Results 91 to 100 of about 466,841 (162)

Design, synthesis and biological evaluation of novel p53 activators by targeting p53 protein-protein interactions

, 2021
The p53 protein, also known as the “guardian of the genome”, has an important role in the tumor suppression and regulation of cell processes. The majority of human cancers show inactivation of the p53 pathway.
Espadinha, Margarida
core  

Opto-p53: A light-controllable activation of p53 signaling pathway

Cell Structure and Function
p53 protein, a crucial transcription factor in cellular responses to a wide variety of stress, regulates multiple target genes involved in tumor suppression, senescence induction, and metabolic functions.
Tatsuki Tsuruoka, Yuhei Goto, Kazuhiro Aoki   +2 more
doaj   +1 more source

Interaction of p53 with the Δ133p53α and Δ160p53α isoforms regulates p53 conformation and transcriptional activity

Cell Death and Disease
The TP53 gene encodes p53, a transcription factor involved in tumor suppression. However, TP53 also encodes other protein isoforms, some of which can disrupt the tumor suppressor functions of p53 even in the absence of TP53 mutations.
Fanny Tomas, Pierre Roux, Véronique Gire   +2 more
doaj   +1 more source

Strukturelle und funktionelle Untersuchung der p53-Familie, im Besonderen p63 [PDF]

, 2009
The transcription factor p63 is part of the p53 protein family, which consists of three members, p53, p63 and p73. P63 shares structural similarity with all family members, but is associated to different biological functions than p53 or p73. While p53 is
Weber, Tobias Alexander
core  

The Role of Phosphorylation in IR-induced p53 Stabilization and Activation

, 2005
It is well established that tumor suppressor p53 protein is stabilized and activated as a sequence-specific transcriptional factor in response to genotoxic stresses, including ionizing radiation (IR).
Suzuki, Keiji, Yamauchi, Motohiro, Kodama, Seiji, Watanabe, Masami   +3 more
core  

p53-independent activation of the hdm2-P2 promoter through multiple transcription factor response elements results in elevated hdm2 expression in estrogen receptor alpha-positive breast cancer cells

, 2003
The negative-regulatory feedback loop between p53 and hdm2 forms part of a finely balanced regulatory network of proteins that controls cell cycle progression and commitment to apoptosis.
Phelps, Monika, Darley, Matthew, Primrose, John N., Blaydes, Jeremy P.   +3 more
core   +1 more source

Immunohistochemical Study of p53 Overexpression in Radiation-Induced Colon Cancers

, 1998
The expressions of p53 and proliferating cell nuclear antigen (PCNA) were studied immunohistochemically from paraffin sections of 7 cases (9 lesions) of radiation-induced colon cancer and 42 cases of spontaneous colon cancer.
Matsuzaki, Sumihiro, Sekine, Ichiro, Ito, Masahiro, Mokarim, Abul, Hayashi, Nobuyuki, Minami, Kazunori   +5 more
core  

Regulation of cellular factors, p53 and Sp1, on Zta expression upon HDACi-induced EBV reactivation

, 2010
在許多與EB病毒相關的疾病組織中，觀察到p53 過量累積的情形。此外，在這些病患的血清中又可偵測到較高力價的抗EB病毒溶裂期產物之抗體，因此本論文欲探討p53 對於誘導EB病毒再活化進入溶裂期過程中所扮演的角色。 在此研究中，本實驗室先前的研究，已證實在去乙醯酶抑制劑 (HDAC inhibitor)引起鼻咽癌上皮細胞株之EB病毒再活化能力的過程中，p53是重要的因子。進一步研究結果顯示，p53在促使EB病毒再活化之重要樞杻的Zta蛋白質表現過程中扮演重要角色。利用基因減弱試驗 (knockdown)
邱馨誼, Chiu, Hsin-Yi
core  

Transient peak of p53 induction persists at low radiation doses in MCF-7 cells. [PDF]

Mol Biol Rep
Danilova I, Klementová J, Jarošová Š, Kundrát P, Zíková M, Davídková M.   +5 more
europepmc   +1 more source

Pattern-Based P53 Immunohistochemistry Predicts Recurrence in Colorectal Liver Metastases Without Complete Pathologic Response After Neoadjuvant Chemotherapy. [PDF]

Cancer Rep (Hoboken)
Ho PTH, Nguyen DD, Hao VDT, Tran GH, Trung LV, Van Hoang T, Nguyen HB.   +6 more
europepmc   +1 more source