globular proteins such as HSA and SOD1 employ disulphide‐mediated dynamics to modulate site accessibility and control copper redox chemistry.
Rebecca Sternke‐Hoffmann, Chang Liu, Xue Wang, Hegne Pupart, Xun Sun, Jan Gui‐Hyon Dreiser, Peep Palumaa, Qinghua Liao, Matthias Krack, Jinghui Luo   +9 more
wiley   +1 more source

Protein‐Driven Copper Redox Regulation: Uncovering the Role of Disulphide Bonds and Allosteric Modulation

Angewandte Chemie International Edition, Volume 65, Issue 15, 6 April 2026.
Copper binding triggers structural changes that expose a reactive disulphide bridge, enabling intrinsic Cu(II) reduction in folded proteins. SAXS, XAS, and QM/MM simulations reveal how globular proteins such as HSA and SOD1 employ disulphide‐mediated dynamics to modulate site accessibility and control copper redox chemistry.
Rebecca Sternke‐Hoffmann, Chang Liu, Xue Wang, Hegne Pupart, Xun Sun, Jan Gui‐Hyon Dreiser, Peep Palumaa, Qinghua Liao, Matthias Krack, Jinghui Luo   +9 more
wiley   +1 more source

Repurposing nuclear receptors for ligand-responsive liquid condensate formation and gene regulation. [PDF]

Nat Commun
Rihtar E, Fink T, Ivanovski F, Koplan E, Jerala R.   +4 more
europepmc   +1 more source

Systematic Profiling of Peptide Substrate Specificity in N-Terminal Processing by Methionine Aminopeptidase Using mRNA Display and an Unnatural Methionine Analogue. [PDF]

ACS Chem Biol
Turra RJ, Horiya S, Neralkar M, Bailey JK, Walsh TJ, Horvath V, Krauss IJ.   +6 more
europepmc   +1 more source

Structural Basis and Inhibitor Development of SARS-CoV-2 Papain-like Protease. [PDF]

Molecules
Wang J, Xu Y, Yang Y, Zhang B, Chen S, Li Z, Zhu H, Yang H, Wang H, Zhou Y, Cao P, Zhai B, Gong Y.   +12 more
europepmc   +1 more source

Design and biological evaluation of triagonist GLP-1R/GCGR/GIPR peptides as potential therapeutic agents for diabetes and obesity. [PDF]

RSC Med Chem
Kalinowska I, Gawalska A, Kasprzycka P, Stępniewski M, Rózga P, Pałka A, Shubin A, Bukato K, Gałązka M, Burchard E, Zielińska-Świder P, Jaworski A, Feder M.   +12 more
europepmc   +1 more source

Author Correction: A fluorogenic, peptide-based probe for the detection of Cathepsin D in macrophages. [PDF]

Commun Chem
Rodriguez-Rios M, McHugh BJ, Liang Z, Megia-Fernandez A, Lilienkampf A, Dockrell D, Bradley M.   +6 more
europepmc   +1 more source

GPR56/ADGRG1 regulates development and maintenance of peripheral myelin [PDF]

, 2018
Ackerman, Sarah D, D\u27Rozario, Mitchell, et al,, Gamble, Paul, Harty, Breanne L, MacEwan, Matthew R, Mogha, Amit, Monk, Kelly R, Ray, Wilson Zachary, Sanchez, Nicholas E   +9 more
core   +1 more source